Abstract: The invention provides methods of treatment of ocular disorders, including ocular disease with an angiogenic component. In certain embodiments, the treatment comprises administration of a ROCK2 inhibitor and an angiogenesis inhibitor. In certain embodiments, the ROCK2 inhibitor is ROCK2 selective. In certain embodiments, the angiogenesis inhibitor is a VEGF antagonist, for example, and VEGFR2 antibody.

Abstract: The metronome serves for the optical and acoustic display of tempo, phase and the division of the phases of music pieces or movement rhythms. The above comprises a housing (1) with a display for the optical display of a movement which describes a curve (3) similar to a parabola. Means for controlling the display are further provided so that the optical movement oscillates with adjustable frequency and with additional means for the selective electrical generation of tones for acoustically marking the inflection points of the movement and for the selective further acoustic division of the time intervals between the inflection points of the movement. The display advantageously comprises a row of discrete light sources (2), arranged along a curve (3) similar to a parabola. The light sources (2) may be controlled such as to generate a moving light which oscillates back and forth along the row of light sources with adjustable frequency.

Abstract: A metronome for an optical and acoustic display of tempo, phase and the division of the phases of musical pieces or movement rhythms includes a housing with a display for the optical display of a movement which describes a curve similar to a parabola and a device for controlling the display, so that the optical movement oscillates with an adjustable frequency. There is preferably a selective electrical generation of tones for acoustically marking the inflection points of the movement and for the selective further acoustic division of the time intervals between the inflection points of the movement. The display may include a row of discrete light sources arranged along a curve similar to a parabola. The light sources may be controlled to generate a moving light which oscillates back and forth along the row of light sources with adjustable frequency.

Abstract: A sound pickup switching apparatus for a string instrument having a plurality of sound pickups, in particular for an electric guitar. The apparatus includes an operable switching device which is intended to connect the coils of the sound pickups in different combinations in order to produce an output signal of different tonality. A voice signal production apparatus, depending on the respective state of the switching device, produces a voice signal designating the state. The string instrument includes a voice signal production apparatus which makes it possible to output states of the string instrument by voice.

Abstract: A hydration system includes a refillable flexible liquid container or bag that is suspended from the shoulders much like a hiker's back pack with the weight of the liquid disposed on a centered position at the anatomic pivot point in the small of the back of the user. A trigger-actuated pump type liquid dispenser is attached to the bottom of the bag by a kink-free flexible coiled tube. The dispenser includes a nozzle that is adjustable between "stream" and "spray" positions, and has a hook and loop patch thereon which cooperates with a similar patch on a front strap of the suspension system for the ready attachment of the dispenser to the front strap of the suspension system and the removal of the dispenser therefrom. In a modification the walls of the container are insulated in order to maintain the temperature of the contents at a desired level.