Patents by Inventor Miao-Ping Chien

Miao-Ping Chien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SINGLE CELL SELECTION AND ISOLATION
    Publication number: 20220090007
    Abstract: According to one method, a sample with cells contains a phototagging agent. The sample is imaged to identify at least one target cell to be isolated. The identified target cell in the sample is selectively irradiated with photo-activating light for selectively activating the phototagging agent in the target cell to change its fluorescence response. The irradiated target cell is isolated from other cells in the sample based on a difference in its fluorescence response compared to non-activated phototagging agent in the other cells. Further aspects are directed to a corresponding microscope system and chemical compound for use as the phototagging agent.
    Type: Application
    Filed: January 21, 2020
    Publication date: March 24, 2022
    Applicant: ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM
    Inventor: Miao-Ping CHIEN
  • Optical selection of cells
    Patent number: 10077463
    Abstract: Provided herein are photochemical crosslinkers and photocleavable crosslinkers and their uses in methods for cell selection from cell cultures. The photochemical crosslinkers comprise a fluorescent dye and a radical generator. The photocleavable crosslinkers comprise a photocleavable linker linking two electrophilic groups to each other. Also provided are systems for imaging cells comprising a plurality of cells crosslinked to extracellular matrix proteins using a crosslinker as described, an imaging apparatus, an illuminating apparatus, and software for image processing.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: September 18, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Adam E. Cohen, Miao-Ping Chien
  • OPTICAL SELECTION OF CELLS
    Publication number: 20160208308
    Abstract: Provided herein are photochemical crosslinkers and photocleavable crosslinkers and their uses in methods for cell selection from cell cultures. The photochemical crosslinkers comprise a fluorescent dye and a radical generator. The photocleavable crosslinkers comprise a photocleavable linker linking two electrophilic groups to each other. Also provided are systems for imaging cells comprising a plurality of cells crosslinked to extracellular matrix proteins using a crosslinker as described, an imaging apparatus, an illuminating apparatus, and software for image processing.
    Type: Application
    Filed: January 14, 2016
    Publication date: July 21, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Adam E. Cohen, Miao-Ping Chien
  • Nanofibers and morphology shifting micelles
    Patent number: 9040626
    Abstract: The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: May 26, 2015
    Assignee: The Regents of the University of California
    Inventors: Miao-Ping Chien, Nathan C. Gianneschi
  • NANOFIBERS AND MORPHOLOGY SHIFTING MICELLES
    Publication number: 20120149843
    Abstract: The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed.
    Type: Application
    Filed: February 1, 2012
    Publication date: June 14, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Miao-Ping Chien, Nathan C. Gianneschi