Patents by Inventor Michèle Launay

Michèle Launay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolizine compounds useful as anti-inflammatory agents
    Patent number: 7375237
    Abstract: Pyrrolizine compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective in treating inflammatory or immune diseases, where A is a four- to seven-membered saturated ring, K is O or S, and R1, R2, R3 n, and M are defined in the specification.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: May 20, 2008
    Assignees: Bristol-Myers Squibb Company, Cerep SA
    Inventors: T. G. Murali Dhar, Dharmpal S. Dodd, Dominique Potin, Michele Launay
  • Aryl carbamate derivatives, preparation and use thereof
    Patent number: 7238693
    Abstract: The present invention relates to novel compounds, the preparation and use, particularly therapeutic, thereof. More specifically, it relates to compounds derived from aryl carbamates, the preparation and use thereof, particularly in the field of human and animal health. The compounds according to the invention are preferably 5-HT4 serotoninergic receptor ligands and can therefore be used in the therapeutic or prophylactic treatment of any disorder involving a 5-HT4 receptor. The invention also relates to pharmaceutical compositions comprising such compounds, the preparation and use thereof and treatment methods using said compounds.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: July 3, 2007
    Assignees: Cerep, Centre National de la Recherche Scientifique, Institut National de la Santa et de la Recherche Medicale (inserm)
    Inventors: Eric Nicolai, Sophie Curtet, James Sicsic, Frank Lezoualc'h, Rodolphe Fischmeister, Michel Langlois, Magali Maillet, Michèle Launay
  • Spiro-cyclic compounds useful as anti-inflammatory agents
    Patent number: 7199125
    Abstract: The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K and L are independently, O or S; Q is —C(?O)— or optionally substituted C1-6alkylene; Ar is optionally-substituted aryl or heteroaryl; J1, J2, J3 and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; R1 is N or C(R9); and R2, and R3, are as defined in the specification.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: April 3, 2007
    Assignees: Bristol-Myers Squibb Company, Cerep SA
    Inventors: T. G. Murali Dhar, Edwin Iwanowicz, Michele Launay, Dominique Potin, Magali Jeannine Blandine Maillet, Eric Nicolai
  • Pyridyl-substituted spiro-hydantoin compounds and use thereof
    Patent number: 7186727
    Abstract: A class of substituted spiro-hydantoin compounds (II) having the formula: its pharmaceutically acceptable salts, enantiomers, solvates, or prodrugs thereof, wherein R16 is a substituted pyridinyl group, as defined herein, is provided. Pharmaceutical compositions and methods of treating anti-inflammatory and/or immune diseases with the pyridyl-substituted spiro-hydantoin compounds are also objectives of this invention.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: March 6, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: T. G. Murali Dhar, Michele Launay, Dominique Potin, Scott Hunter Watterson, Zili Xiao
  • Spiro-hydantoin compounds useful as anti-inflammatory agents
    Patent number: 7078420
    Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR4b; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R2, R4a, R4b, and R4c are as defined in the specification.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: July 18, 2006
    Assignees: Bristol-Myers Squibb Company, Cerep SA
    Inventors: T. G. Murali Dhar, Dominique Potin, Magali Jeannine Blandine Maillet, Michele Launay, Eric Antoine Nicolai, Edwin J. Iwanowicz
  • Pyridyl-substituted spiro-hydantoin compounds and use thereof
    Publication number: 20060148836
    Abstract: A class of substituted spiro-hydantoin compounds (II) having the formula: its pharmaceutically acceptable salts, enantiomers, solvates, or prodrugs thereof, wherein R16 is a substituted pyridinyl group, as defined herein, is provided. Pharmaceutical compositions and methods of treating anti-inflammatory and/or immune diseases with the pyridyl-substituted spiro-hydantoin compounds are also objectives of this invention.
    Type: Application
    Filed: December 13, 2005
    Publication date: July 6, 2006
    Inventors: T.G. Dhar, Michele Launay, Dominique Potin, Scott Watterson, Zili Xiao
  • Pyrrolizine compounds useful as anti-inflammatory agents
    Publication number: 20060052434
    Abstract: Pyrrolizine compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective in treating inflammatory or immune diseases, where A is a four- to seven-membered saturated ring, K is O or S, and R1, R2, R3 n, and M are defined in the specification.
    Type: Application
    Filed: August 18, 2005
    Publication date: March 9, 2006
    Inventors: T. G. Dhar, Dharmpal Dodd, Dominique Potin, Michele Launay
  • Spiro-hydantoin compounds useful as anti-inflammatory agents
    Patent number: 6977267
    Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR4b; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R2,R4a, R4b, and R4c are as defined in the specification.
    Type: Grant
    Filed: October 1, 2002
    Date of Patent: December 20, 2005
    Assignees: Bristol-Myers Squibb Company, CEREP SA
    Inventors: T. G. Murali Dhar, Dominique Potin, Magali Jeannine Blandine Maillet, Michele Launay, Eric Antoine Nicolai, Edwin J. Iwanowicz
  • Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
    Patent number: 6974815
    Abstract: The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K is O or S; Q is —C(?O)— or optionally substituted C1-4alkylene; Ar is optionally-substituted aryl or heteroaryl; J1, J2, J3, and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; Z is N or C(R9); and R1, R2, R3 and R9 are as defined in the specification.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: December 13, 2005
    Assignees: Bristol-Myers Squibb Company, Cerep SA
    Inventors: T G. Murali Dhar, Dominique Potin, Magali Jeannine Blandine Maillet, Michele Launay, Eric Antoine Nicolai, Edwin J. Iwanowicz
  • Spiro-cyclic compounds useful as anti-inflammatory agents
    Publication number: 20050119279
    Abstract: The present invention is directed to compounds having the formula (I): useful in treating inflammatory and immune diseases, in which K and L are independently, O or S; Q is —C(?O)— or optionally substituted C1-6alkylene; Ar is optionally-substituted aryl or heteroaryl; J1, J2, J3 and Y are selected so that ring A is a five-to-six membered optionally-substituted cycloalkenyl or heterocyclo ring having 0 to 2 nitrogen heteroatoms; R1 is N or C(R9); and R2, and R3, are as defined in the specification.
    Type: Application
    Filed: October 1, 2004
    Publication date: June 2, 2005
    Inventors: T. G. Dhar, Edwin Iwanowicz, Michele Launay, Dominique Potin, Magali Blandine Maillet, Eric Nicolai
  • Spiro-hydantoin compounds useful as anti-inflammatory agents
    Publication number: 20050004153
    Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, are useful as inhibitors of LFA-1/ICAM and as anti-inflammatory agents, wherein L and K are O or S; Z is N or CR4b; Ar is an optionally-substituted aryl or heteroaryl; G is a linker attached to T or M or is absent; J, M and T are selected to define a three to six membered saturated or partially unsaturated non-aromatic ring; and R2, R4a, R4b, and R4c are as defined in the specification.
    Type: Application
    Filed: June 16, 2004
    Publication date: January 6, 2005
    Inventors: T.G. Dhar, Dominique Potin, Magali Blandine Maillet, Michele Launay, Eric Nicolai, Edwin Iwanowicz
  • Spiro-hydantoin compounds useful as anti-inflammatory agents
    Publication number: 20040259897
    Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, 1
    Type: Application
    Filed: June 16, 2004
    Publication date: December 23, 2004
    Inventors: T.G. Murali Dhar, Dominique Potin, Magali Jeannine Blandine Maillet, Michele Launay, Eric Antoine Nicolai, Edwin J. Iwanowicz
  • Spiro-hydantoin compounds useful as anti-inflammatory agents
    Publication number: 20040248920
    Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, 1
    Type: Application
    Filed: May 24, 2004
    Publication date: December 9, 2004
    Inventors: T.G. Murali Dhar, Dominique Potin, Magali Jeannine Blandine Maillet, Michele Launay, Eric Antoine Nicolai, Edwin J. Iwanowicz
  • Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
    Publication number: 20040116467
    Abstract: The present invention is directed to compounds having the formula (I): 1
    Type: Application
    Filed: October 9, 2003
    Publication date: June 17, 2004
    Inventors: T.G. Murali Dhar, Dominique Potin, Magali Jeannine Blandine Maillet, Michele Launay, Eric Antoine Nicolai, Edwin J. Iwanowicz
  • Aryl carbamate derivatives, preperation and use thereof
    Publication number: 20040058933
    Abstract: The present invention relates to novel compounds, the preparation and use, particularly therapeutic, thereof. More specifically, it relates to compounds derived from aryl carbamates, the preparation and use thereof, particularly in the field of human and animal health. The compounds according to the invention are preferably 5-HT4 serotoninergic receptor ligands and can therefore be used in the therapeutic or prophylactic treatment of any disorder involving a 5-HT4 receptor. The invention also relates to pharmaceutical compositions comprising such compounds, the preparation and use thereof and treatment methods using said compounds.
    Type: Application
    Filed: August 13, 2003
    Publication date: March 25, 2004
    Inventors: Eric Nicolai, Sophie Curtet, James Sicsic, Frank Lezoualc'h, Rodolphe Fischemeister, Michel Langlois, Magali Maillet, Michele Launay
  • Hydantoin compounds useful as anti-inflammatory agents
    Patent number: 6710064
    Abstract: Compounds having the formula (I): and pharmaceutically-acceptable salts thereof, are useful for treating inflammatory or immune diseases, in which A is a four to seven membered heterocyclic or carbocyclic saturated ring; L and K are O or S; M is N or CH; Y is N or CH; Z is hydrogen, alkyl or substituted alkyl; and R1-R4 are as defined in the specification.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: March 23, 2004
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Michele Launay, Dominique Potin, Magali Jeannine Blandine Maillet, Eric Antoine Nicolai, T. G. Murali Dhar, Edwin J. Iwanowicz
  • Spiro-hydantoin compounds useful as anti-inflammatory agents
    Publication number: 20040009998
    Abstract: Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, enantiomers, and diastereomers, and prodrugs thereof, 1
    Type: Application
    Filed: October 1, 2002
    Publication date: January 15, 2004
    Inventors: T. G. Murali Dhar, Dominique Potin, Magali Jeannine Blandine Maillet, Michele Launay, Eric Antoine Nicolai, Edwin J. Iwanowicz
  • Urazole compounds useful as anti-inflammatory agents
    Patent number: 6673825
    Abstract: Urazole compounds having the formula (I), or pharmaceutically-acceptable salts thereof, are effective as anti-inflammatory or immunosuppressive agents, wherein L and K are O or S; Q is a linker such as —O—, —S—, C(═O), and so forth, R1 is an aryl or heteroaryl group, and R3, R4a, R4c, Z, r, s and t are as defined in the specification.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: January 6, 2004
    Assignees: Bristol-Myers Squibb Co., Cerep SA
    Inventors: Michele Launay, Dominique Potin, Magali Jeannine Blandine Maillet, Eric Antoine Nicolai, Edwin J. Iwanowicz, T. G. Murali Dhar
  • Urazole compounds useful as anti-inflammatory agents
    Publication number: 20030013745
    Abstract: Urazole compounds having the formula (I), 1
    Type: Application
    Filed: May 21, 2002
    Publication date: January 16, 2003
    Inventors: Michele Launay, Dominique Potin, Magali Jeannine Blandine Maillet, Eric Antoine Nicolai, Edwin J. Iwanowicz, T. G. Murali Dhar
  • Hydantoin compounds useful as anti-inflammatory agents
    Publication number: 20020143035
    Abstract: Compounds having the formula (I): 1
    Type: Application
    Filed: November 30, 2001
    Publication date: October 3, 2002
    Inventors: Michele Launay, Dominique Potin, Magali Jeannine Blandine Maillet, Eric Antoine Nicolai, T.G. Murali Dhar, Edwin J. Iwanowicz