Patents by Inventor Micael J. Hardy

Micael J. Hardy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mito-honokiol compounds and methods of synthesis and use thereof
    Patent number: 11897910
    Abstract: The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: February 13, 2024
    Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael J. Hardy, Olivier Ouari, Ming You
  • Mito-lonidamine, compositions and methods of use
    Patent number: 11352382
    Abstract: The present invention relates to mito-lonidamine compounds, compositions and methods of use in the treatment of cancer.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: June 7, 2022
    Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Micael J. Hardy, Olivier Ouari
  • Modified mito-metformin compounds and methods of synthesis and use thereof
    Patent number: 11274114
    Abstract: The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: March 15, 2022
    Assignees: The Medical College of Wisconsin, Inc., AIX-Marseille Universite, Iowa State University Research Foundation, Inc.
    Inventors: Balaraman Kalyanaramn, Micael J. Hardy, Marcos Lopez, Olivier Ouari, Jacek Michal Zielonka
  • Mito-Honokiol Compounds and Methods of Synthesis and Use Thereof
    Publication number: 20210070787
    Abstract: The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.
    Type: Application
    Filed: November 16, 2020
    Publication date: March 11, 2021
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Gang Cheng, Micael J. Hardy, Olivier Ouari, Ming You
  • Mito-honokiol compounds and methods of synthesis and use thereof
    Patent number: 10836782
    Abstract: The present invention provides mito-honokiol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol compounds in the treatment of cancer.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: November 17, 2020
    Assignees: The Medical College of Wisconsin, Inc., Aix-Marseille Universite
    Inventors: Balaraman Kalyanaraman, Jacek Michal Zielonka, Micael J. Hardy, Oliver Ouari, Ming You
  • MITO-HONOKIOL COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF
    Publication number: 20180134737
    Abstract: The present invention provides mito-honokiol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol compounds in the treatment of cancer.
    Type: Application
    Filed: June 10, 2016
    Publication date: May 17, 2018
    Inventors: Balaraman KALYANARAMAN, Jacek Michal Zlelonka, Micael J. Hardy, Oliver Ouari, Ming You
  • MODIFIED MITO-METFORMIN COMPOUNDS AND METHODS OF SYNTHESIS AND USE THEREOF
    Publication number: 20170275313
    Abstract: The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.
    Type: Application
    Filed: August 13, 2015
    Publication date: September 28, 2017
    Inventors: Balaraman Kalyanaramn, Micael J. Hardy, Marcos Lopez, Olivier Ouari, Jacek Michal Zielonka
  • In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging
    Patent number: 8388936
    Abstract: A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: March 5, 2013
    Assignee: MCW Research Foundation, Inc.
    Inventors: Balaraman Kalyanaraman, Joy Joseph, Kathleen Marie Schmainda, Douglas Edward Prah, Marcos Lopez, Micael J. Hardy
  • In Vivo Mitochondrial Labeling Using Positively-Charged Nitroxide Enhanced and Gadolinium Chelate Enhanced Magnetic Resonance Imaging
    Publication number: 20090214437
    Abstract: A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.
    Type: Application
    Filed: February 23, 2009
    Publication date: August 27, 2009
    Applicant: Medical College of Wisconsin Research Foundation
    Inventors: Balaraman Kalyanaraman, Joy Joseph, Kathleen Marie Schmainda, Douglas Edward Prah, Marcos Lopez, Micael J. Hardy