Abstract: Modified canine leptin polypeptides and formulations and uses thereof, are provided including polyethylene glycol (PEG) modified canine leptin polypeptides, wherein the PEG moiety is covalently attached to a para-acetyl-phenylalanine (pAF) residue of the polypeptide, and related compositions and methods useful in treating companion animal obesity and other leptin-related disorders.

Abstract: An acceleration and braking mechanism kit autonomously controls a vehicle brake pedal and a vehicle accelerator pedal. The kit includes a support bracket and bell crank supported on the support bracket for connection with an acceleration pedal or a brake pedal of the vehicle. An actuator is connected to the bell crank for moving the bell crank. A first base bracket is configured to mount to a first vehicle. A second base bracket is configured to mount to a second vehicle. The first base bracket and the second base bracket each include a mounting feature. The support bracket includes a mounting base alternately engageable with the mounting feature of the first base bracket and the mounting feature of the second base bracket such that the support bracket may be mounted to the first base bracket in the first vehicle or to the second base bracket in the second vehicle.

Abstract: An acceleration and braking mechanism kit autonomously controls a vehicle brake pedal and a vehicle accelerator pedal. The kit includes a support bracket and bell crank supported on the support bracket for connection with an acceleration pedal or a brake pedal of the vehicle. An actuator is connected to the bell crank for moving the bell crank. A first base bracket is configured to mount to a first vehicle. A second base bracket is configured to mount to a second vehicle. The first base bracket and the second base bracket each include a mounting feature. The support bracket includes a mounting base alternately engageable with the mounting feature of the first base bracket and the mounting feature of the second base bracket such that the support bracket may be mounted to the first base bracket in the first vehicle or to the second base bracket in the second vehicle.

Abstract: Modified canine leptin polypeptides and formulations and uses thereof, are provided including polyethylene glycol (PEG) modified canine leptin polypeptides, wherein the PEG moiety is covalently attached to a para-acetyl-phenylalanine (pAF) residue of the polypeptide, and related compositions and methods useful in treating companion animal obesity and other leptin-related disorders.

Abstract: A board game has first and second playing areas, with the first playing area being a continuous path along the perimeter of the game board. The second playing area is located within the first playing area and includes spaces for forming words with the spaces having a surface for erasable markings of letters. The first and second playing areas have indicia printed thereon. The first playing area determines which letters to use to form words within the second playing area, and indicates the monetary values for using the indicated letters. The board game also includes a die that controls the movement of player pieces along the continuous path and which directs the players to use a spinner of the board game. Words may be formed within the second playing area and can be spelled forward, backward, vertically, horizontally or diagonally. The spinner provides a further random chance control.