Abstract: Disclosed are quinoline and quinazoline compounds which modulate the activity of the gated ion channels. Compounds that modulate these gated ion channels are useful in the treatment of diseases and disorders related to pain, inflammation, the neurological system, the gastrointestinal system and genitourinary system. Preferred compounds include quinoline or quinazoline derivatives substituted at the 4-position via N(H), C(O) or O moieties.

Abstract: Crosslinked polyether siloxane block copolymers are obtained by reacting an alpha-omega hydrogen siloxane with at least one higher-order hydrogen siloxane and at least one polyether in the presence of a hydrosilylation catalyst. These are described, and also use thereof as additives for producing polyurethane foams, particularly mechanically foamed polyurethane foams.

Abstract: The present disclosure provides a chewable composition for teeth-whitening, comprising a first chewable composition and a second chewable composition, that when combined in the mouth and actuated by mastication provide cosmetic enhancement and chemotherapeutic activity. In some aspects, the first chewable composition comprises carbamide peroxide having water content of about 2% or less, an anhydrous chewing gum base having water content of about 2% or less, and tableting excipients having a water content of 2% or less; and the second chewable composition comprises a gum base, a source of bicarbonate ion, and one or more gum additives. The disclosure also provides a kit comprising the first and second separate chewable compositions, and methods for whitening teeth and freshening the breath, and also for reducing the levels of the oral pathogen sources of periodontal diseases and halitosis using the compositions and kits described herein.

Abstract: A recoil device is provided for a gun having a barrel with a breech. The device includes a breech nut, a brake assembly, a pneumatic spring and a counter-recoil buffer. The breech nut has first and second adjacent sides. The brake assembly includes a brake cylinder that mounts to the breech nut on the first side. The pneumatic spring mounts to the breech nut on the second side. The counter-recoil buffer attaches to the pneumatic spring. The brake cylinder and the pneumatic spring internally push fluids for recoil absorption and return in response to firing the gun.

Abstract: In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. The mutant toxin may include a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to methods and compositions for use in culturing Clostridium difficile and in producing C. difficile toxins.

Abstract: The present disclosure provides, inter alia, a method for making a solid fermented product useful for animal feed comprising the steps of adding a source of calcium to a fermented liquid comprising ammonium lactate.

Abstract: The use of long-chain citric acid esters as additives in aqueous polymer dispersions for production of porous polymer coatings, preferably for production of porous polyurethane coatings, is described.

Abstract: Merchants provide incentives for customer transactions on accounts issued to them by issuers. Incentives include a merchant making a donation to entities with whom the merchants and/or the consumers have an affinity such as residence in the community. Each merchant can define the donation to be percentage of the transaction amount. Cryptographically secure chains are provided for uniquely labeling each such transaction and each such donation by way of incorporating role-based digital wallets and multiple synchronized transactional blockchains. Where the donations are used to purchase an Internet-of-Things (IOT) enabled system, real and/or near-real time usage information can be received and transmitted to the logical addresses of the customers and or the merchants so as to confirm efficacy of the donations.

Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted thieno[3,2-b]pyridine compounds, forms, and pharmaceutical compositions thereof.

Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted pyrrolo[2,3-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.

Abstract: The present description relates to methods of treating spinocerebellar ataxia type 3 (SCA3) using substituted thieno[3,2-d]pyrimidine compounds, forms, and pharmaceutical compositions thereof.

Abstract: A connector for connecting a frame member to one or more other frame members of a space frame assembly is disclosed. The connector includes a body defining a surface and a projection extending outwardly from the surface along a main axis to define an axial end surface away from the surface. The axial end surface defines a curvature having continuity across an expanse of the axial end surface to facilitate formation of a full penetration weld joint between an end of the frame member and the axial end surface upon a contact of the end of the frame member with the axial end surface.

Abstract: Systems and methods for dynamically generating object models corresponding to regulations. According to certain aspects, a server computer may access a regulation and automatically generate a summary of the regulation based on a specific set of sentences. The server computer may additionally determine a set of topics and named-entity attributes for text within a regulation object model, as well as a probability that a topic or attribute is applicable to the regulation. Further, the server computer may generate and enrich object models according to the various analyses and avail the enriched object models for review by entities and users of regulatory compliance services.

Abstract: Techniques are disclosed for systems associated with lightweight docking stations for one or more micromobility transit vehicles. The docking station may include multiple racks. Each rack may include a base frame having frame segments, an anchor coupled to and extending vertically from at least one of the frame segments of the base frame, and a lock plate coupled to the anchor and including a lock hole. The lock hole is disposed through the lock plate and is capable of receiving a locking device associated with a micromobility transit vehicle so as to permit locking of the micromobility transit vehicle to the anchor.

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted bicyclic heterocyclic and heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Abstract: Systems and methods for dynamically generating object models corresponding to regulations. According to certain aspects, a server computer may access a regulation and automatically generate a summary of the regulation based on a specific set of sentences. The server computer may additionally determine a set of topics and named-entity attributes for text within a regulation object model, as well as a probability that a topic or attribute is applicable to the regulation. Further, the server computer may generate and enrich object models according to the various analyses and avail the enriched object models for review by entities and users of regulatory compliance services.

Abstract: A chewable composition for teeth-whitening comprising a first region and a second region separated by a barrier layer; the first region comprising carbamide peroxide having water content of about 2% or less, a wetting agent (e.g., glycerin), an anhydrous chewing gum base having water content of about 1% or less, an anhydrous fruit acid, and one or more gum additives; and the second region comprising a chewable composition comprising a gum base, a source of bicarbonate ion, and one or more gum additives. A kit comprising separate chewable compositions corresponding to the first and second regions, and methods for whitening teeth using the chewable composition are also provided.

Abstract: A chewable composition for teeth-whitening comprising a first region and a second region separated by a barrier layer; the first region comprising carbamide peroxide having water content of about 2% or less, a wetting agent (e.g., glycerin), an anhydrous chewing gum base having water content of about 1% or less, an anhydrous fruit acid, and one or more gum additives; and the second region comprising a chewable composition comprising a gum base, a source of bicarbonate ion, and one or more gum additives. A kit comprising separate chewable compositions corresponding to the first and second regions, and methods for whitening teeth using the chewable composition are also provided.

Abstract: Disclosed herein are methods and systems for determining an attribute of an object at a pre-determined time point. Data representing a respective property of the object and a plurality of further objects at a plurality of time points different from the pre-determined time point are determined, and the data is arranged in an image-like data structure. The image-like data structure has a plurality of columns and a plurality of rows. The data is arranged in the image-like data structure such that each of one of the rows or the columns corresponds to respective properties of the object or of one of the plurality of further objects and each of the other of the rows or the columns corresponds to respective properties at one of the plurality of time points. The attribute is then determined using a pre-determined rule based on the image-like data structure.

Abstract: A chewable composition for teeth-whitening comprising a first region and a second region separated by a barrier layer; the first region comprising carbamide peroxide having water content of about 2% or less, a wetting agent (e.g., glycerin), an anhydrous chewing gum base having water content of about 1% or less, an anhydrous fruit acid, and one or more gum additives; and the second region comprising a chewable composition comprising a gum base, a source of bicarbonate ion, and one or more gum additives. A kit comprising separate chewable compositions corresponding to the first and second regions, and methods for whitening teeth using the chewable composition are also provided.