Abstract: The present invention is concerned with methods for the de novo sequencing of polypeptides from data obtained from mass spectrometry devices, particularly from (MS)n devices.

Abstract: The invention relates to compositions and methods for treating an activated B-Cell Diffuse Large B-Cell Lymphoma (ABC-DLBCL). Specifically, the invention relates to treating ABC-DLBCL by administering an NF-?B Essential Modulator (NEMO) Binding Domain (NBD) peptide or a mimetic thereof that inhibits NF-?B activation.

Abstract: One nonlimiting embodiment is directed to an anchor extender releasably engaged with an anchor configured for engagement with one or more bones or bony portions. The anchor extender generally includes a first member and a second member positioned about and movable relative to the first member. The anchor extender is positionable adjacent the anchor and movement of the second member relative to the first member toward the anchor as the anchor extender is engaged with the anchor results in lateral displacement of the anchor extender relative to the anchor while the first member engages with a first side of the anchor and the second member engages with an opposite second side of the anchor. However, in other embodiments, different forms and applications are envisioned.

Abstract: In-line inspection methods are provided. The methods comprise measuring at least two parameters/properties of a prepreg and/or laminate during the manufacture thereof. In some embodiments, the data collected using the inline inspection methods may be processed and/or provided to a manual or automated controller, in order to provide a closed loop method for the manufacture of the prepregs and/or laminates. Apparatus for carrying out the methods are also provided, as are articles comprising a prepreg and/or laminate made using the apparatus.

Abstract: A method can include, for a predetermined route, automatically processing a first set of machine instructions to create a visual travel guide for the predetermined route, the visual travel guide comprising a second set of machine instructions adapted to cause an information device to render: an identification of a destination of the predetermined route; a plurality of videos, each video corresponding to a road intersection located approximately on the predetermined route, each video adapted to substantially reproduce a view of a driver of an automobile approaching the road intersection; a plurality of textual descriptions associated with the plurality of videos; at least one of an identification of an origin of the predetermined route and an identification of an approach to the destination; and an advertisement associated with at least a portion of the predetermined route.

Abstract: A method can include, for a predetermined route, automatically processing a first set of machine instructions to create a visual travel guide for the predetermined route, the visual travel guide comprising a second set of machine instructions adapted to cause an information device to render: an identification of a destination of the predetermined route; a plurality of videos, each video corresponding to a road intersection located approximately on the predetermined route, each video adapted to substantially reproduce a view of a driver of an automobile approaching the road intersection; a plurality of textual descriptions associated with the plurality of videos; at least one of an identification of an origin of the predetermined route and an identification of an approach to the destination; and an advertisement associated with at least a portion of the predetermined route.

Abstract: One non-limiting embodiment is directed to a reduction instrument releasably engageable with a bone anchor and structured to reduce a connecting element into a receiving member of the bone anchor. The reduction instrument includes a first member and a second member laterally movable relative to the first member between a first position for receiving a portion of the bone anchor and a second position for engaging the reduction instrument with the bone anchor. The reduction instrument also includes an actuating member axially displaceable relative to the first and second members. Additionally, the second member is moved between the first and second positions upon displacement of the actuating member relative to the first and second members, and the second member extends substantially parallel to the first member as it is moved between the first and second positions.

Abstract: The invention relates to a windshield wiper device (100) comprising a driving means (110) and a control unit (130) for the driving means (110). An operating characteristic map (140) is provided, in which a maximum torque to be output by the driving means (110) and a minimum rotational speed of the driving means (110) are stored.

Abstract: An apparatus for attachment to a vertebral body for correcting spinal deformities. The apparatus has a plate member having an upper surface and a lower surface. The upper surface having at least one receiving member defining a channel for receiving a flexible connection member. The at least one receiving member having a proximal portion and a distal portion. The proximal and distal portions interfacing along a frangible connection such that the at least one receiving member extends axially from the upper surface a first distance when the frangible connection is unbroken and the at least one receiving member extends axially from the upper surface a second distance when the frangible connection is broken. The second distance is less than the first distance.

Abstract: The present invention is concerned with methods for the selection of precursor ions of a sample polypeptide for fragmentation in mass spectrometry, together with methods for determining at least one putative amino acid sequence for a sample polypeptide, apparatus and computer programs for same.

Abstract: A process for electrolyzing a material to change at least a portion of the material from a first chemical state to a second chemical state includes placing a known quantity of a first substance into either a mixing chamber or an electrolysis chamber of an integrated electrochemical reactor, placing a known quantity of a second substance into the other chamber free of the first substance; sealing an opening to isolate an internal volume within the reactor; rotating the reactor to form a mixture, rotating the reactor again such that the mixture is transferred to the electrolysis chamber; electrolyzing the mixture in the electrolysis chamber to change at least a portion of the mixture from the first chemical state to the second chemical state; and analyzing the first substance, or analyzing the second substance, or analyzing the first chemical state, or analyzing the second chemical state, or any analytical combinations thereof.

Abstract: A system of monitoring operation for a conveyor belt installation includes a conveyor belt having steel or other relatively magnetically permeable reinforcing material, the system including, in proximity to the conveyor belt, a magnetic field generator, and a sensor unit at a position downstream from the field generator, the sensor unit sensing the magnetic field emanating from the passing conveyor belt, and a monitoring unit to receive data related to the magnetic field properties sensed by the sensor unit during a plurality of passages of each part of the length of the conveyor belt past the sensor unit, the monitoring unit incorporating comparison elements to compare a received set of data with an earlier received set of data, and output elements to provide an output signal representative of reinforcement damage or deterioration when subsequently received data has departed from earlier received data by more than a prescribed extent.

Abstract: There is provided an orthopedic plate and port structures for the plate. The plate can be non-rigid and includes at least one hole for receiving an anchor or an anchor retaining device. The at least one hole can include a rigid port structure that prevents or resists deformation of the plate when the anchor or anchor retaining device is engaged thereto.

Abstract: Skeletal stabilization systems include a base, a longitudinal member, and a retaining member. The base includes an engagement surface with a surface area that is positionable in contact with a bone to atraumatically or traumatically engage the base to the bone. The retaining member engages the base to retain the longitudinal member relative to the base so that the longitudinal member can provide a desired stabilization effect to one or more adjacent bony portions.

Abstract: The present invention is concerned with methods for the selection of precursor ions of a sample polypeptide for fragmentation in mass spectrometry, together with methods for determining at least one putative amino acid sequence for a sample polypeptide, apparatus and computer programs for same.

Abstract: A plating system and method include a bone plate with at least a first vertebral engaging portion and a second vertebral engaging portion connected by flexible intermediate portions to permit translation of the vertebrae to which the bone plate is attached. The bone plate may further include a guide assembly extending between the vertebral engaging portions that permits at least uni-directional translation while enhancing resistance of the bone plate to bending forces.

Abstract: The present invention is concerned with methods for the selection of precursor ions of a sample polypeptide for fragmentation in mass spectrometry, together with methods for determining at least one putative amino acid sequence for a sample polypeptide, apparatus and computer programs for same.

Abstract: Skeletal stabilization systems include a base, a longitudinal member, and a retaining member. The base includes an engagement surface with a surface area that is positionable in contact with a bone to atraumatically or traumatically engage the base to the bone. The retaining member engages the base to retain the longitudinal member relative to the base so that the longitudinal member can provide a desired stabilization effect to one or more adjacent bony portions.

Abstract: A vertebral rod connector includes a first portion configured to engage a fastener construct and define a first longitudinal axis. A second portion is configured to engage a vertebral rod and define a second longitudinal axis disposed transverse to the first longitudinal axis. A flexible linking portion is disposed for connecting the first portion with the second portion. The linking portion has a bifurcated configuration oriented transverse to the first longitudinal axis. Methods of use are disclosed.

Abstract: An apparatus for attachment to a vertebral body for correcting spinal deformities. The apparatus has a plate member having an upper surface and a lower surface. The upper surface having at least one receiving member defining a channel for receiving a flexible connection member. The at least one receiving member having a proximal portion and a distal portion. The proximal and distal portions interfacing along a frangible connection such that the at least one receiving member extends axially from the upper surface a first distance when the frangible connection is unbroken and the at least one receiving member extends axially from the upper surface a second distance when the frangible connection is broken. The second distance is less than the first distance.