Patents by Inventor Miao Kevin Shi

Miao Kevin Shi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250101521
    Abstract: Provided herein are compositions and methods for detecting exhaled microRNAs for identifying lung diseases such as cancer, asthma, and chronic obstructive pulmonary disease.
    Type: Application
    Filed: December 10, 2024
    Publication date: March 27, 2025
    Inventors: Simon D. Spivack, Miao Kevin Shi, Olivier Loudig, Megan Mitchell
  • Patent number: 8993242
    Abstract: Methods and kits are provided for testing the functional effect of methylating different cytosine residues, for testing patterns of DNA methylation on gene expression, and for site-specific methylation, as well as methylated DNA constructs. Methods are provided that include steps of denaturing a circular double-stranded DNA construct; hybridizing primers to separate strands of the denatured circular DNA construct; contacting the hybridized primers with a DNA polymerase, deoxynucleoside triphosphates, and copies of the primers; contacting nicked copies with a DNA ligase so as to form a copy of the circular DNA construct; contacting the copy of the circular DNA construct with a methyltransferase enzyme; transfecting a cell with C-5 methylated circular DNA construct; and quantifying expression of a gene of interest, thereby determining the effect of C-5 methylating cytosine nucleotide residues of DNA on expression of the gene of interest.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: March 31, 2015
    Assignee: Albert Einstein College of Medicine of Yeshiva University
    Inventors: Weiguo Han, Simon D. Spivack, Miao Kevin Shi
  • Publication number: 20120183961
    Abstract: Methods and kits are provided for testing the functional effect of methylating different cytosine residues or testing patterns of DNA methylation on gene expression. Methods are also provided for site-specific methylation, as well as methylated DNA constructs.
    Type: Application
    Filed: January 13, 2012
    Publication date: July 19, 2012
    Inventors: WEIGUO HAN, Simon D. Spivack, Miao Kevin Shi