Patents by Inventor Mice Kovacevic

Mice Kovacevic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amides of 4-oxo-azetidine-2-sulfonic acids and salts thereof, processes for their preparation and their use
    Patent number: 5466686
    Abstract: The invention relates to the novel 4-oxo-azetidine-2-sulfonic acid amides and their salts of the formula I ##STR1## wherein the radicals have the meanings: R.sup.1 =hydrogen, halogen;R.sup.2 =hydrogen, halogen, NH.sub.2, C.sub.6 H.sub.5 CH.sub.2 CONH, C.sub.6 H.sub.5 OCH.sub.2 CONH, phthalimido, o-MeNHCOC.sub.6 H.sub.4 CONH, isoxazolylcarbonylamino;R.sup.3 =hydrogen, Me.sub.2 C.dbd.C--COOMe, H.sub.2 C.dbd.C(Me)--CH--COOMe, Me.sub.2 C.dbd.C--COOCH.sub.2 C.sub.6 H.sub.5, H.sub.2 C.dbd.C(Me)CH--COOCH.sub.2 C.sub.6 H.sub.4 NO.sub.2 -p, Me.sub.2 C.dbd.C--COOCH.sub.2 C.sub.6 H.sub.4 NO.sub.2 -p, Me.sub.2 C.dbd.C--COOCH.sub.2 C.sub.6 H.sub.4 Me-m, H.sub.2 C.dbd.C(Me)--CH--COOCH.sub.2 C.sub.6 H.sub.4 Me-m, Me.sub.2 C.dbd.C--COOH;R.sup.4 =hydrogen or sodium andR.sup.5 =hydrogen, alkyl, benzyl or heterocycle, i.e. isoxazole or pyrazole etc.
    Type: Grant
    Filed: September 3, 1993
    Date of Patent: November 14, 1995
    Assignee: PLIVA and PLIVA Handels GmbH
    Inventors: Mice Kovacevic, Jure J. Herak, Zora Mandic, Irena Lukic, Mirjana Tomic, Zinka Brkic
  • 5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo analogs of .beta.-lactam, processes for the preparation thereof and the use thereof
    Patent number: 5446038
    Abstract: 5-Thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo analogs of .beta.-lactam, processes for the preparation thereof and the use thereofDisclosed are novel 5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo .beta.-lactam analogs of the general formula I ##STR1## wherein R.sup.1 is hydrogen or halo;R.sup.2 is hydrogen, halo, amino, PhCH.sub.2 CONH, PhOCH.sub.2 CONH, phthalimido, o-MeNHCO-C.sub.6 H.sub.4 -CONH, isoxazolylcarboxamido;R.sup.3 is hydrogen, alkyl, benzyl, heterocycle, e.g. isoxazole, pyrazole etc., andn may be 1 or 2.They may be used as intermediates in preparing novel .beta.-lactam analogs or as active substances in formulations for antimicrobial therapy.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: August 29, 1995
    Assignee: PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko
    Inventors: Mice Kovacevic, Jure J. Herak, Zora Mandiec, Irena Lukic, Mirjana Tomic, Zinka Brkic
  • 4-oxo-azetidine-2-sulfonic acids and their salts, processes for the preparation thereof and their use
    Patent number: 5250525
    Abstract: The invention relates to novel 4-oxo-azetidine-2-sulfonic acids and their salts or the formula I ##STR1## wherein: R.sup.1 =hydrogen, halogen, phenylacetamido;R.sup.2 =hydrogen, halogen, phenylacetamido, phenoxyacetamido, phthalimido, 5-methyl-3-o-chlorophenyl-isoxazole-4-carboxamido;R.sup.3 =hydrogen, alkali metal, alkaline earth metal, quaternary ammonium group;R.sup.4 =hydrogen, SO.sub.2 O.sup.-+ NBu.sub.4 -n, (CH.sub.3).sub.2 C.dbd.C--COOCH.sub.3, (CH.sub.3).sub.2 C.dbd.C--COOCH.sub.2 -Ph, (CH.sub.3).sub.2 C.dbd.C--COOCH.sub.2 --C.sub.6 H.sub.4 --NO.sub.2 -p, (CH.sub.3).sub.2 C.dbd.C--COOCH.sub.2 --C.sub.6 H.sub.4 --CH.sub.3 -m.The products (I) may be used as intermediates in the synthesis of beta-lactamic antibiotics or as components in antimicrobial preparations.
    Type: Grant
    Filed: February 11, 1992
    Date of Patent: October 5, 1993
    Assignee: Pliva Handels GmbH
    Inventors: Mice Kovacevic, Zorica Mandic, Mirjana Tomic, Zinka Brkic, Jure J. Herak, Irena Lukic