Abstract: A computer-aided design system enables physical articles to be customized via printing or embroidering and enables digital content to be customized and electronically shared. A user interface may be generated that includes an image of a model of an article of manufacture and user customizable design areas that are graphically indicated on the image corresponding to the model. A design area selection may be received. In response to an add design element instruction and design element specification, the specified design element is rendered in the selected design area on the model image. Customization permissions associated with the selected design area are accessed, and using the customization permissions, a first set of design element edit tools are selected and rendered. User edits to the design element may be received and rendered in real time. Manufacturing instructions may be transmitted to a printing system.

Abstract: A refrigerator having an ice and water dispenser has a seal to sealingly engage the ice compartment when the refrigerator door is closed. The seal is flexible to accommodate manufacturing tolerance. The seal may be impregnated with a friction reducing agent to increase life of the seal.

Abstract: A rodless guide microwave radiation device, system, and method is disclosed for measuring at least one characteristic of a liquid in a vessel. A hollow metal waveguide conveys microwave radiation and is adapted to be disposed in a vessel for containing a liquid, the waveguide having a first end and a second end. A single chip radar sensor mounted on a PCB is disposed proximal to the first end of the hollow waveguide. The radar sensor is configured to transmit millimeter wavelength signals into the first end of the hollow waveguide for propagating down the waveguide toward the second end, and receive a return echo from the signal based upon a change in impedance upon encountering the liquid and propagating in the reverse direction of the waveguide, the single chip radar sensor including electronic circuitry for determining at least one characteristic of the liquid located in the waveguide based on detection of an impedance change according to time domain reflectometry.

Abstract: A computer-aided design system enables physical articles to be customized via printing or embroidering and enables digital content to be customized and electronically shared. A user interface may be generated that includes an image of a model of an article of manufacture and user customizable design areas that are graphically indicated on the image corresponding to the model. A design area selection may be received. In response to an add design element instruction and design element specification, the specified design element is rendered in the selected design area on the model image. Customization permissions associated with the selected design area are accessed, and using the customization permissions, a first set of design element edit tools are selected and rendered. User edits to the design element may be received and rendered in real time. Manufacturing instructions may be transmitted to a printing system.

Abstract: A computer-aided design (CAD) system enables physical articles to be customized via printing or embroidering and enables digital content to be customized and electronically shared. A CAD user interface may be generated that includes an image of a model of an article of manufacture and a customizable template. The customizable template may include user customizable design areas. One or more defined rules associated with respective customizable areas may be accessed. In response to a user selection of a default content item and a corresponding rule, content items may be automatically used to populate other template design areas and/or change a color of one or content items. Manufacturing instructions corresponding to the user customizations may be transmitted to a printing system using a file that includes location, rotation, and/or scale data.

Abstract: A computer-aided design (CAD) system enables physical articles to be customized via printing or embroidering and enables digital content to be customized and electronically shared. A CAD user interface may be generated that includes an image of a model of an article of manufacture and a customizable template. The customizable template may include user customizable design areas. One or more defined rules associated with respective customizable areas may be accessed. In response to a user selection of a default content item and a corresponding rule, content items may be automatically used to populate other template design areas and/or change a color of one or content items. Manufacturing instructions corresponding to the user customizations may be transmitted to a printing system using a file that includes location, rotation, and/or scale data.

Abstract: Disclosed herein are compounds according to Formula I; a pharmaceutical composition including, consisting essentially of, or consisting of: a pharmaceutically acceptable compound of Formula I and a pharmaceutically acceptable carrier, diluent, or excipient; the use of compounds of Formula I in the preparation of a medicament; and a method including administering a pharmaceutical compositions comprising the compound of Formula I to a patient. The compounds, compositions, use, and methods are directed to the treatment of neurological, psychiatric disorders which are characterised by a fundamental disruption of social behaviour, and substance use disorders.

Abstract: Provided herein are methods, kits and reagents for analyzing attributes of engineered immune cells, such as CAR T cells. For example, provided herein are methods of determining the amount or percentage of residual TCR??+ CAR T cells in allogeneic CAR T cell drug product and characterizing other important attributes of CAR T cell drug product.

Abstract: A computer-aided design system enables physical articles to be customized via printing or embroidering and enables digital content to be customized and electronically shared. A user interface may be generated that includes an image of a model of an article of manufacture and user customizable design areas. Customization permissions associated with a selected design area are accessed. User provided content to be used in customizing a design area may be analyzed in real time or in batch mode using a trained engine to determine if it complies with one or more rules. If the user provided content satisfies a corresponding rule, manufacturing instructions and a design file may be transmitted to a printing system.

Abstract: A computer-aided design (CAD) system utilizes an image analysis engine to identify objects in a video frame. Customization rules and object identifiers assigned by the image analysis engine and associated with the frame are used to determine if the frame is permitted to be used to customize a product. If the frame is not permitted to be used, an indicator is stored configured to inhibit the frame from being used to customize the product and/or cause the frame to be edited to obscure frame objects. A user request is received for the product. A determination is made as to what frames have been used to customize instances of the product. A first frame is selected that has not been used to customize physical instances of the product. The first frame is printed on the product. The first frame is inhibited from being used to customize other instances of the product.

Abstract: A computer-aided design (CAD) system enables physical articles to be customized via printing or embroidering and enables digital content to be customized and electronically shared. A CAD user interface may be generated that includes an image of a model of an article of manufacture and a customizable template. The customizable template may include user customizable design areas. One or more defined rules associated with respective customizable areas may be accessed. In response to a user selection of a default content item and a corresponding rule, content items may be automatically used to populate other template design areas and/or change a color of one or content items. Manufacturing instructions corresponding to the user customizations may be transmitted to a printing system using a file that includes location, rotation, and/or scale data.

Abstract: A computer-aided design system enables physical articles to be customized via printing or embroidering and enables digital content to be customized and electronically shared. A user interface may be generated that includes an image of a model of an article of manufacture and user customizable design areas that are graphically indicated on the image corresponding to the model. A design area selection may be received. In response to an add design element instruction and design element specification, the specified design element is rendered in the selected design area on the model image. Customization permissions associated with the selected design area are accessed, and using the customization permissions, a first set of design element edit tools are selected and rendered. User edits to the design element may be received and rendered in real time. Manufacturing instructions may be transmitted to a printing system.

Abstract: A computer-aided design system enables physical articles to be customized via printing or embroidering. A user interface may be generated that includes an image of a model of an article of manufacture and user customizable design areas that are graphically indicated on the image corresponding to the model. A design area selection may be received. In response to an add design element instruction and design element specification, the specified design element is rendered in the selected design area on the model image. Customization permissions associated with the selected design area are accessed, and using the customization permissions, a first set of design element edit tools are selected and rendered. User edits to the design element may be received and rendered in real time. Manufacturing instructions may be transmitted to a printing system.

Abstract: A computer-aided design system enables physical articles to be customized via printing or embroidering and enables digital content to be customized and electronically shared. A user interface may be generated that includes an image of a model of an article of manufacture and user customizable design areas. Customization permissions associated with a selected design area are accessed. User provided content to be used in customizing a design area may be analyzed in real time or in batch mode using a trained engine to determine if it complies with one or more rules. If the user provided content satisfies a corresponding rule, manufacturing instructions and a design file may be transmitted to a printing system.

Abstract: A refrigerator having an ice and water dispenser has a seal to sealingly engage the ice compartment when the refrigerator door is closed. The seal is flexible to accommodate manufacturing tolerance. The seal may be impregnated with a friction reducing agent to increase life of the seal.

Abstract: A computer-aided design (CAD) system enables physical articles to be customized via printing or embroidering and enables digital content to be customized and electronically shared. A CAD user interface may be generated that includes an image of a model of an article of manufacture and a customizable template. The customizable template may include user customizable design areas. One or more defined rules associated with respective customizable areas may be accessed. In response to a user selection of a default content item and a corresponding rule, content items may be automatically used to populate other template design areas and/or change a color of one or content items. Manufacturing instructions corresponding to the user customizations may be transmitted to a printing system using a file that includes location, rotation, and/or scale data.

Abstract: The present invention is directed to methods of screening populations of transgenic cells for cells that produce a protein of interest. The methods comprise culturing transgenic cells in culture conditions that include at least one non-natural amino acid (nnAA) in the cell culture medium. The transgenic cells comprise at least one polynucleotide that codes for a fusion protein with a first domain coding for a protein of interest and a second domain coding for a domain that facilitates detection of the transgenic cells that express the protein of interest when the transgenic cell expresses the second domain.

Abstract: A computer-aided design system enables physical articles to be customized via printing or embroidering and enables digital content to be customized and electronically shared. A user interface may be generated that includes an image of a model of an article of manufacture and user customizable design areas that are graphically indicated on the image corresponding to the model. A design area selection may be received. In response to an add design element instruction and design element specification, the specified design element is rendered in the selected design area on the model image. Customization permissions associated with the selected design area are accessed. User edits to the design element may be received and rendered in real time. Manufacturing instructions may be transmitted to a printing system using a file that includes location, rotation, and/or scale data.

Abstract: A computer-aided design (CAD) system enables physical articles to be customized via printing or embroidering and enables digital content to be customized and electronically shared. A CAD user interface may be generated that includes an image of a model of an article of manufacture and a customizable template. The customizable template may include user customizable design areas. One or more defined rules associated with respective customizable areas may be accessed. In response to a user selection of a default content item and a corresponding rule, content items may be automatically used to populate other template design areas and/or change a color of one or content items. Manufacturing instructions corresponding to the user customizations may be transmitted to a printing system using a file that includes location, rotation, and/or scale data.

Abstract: A refrigerator having an ice and water dispenser has a seal to sealingly engage the ice compartment when the refrigerator door is closed. The seal is flexible to accommodate manufacturing tolerance. The seal may be impregnated with a friction reducing agent to increase life of the seal.