Abstract: The invention provides methods of treatment of ocular disorders, including ocular disease with an angiogenic component. In certain embodiments, the treatment comprises administration of a ROCK2 inhibitor and an angiogenesis inhibitor. In certain embodiments, the ROCK2 inhibitor is ROCK2 selective. In certain embodiments, the angiogenesis inhibitor is a VEGF antagonist, for example, and VEGFR2 antibody.

Abstract: A hydration system includes a refillable flexible liquid container or bag that is suspended from the shoulders much like a hiker's back pack with the weight of the liquid disposed on a centered position at the anatomic pivot point in the small of the back of the user. A trigger-actuated pump type liquid dispenser is attached to the bottom of the bag by a kink-free flexible coiled tube. The dispenser includes a nozzle that is adjustable between "stream" and "spray" positions, and has a hook and loop patch thereon which cooperates with a similar patch on a front strap of the suspension system for the ready attachment of the dispenser to the front strap of the suspension system and the removal of the dispenser therefrom. In a modification the walls of the container are insulated in order to maintain the temperature of the contents at a desired level.