Abstract: The present invention concerns a polynucleotide construct encoding a mini-receptor of SORLA. The present invention further concerns a vector, a cell and/or a composition comprising said polynucleotide construct. The present invention further concerns a polypeptide representing a mini-receptor of SORLA. The present invention further concerns said vector, said cell and/or said composition comprising said poly nucleotide construct, for use in medicine. The present invention further concerns said vector, said cell and/or said composition comprising said polynucleotide construct, for use in treatment, prevention and/or alleviation of Alzheimer's Disease or a disease or disorder associated with Alzheimer's Disease. The present invention further concerns a method of treating Alzheimer's Disease or a disease or disorder associated with Alzheimer's Disease. The present invention further concerns a method of increasing sAPP? in a cell.

Abstract: The present disclosure concerns antisense oligonucleotide (ASO) capable of binding to a target site on the pre-mRNA of SORL1. The present disclosure further concerns a composition comprising said ASO. The present disclosure further concerns an ASO for use in medicine. The present disclosure further concerns an ASO for use in the prevention, treatment and/or alleviation of Alzheimer's Disease (AD), or a disease or disorder associated with Alzheimer's Disease. The present disclosure further concerns a method for mediating exon skipping in SORL1 transcripts, a method of determining the efficiency of ASO mediated SORL1 exon skipping, a method for testing if a patient identified with a SORL1 mutation will benefit from treatment with an ASO mediating exon skipping, and a method of producing an ASO.

Abstract: This disclosure relates generally to systems, devices, and methods of use thereof regarding headrests for selectively removable spa seatbacks. In some embodiments, headrests of the present disclosure include a pillow and a manifold to (a) receive the pillow and (b) selectively engage the selectively removable spa seatback. In some embodiments, headrests of the present disclosure include a pillow and a manifold, where the manifold includes a platform to receive the pillow, a body for engaging with the selectively removable spa seatback, and a constraining plate to restrict a movement of a portion of the body.

Abstract: This disclosure relates generally to induction systems for wirelessly transmitting electricity. Specifically, embodiments of the present disclosure relate to methods and systems for wirelessly transmitting electricity to a light incorporated within, for example, a spa. In some embodiments, the systems include at least one pair of induction coils (e.g., receiving and transmitting coils) incorporated into a selectively removable spa seatback. The at least one pair of induction coils can be used to wirelessly transmit electricity to a light disposed within the selectively removable spa seatback. In some embodiments, a converter is incorporated into the system to adjust at least one characteristic of the light, such as brightness, color, and/or a lighting pattern.

Abstract: This disclosure relates generally to jets for spas and, more specifically, to jets that can have more than one jet hydrotherapy spray mode. The jet can include a selectively rotatable jet head, the jet head having a first jet spray mode and a second jet spray mode. The jet head includes a valve, the valve having a first water inlet and a second water inlet, the valve further comprising a first air channel and a second air channel. The valve is rotatable from a first jet spray mode position in which a water intake is in fluid communication with the first water inlet and an air intake is in fluid communication with the first air channel, to a second jet spray mode position in which the water intake is in fluid communication with the second water inlet and the air intake is in fluid communication with the second air channel.

Abstract: This disclosure relates generally to jets for spas and, more specifically, to jets that can be adjusted laterally along a width of the proximal end of the jet housing. The angular adjustment of the proximal outlet of the jet may be at least 30°. In some embodiments, the jet assembly includes a housing with a distal inlet at a distal end of the housing and a proximal outlet at a proximal end of the housing, the proximal outlet laterally adjustable along a width of the proximal end of the housing, with the proximal outlet maintaining a constant depth with respect to the proximal end of the housing as the proximal outlet is laterally adjusted along the width of the proximal end of the housing.

Abstract: The present invention relates to a system for electrical energy storage. More specifically, the system comprises an energy storage retrofitted to an existing photovoltaic system. The present invention further relates to a method for control such a system for electrical energy storage.

Abstract: This disclosure relates generally to induction systems for wirelessly transmitting electricity. Specifically, embodiments of the present disclosure relate to methods and systems for wirelessly transmitting electricity to a light incorporated within, for example, a spa. In some embodiments, the systems include at least one pair of induction coils (e.g., receiving and transmitting coils) incorporated into a selectively removable spa seatback. The at least one pair of induction coils can be used to wirelessly transmit electricity to a light disposed within the selectively removable spa seatback. In some embodiments, a converter is incorporated into the system to adjust at least one characteristic of the light, such as brightness, color, and/or a lighting pattern.

Abstract: The present invention relates to a sorLA-based drug screening platform for use in screening compound libraries for an effect on endosomal activity.

Abstract: A biological sample collection system can include a sample collection vessel having a sample collection chamber with an opening configured to receive a biological sample into the sample collection chamber. The biological sample collection system can additionally include a selectively movable sleeve valve configured to associate with the opening of the sample collection chamber. The biological sample collection system can additionally include a sealing cap that is configured to associate with the selectively movable sleeve valve and with the sample collection vessel. The sealing cap can include a reagent chamber having reagent(s) stored therein, and when the sealing cap is associated with the sample collection vessel, the selectively movable sleeve valve opens, dispensing the reagent(s) into the sample collection chamber.

Abstract: A biological sample collection system can include a sample collection vessel having a sample collection chamber with an opening configured to receive a biological sample into the sample collection chamber. The biological sample collection system can additionally include a selectively movable sleeve valve configured to associate with the opening of the sample collection chamber. The biological sample collection system can additionally include a sealing cap that is configured to associate with the selectively movable sleeve valve and with the sample collection vessel. The sealing cap can include a reagent chamber having reagent(s) stored therein, and when the sealing cap is associated with the sample collection vessel, the selectively movable sleeve valve opens, dispensing the reagent(s) into the sample collection chamber.

Abstract: A biological sample collection system can include a sample collection vessel having a sample collection chamber with an opening configured to receive a biological sample into the sample collection chamber. The biological sample collection system can additionally include a selectively movable sleeve valve configured to associate with the opening of the sample collection chamber. The biological sample collection system can additionally include a sealing cap that is configured to associate with the selectively movable sleeve valve and with the sample collection vessel. The sealing cap can include a reagent chamber having reagent(s) stored therein, and when the sealing cap is associated with the sample collection vessel, the selectively movable sleeve valve opens, dispensing the reagent(s) into the sample collection chamber.

Abstract: A biological sample collection system can include a sample collection vessel having a sample collection chamber with an opening configured to receive a biological sample into the sample collection chamber. The biological sample collection system can additionally include a selectively movable sleeve valve configured to associate with the opening of the sample collection chamber. The biological sample collection system can additionally include a sealing cap that is configured to associate with the selectively movable sleeve valve and with the sample collection vessel. The sealing cap can include a reagent chamber having reagent(s) stored therein, and when the sealing cap is associated with the sample collection vessel, the selectively movable sleeve valve opens, dispensing the reagent(s) into the sample collection chamber.

Abstract: An improved system and method for sensing the location of a tree trunk relative to an orchard harvester machine that generally includes a distance sensor, a vegetation pushing device that functions to displace vegetation, such as low-hanging tree branches, grass or other upward-growing vegetation which may obscure the sensor's detection of the tree trunk, and a controller in communication with the distance sensor, which system may be incorporated into existing tree harvesters such as those with mechanized tree shakers, and may also be incorporated into a catching frame vehicle or a nut sweeping vehicle.

Abstract: A system for sensing the location of a tree trunk relative to an orchard harvester, which includes a body, including a distance sensor mounted on the body, a boom movably connected to the body, a tree shaker head having two opposed jaws and rotatably connected to the boom and a programmable controller in communication with the distance sensor, the controller programmed to manipulate the angle at which the distance sensor measures distance as determined by a measured height at which the shaker head jaws will clamp a proximate tree.