Abstract: A compound represented by formula (I) or a tautomer, an optical isomer, a nitrogen oxide, a solvate, a pharmaceutically acceptable salt or prodrug thereof are useful for treating or relieving an HIF-related and/or EPO-related disease or condition in patient. The preparation method for the compound, and use of a drug composition containing the compound and the compound or the drug composition in preparation of a drug are also provided.

Abstract: The invention discloses a serial high-temperature gas-cooled reactor nuclear energy system and an operating method thereof. The serial high-temperature gas-cooled reactor nuclear energy system includes a plurality of high-temperature gas-cooled reactors and a serial gas-cooled reactor. The high-temperature gas-cooled reactor includes a first reactor pressure vessel comprising a first reaction chamber for accommodating the first fuel element; a second reactor pressure vessel comprising a second reaction chamber interconnected with the first reaction chamber, allowing the first spent fuel in the first reaction chamber to enter the second reaction chamber.

Abstract: A compound represented by formula (I) or a tautomer, an optical isomer, a nitrogen oxide, a solvate, a pharmaceutically acceptable salt or prodrug thereof are useful for treating or relieving an HIF-related and/or EPO-related disease or condition in patient. The preparation method for the compound, and use of a drug composition containing the compound and the compound or the drug composition in preparation of a drug are also provided.