Abstract: Compositions such as pharmaceutical compositions and uses for peptide-drug conjugates are disclosed. Such compositions can deliver a drug, a peptide, or a conjugate thereof to a target region, tissue, structure or cell in cartilage.

Abstract: A keyboard interface enables the efficient selection of one or more data items from a set of data items. The appearance of the keyboard interface can be dynamically generated and updated based on characteristics of the data items in the set. When a user selects a user interface element associated with a set of data items, the data items in the set can be evaluated to determine a number of keys to include in the keyboard interface as well as which characters are assigned to each included key. The number of keys and which characters are assigned to these keys can be determined by identifying a first character in each of the data items in the set. When the user selects a key, the keyboard interface can be updated in a similar manner but based on characters at a subsequent position in data items that matched the previously selected key.

Abstract: A keyboard interface enables the efficient selection of one or more data items from a set of data items. The appearance of the keyboard interface can be dynamically generated and updated based on characteristics of the data items in the set. When a user selects a user interface element associated with a set of data items, the data items in the set can be evaluated to determine a number of keys to include in the keyboard interface as well as which characters are assigned to each included key. The number of keys and which characters are assigned to these keys can be determined by identifying a first character in each of the data items in the set. When the user selects a key, the keyboard interface can be updated in a similar manner but based on characters at a subsequent position in data items that matched the previously selected key.

Abstract: An ultrasonic and electrosurgical handpiece housing has an axis, a distal end, a proximal end and a passage defined by an inside wall. A piezo stack has elements carried along a plane generally transverse to the axis. A retainer for the elements has distal, intermediate and proximal portions. The distal portion has a fastener; the proximal portion has a threaded shoulder bolt. The stack about the shoulder has an energy input and a reference output positioned axially apart from one another. An insulating sleeve about the bolt is between central openings of the elements and the bolt. A pair of insulators about the bolt has the stack therebetween; one insulator is between the plane and the stack and the other is near the threads. The intermediate portion attaches to the housing at the plane with decoupling and sealing. An irrigation channel conveys fluid. The drive energy input, the feedback signal and the reference outputs are insulated by the sleeve and pair from the bolt.