Patents by Inventor Miao Wen

Miao Wen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250135025
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: December 30, 2024
    Publication date: May 1, 2025
    Inventors: Amandeep Gakhal, Abigail Yu, Ryan Stafford, Jeffrey Hanson, Alice Yam, Krishna Bajjuri, Andreas Maderna, Christina Abrahams, Xiaofan Li, Gang Yin, Miao Wen, Kristin Bedard, Daniel Calarese, Helena Kiefel
  • Publication number: 20250122306
    Abstract: The present disclosure relates to antibodies and antibody conjugates that selectively bind to tissue factor and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies and antibody conjugates, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: October 11, 2024
    Publication date: April 17, 2025
    Inventors: Grace Jungeun LEE, Amandeep Kaur GAKHAL, Daniel CALARESE, Junhao YANG, Krishna BAJJURI, Xiaofan LI, Sihong ZHOU, Helena KIEFEL, Robert Tian-Xuan YUAN, Andrew James MCGEEHAN, Miao WEN, Gang YIN, Alice yAM
  • Patent number: 12226490
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Grant
    Filed: July 10, 2023
    Date of Patent: February 18, 2025
    Assignee: Sutro Biopharma, Inc.
    Inventors: Amandeep Gakhal, Abigail Yu, Ryan Stafford, Jeffrey Hanson, Alice Yam, Krishna Bajjuri, Andreas Maderna, Cristina Abrahams, Xiaofan Li, Gang Yin, Miao Wen, Kristin Bedard, Daniel Calarese, Helena Kiefel
  • Publication number: 20250018054
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: September 4, 2024
    Publication date: January 16, 2025
    Inventors: Amandeep Gakhal, Abigail Yu, Ryan Stafford, Jeffrey Hanson, Alice Yam, Krishna Bajjuri, Andreas Maderna, Cristina Abrahams, Xiaofan Li, Gang Yin, Miao Wen, Kristin Bedard, Daniel Calarese, Helena Kiefel
  • Patent number: 12144869
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Grant
    Filed: June 30, 2023
    Date of Patent: November 19, 2024
    Assignee: SUTRO BIOPHARMA, INC.
    Inventors: Amandeep Gakhal, Abigail Yu, Ryan Stafford, Jeffrey Hanson, Alice Yam, Krishna Bajjuri, Andreas Maderna, Cristina Abrahams, Xiaofan Li, Gang Yin, Miao Wen, Kristin Bedard, Daniel Calarese, Helena Kiefel
  • Publication number: 20240058467
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: July 10, 2023
    Publication date: February 22, 2024
    Inventors: AMANDEEP GAKHAL, ABIGAIL YU, RYAN STAFFORD, JEFFREY HANSON, ALICE YAM, KRISHNA BAJJURI, ANDREAS MADERNA, CRISTINA ABRAHAMS, XIAOFAN LI, GANG YIN, MIAO WEN, KRISTIN BEDARD, DANIEL CALARESE, HELENA KIEFEL
  • Publication number: 20240058465
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: June 30, 2023
    Publication date: February 22, 2024
    Inventors: Amandeep Gakhal, Abigail Yu, Ryan Stafford, Jeffrey Hanson, Alice Yam, Krishna Bajjuri, Andreas Maderna, Cristina Abrahams, Xiaofan Li, Gang Yin, Miao Wen, Kristin Bedard, Daniel Calarese, Helena Kiefel
  • Patent number: 9887102
    Abstract: A multi-chip package structure is provided, including a substrate having a grounding structure; two semiconductor elements disposed on and electrically connected to the substrate; an encapsulant formed on the substrate and encapsulating semiconductor elements, wherein the encapsulant has a plurality of round holes formed between the semiconductor elements; and an electromagnetic shielding structure formed in each of the round holes and connected to the grounding structure to achieve electromagnetic shielding effects. A method for forming the multi-chip package is also provided.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: February 6, 2018
    Assignee: Siliconware Precision Industries Co., Ltd.
    Inventors: Tai-Tsung Hsu, Cheng-Yu Chiang, Miao-Wen Chen, Wen-Jung Chiang, Hsin-Hung Lee
  • Publication number: 20160181126
    Abstract: A multi-chip package structure is provided, including a substrate having a grounding structure; two semiconductor elements disposed on and electrically connected to the substrate; an encapsulant formed on the substrate and encapsulating semiconductor elements, wherein the encapsulant has a plurality of round holes formed between the semiconductor elements; and an electromagnetic shielding structure formed in each of the round holes and connected to the grounding structure to achieve electromagnetic shielding effects. A method for forming the multi-chip package is also provided.
    Type: Application
    Filed: February 26, 2016
    Publication date: June 23, 2016
    Inventors: Tai-Tsung Hsu, Cheng-Yu Chiang, Miao-Wen Chen, Wen-Jung Chiang, Hsin-Hung Lee
  • Patent number: 9305885
    Abstract: A multi-chip package structure is provided, including a substrate having a grounding structure; two semiconductor elements disposed on and electrically connected to the substrate; an encapsulant formed on the substrate and encapsulating semiconductor elements, wherein the encapsulant has a plurality of round holes formed between the semiconductor elements; and an electromagnetic shielding structure formed in each of the round holes and connected to the grounding structure to achieve electromagnetic shielding effects. A method for forming the multi-chip package is also provided.
    Type: Grant
    Filed: August 6, 2013
    Date of Patent: April 5, 2016
    Assignee: Siliconware Precision Industries Co., Ltd.
    Inventors: Tai-Tsung Hsu, Cheng-Yu Chiang, Miao-Wen Chen, Wen-Jung Chiang, Hsin-Hung Lee
  • Publication number: 20140231972
    Abstract: A multi-chip package structure is provided, including a substrate having a grounding structure; two semiconductor elements disposed on and electrically connected to the substrate; an encapsulant formed on the substrate and encapsulating semiconductor elements, wherein the encapsulant has a plurality of round holes formed between the semiconductor elements; and an electromagnetic shielding structure formed in each of the round holes and connected to the grounding structure to achieve electromagnetic shielding effects. A method for forming the multi-chip package is also provided.
    Type: Application
    Filed: August 6, 2013
    Publication date: August 21, 2014
    Applicant: Siliconware Precision Industries Co., Ltd.
    Inventors: Tai-Tsung Hsu, Cheng-Yu Chiang, Miao-Wen Chen, Wen-Jung Chiang, Hsin-Hung Lee
  • Publication number: 20140004597
    Abstract: The present disclosure provides optimized recombinant cells for the production of n-butanol. Methods for the use of these cells are also provided. Specifically, the utility of acylating aldehyde dehydrogenases and pyruvate:flavodoxin/ferredoxin-oxidoreductase for the improvement of n-butanol yields from recombinant cells is disclosed.
    Type: Application
    Filed: December 7, 2012
    Publication date: January 2, 2014
    Applicant: The Regents of the University of California
    Inventors: Michelle C.Y. CHANG, Brooks Bond-Watts, Miao Wen, Jeffrey A. Hanson