Patents by Inventor Mich B. Hein
Mich B. Hein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8729341Abstract: The invention is generally related to methods of generating plants transformed with novel autonomous mini-chromosomes. Mini-chromosomes with novel compositions and structures are used to transform plants cells which are in turn used to generate the plant. Methods for generating the plant include methods for delivering the mini-chromosome into plant cell to transform the cell, methods for selecting the transformed cell, and methods for isolating plants transformed with the mini-chromosome. Plants generated in the present invention contain novel genes introduced into their genome by integration into existing chromosomes.Type: GrantFiled: February 23, 2005Date of Patent: May 20, 2014Assignees: University of Chicago, Chromatin Inc.Inventors: Helge Zieler, James Jin, Jennifer M. Mach, Gary W. Rudgers, Daphne Preuss, Mich B. Hein, Gregory P. Copenhaver, Kevin Keith
-
Patent number: 8350120Abstract: The invention is generally related to methods of generating plants transformed with novel autonomous mini-chromosomes. Mini-chromosomes with novel compositions and structures are used to transform plants cells which are in turn used to generate the plant. Methods for generating the plant include methods for delivering the mini-chromosome into plant cell to transform the cell, methods for selecting the transformed cell, and methods for isolating plants transformed with the mini-chromosome. Plants generated in the present invention contain novel genes introduced into their genome by integration into existing chromosomes.Type: GrantFiled: March 5, 2010Date of Patent: January 8, 2013Assignees: The Univesity of Chicago, Chromatin, Inc.Inventors: Helge Zieler, James Jin, Jennifer M Mach, Gary W Rudgers, Daphne Preuss, Mich B Hein, Gregory P Copenhaver, Kevin Keith
-
Patent number: 8106169Abstract: This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant calli; transformed plant tissues (e.g., leaves, seeds, tubers, etc.); transformed whole plants used to produce such immunoglobulins; methods of producing the immunoglobulins; the immunoglobulins produced by the disclosed methods; and the use of such immunoglobulins.Type: GrantFiled: November 28, 2003Date of Patent: January 31, 2012Assignee: Phyton Holdings, LLCInventors: Kristen Briggs, Todd Glancy, Mich B. Hein, Andrew C. Hiatt, Anton S. Karnoup, W. H. Kerr Anderson, Dayakar Pareddy, Joseph Petolino, Beth Rubin-Wilson, Doug Taylor, Jean L. Roberts
-
Publication number: 20100235948Abstract: The invention is generally related to methods of generating plants transformed with novel autonomous mini-chromosomes. Mini-chromosomes with novel compositions and structures are used to transform plants cells which are in turn used to generate the plant. Methods for generating the plant include methods for delivering the mini-chromosome into plant cell to transform the cell, methods for selecting the transformed cell, and methods for isolating plants transformed with the mini-chromosome. Plants generated in the present invention contain novel genes introduced into their genome by integration into existing chromosomes.Type: ApplicationFiled: March 5, 2010Publication date: September 16, 2010Applicant: CHROMATIN, INC.Inventors: Helge ZIELER, James JIN, Jennifer M. MACH, Gary W. RUDGERS, Daphne PREUSS, Mich B. HEIN, Gregory P. COPENHAVER, Kevin KEITH
-
Patent number: 7311912Abstract: Targeting molecules for use in delivering biological agents to epithelial tissue are disclosed. Upon delivery, the biological agent(s) may remain within an epithelial cell or may undergo transepithelial transport via transcytosis. The targeting molecules may be used, for example, for the delivery of therapeutic agents.Type: GrantFiled: January 9, 1998Date of Patent: December 25, 2007Assignee: Plantbodies CorporationInventors: Mich B. Hein, Andrew C. Hiatt, John H. Fitchen
-
Patent number: 7282625Abstract: The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.Type: GrantFiled: February 27, 2003Date of Patent: October 16, 2007Assignee: The Scripps Research InstituteInventors: Mich B. Hein, Andrew C. Hiatt
-
Patent number: 7101688Abstract: The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.Type: GrantFiled: February 25, 2003Date of Patent: September 5, 2006Assignee: The Scripps Research InstituteInventors: Mich B. Hein, Andrew C. Hiatt
-
Patent number: 7037722Abstract: The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.Type: GrantFiled: February 24, 2000Date of Patent: May 2, 2006Assignee: The Scripps Research InstituteInventors: Mich B. Hein, Andrew Hiatt
-
Patent number: 7022309Abstract: Targeting molecules are provided for use in delivering imaging agents to epithelial tissue. The targeting molecule comprises a polypeptide that forms a closed covalent loop, contains at least three peptide domains having ?-sheet character, each of the domains being separated by domains lacking ?-sheet character. The targeting molecule specifically binds to a basolateral factor attached to a basolateral domain of an epithelial cell surface causing internalization of a linked imaging agent into the cells. The polypeptide or imaging agent may be linked to a peptide amino acid sequence that directs delivery of the imaging agent to a carcinoma cell, a nucleus, or an endoplasmic reticulum.Type: GrantFiled: February 5, 2002Date of Patent: April 4, 2006Assignee: Biolex Newco I, Inc.Inventors: Andrew C. Hiatt, Mich B. Hein, John H. Fitchen
-
Patent number: 7005560Abstract: The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.Type: GrantFiled: November 25, 1998Date of Patent: February 28, 2006Assignee: The Scripps Research InstituteInventors: Mich B. Hein, Andrew Hiatt
-
Patent number: 6995014Abstract: The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.Type: GrantFiled: February 24, 2000Date of Patent: February 7, 2006Assignee: The Scripps Research InstituteInventors: Mich B. Hein, Andrew Hiatt, Julian K-C Ma
-
Patent number: 6852319Abstract: The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.Type: GrantFiled: January 25, 2000Date of Patent: February 8, 2005Assignee: The Scripps Research InstitueInventors: Mich B. Hein, Andrew Hiatt, Julian K-C Ma
-
Patent number: 6696620Abstract: Arrays of immunoglobulin binding proteins in plants or plant cells are provided. Such arrays comprise plants or plant cells transformed with polynucleotides encoding multiple different immunoglobulin binding proteins, or polypeptide components thereof. Methods are further provided for genetic segregation of the transformation events such that each transformant in an array is capable of producing progeny capable of expressing one or more immunoglobulin binding proteins, including multi-subunit proteins.Type: GrantFiled: May 2, 2000Date of Patent: February 24, 2004Assignee: Epicyte Pharmaceutical, Inc.Inventors: Andrew C. Hiatt, Mich B. Hein
-
Publication number: 20030224443Abstract: Targeting molecules are provided for use in delivering imaging agents to epithelial tissue. The targeting molecule comprises a polypeptide that forms a closed covalent loop, contains at least three peptide domains having &bgr;-sheet character, each of the domains being separated by domains lacking &bgr;-sheet character. The targeting molecule specifically binds to a basolateral factor attached to a basolateral domain of an epithelial cell surface causing internalization of a linked imaging agent into the cells. The polypeptide or imaging agent may be linked to a peptide amino acid sequence that directs delivery of the imaging agent to a carcinoma cell, a nucleus, or an endoplasmic reticulum.Type: ApplicationFiled: February 5, 2002Publication date: December 4, 2003Applicant: Epicyte Pharmaceutical, Inc.Inventors: Andrew C. Hiatt, Mich B. Hein, John H. Fitchen
-
Publication number: 20030172407Abstract: The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.Type: ApplicationFiled: February 27, 2003Publication date: September 11, 2003Applicant: The Scripps Research InstituteInventors: Mich B. Hein, Andrew Hiatt
-
Publication number: 20030167534Abstract: The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.Type: ApplicationFiled: February 25, 2003Publication date: September 4, 2003Applicant: The Scripps Research InstituteInventors: Mich B. Hein, Andrew Hiatt
-
Publication number: 20030079253Abstract: Arrays of immunoglobulin binding proteins in plants or plant cells are provided. Such arrays comprise plants or plant cells transformed with polynucleotides encoding multiple different immunoglobulin binding proteins, or polypeptide components thereof. Methods are further provided for genetic segregation of the transformation events such that each transformant in an array is capable of producing progeny capable of expressing one or more immunoglobulin binding proteins, including multi-subunit proteins.Type: ApplicationFiled: May 2, 2000Publication date: April 24, 2003Inventors: Andrew C. Hiatt, Mich B. Hein
-
Publication number: 20030028913Abstract: The present invention relates to expression and assembly of foreign multimeric proteins —e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.Type: ApplicationFiled: January 25, 2000Publication date: February 6, 2003Inventors: Mich B. Hein, Andrew Hiatt, Julian K-C Ma
-
Publication number: 20020159958Abstract: The immunoglobulins of the present invention are useful therapeutic immunoglobulins against mucosal pathogens such as S. mutans. The immunoglobulins contain a protection protein that protects the immunoglobulins in the mucosal environment.Type: ApplicationFiled: October 16, 2001Publication date: October 31, 2002Applicant: The Scripps Research InstituteInventors: Andrew C. Hiatt, Mich B. Hein
-
Patent number: 6440419Abstract: Targeting molecules for use in delivering biological agents to non-polarized epithelial cells are disclosed. Upon delivery, the biological agent(s) are lethal to the epithelial cell. The targeting molecules may be used, for example, for the eradication of metastatic epithelial cells.Type: GrantFiled: October 20, 1998Date of Patent: August 27, 2002Assignee: Epicyte Pharmaceutical, Inc.Inventors: Mich B. Hein, Andrew C. Hiatt, John H. Fitchen