Abstract: A method of treatment of skin tissue with two laser devices of unequal wavelengths comprising the steps of: (1) activating the two laser devices simultaneously to produce two laser beams of unequal wavelength; (2) directing the two laser beams into a handpiece having a distal tip to direct the laser beams onto the skin tissue; (3) directing the two laser beams within the handpiece to an adjustable beam deflector; and, (4) the adjustable beam deflector directing the two laser beams onto the skin tissue to produce a pattern of laser spots simultaneously but separated from one another.

Abstract: Methods and systems for sharing electronic documents are described herein. The example method includes storing the electronic documents in a relational database storage; storing entity identifiers in the relational database storage, each entity identifier representing an entity type; recording in a non-relational database storage associations between the electronic documents and at least one entity identifier, each association comprising a relationship between a set of electronic documents and the at least one entity identifier; associating a delegate account with the at least one entity identifier; and based on an association recorded in the non-relational database storage for the at least one entity identifier, granting the delegate account a subset of document management functions available for the set of documents.

Abstract: An apparatus for cutting a whole tire into strips may include a cutting device having a first rotary blade and a second rotary blade. The tire is positioned between the first rotary blade and the second rotary blade, which cut the tire into one or more strips. The apparatus may further include a positioning system operable to orient the tire between a plurality of vertical, horizontal, and intermediate positions, relative to the cutting device. The apparatus may include one or more support rollers. The apparatus may further include a control system that controls the operation of the cutting device and tire positioning system as the tire is cut into strips by the cutting device. The apparatus may include a chipper to cut the tire strips into chips. The apparatus may include a bead peeler to remove the exterior rubber sheath from the wire bead.

Abstract: The present disclosure relates to analogs of N-acetyl glucosamine fluorinated at 4- and/or 6-position(s) and derivatives of xylose at anomeric position for the treatment of a neurological disease, inflammation, cancer and a central nervous system injury.

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: The present invention is directed to a capo, or a fretpad for a capo, for use with a stringed musical instrument. The fretpad is manufactured from a pliable material that mimics the compression of a human finger, and which prevents the instrument from going out of tune prematurely. The fretpad insert is radiused and configured to be insertable into a frame, which may be detachably connected to a capo body.

Abstract: A marker band locator system locates a marker band, from a plurality of marker bands in a hopper, into a band receiver for further processing. A hopper is configured to loosely hold a plurality of marker bands and a band receiver, configured in an indexer, is configured under the hopper such that marker bands gravity feed down to the band receiver. A vacuum source produces a vacuum on the band receiver and if a marker band is properly located therein, the marker band forms a seal with the band receiver and the vacuum pressure exceeds a threshold vacuum pressure level. The indexer then actuates to a secondary position for further processing and removal of the marker band. If the vacuum pressure does not exceed the threshold, a burst of air jostles the marker bands in the hopper until a marker band is seated properly.

Abstract: Systems, methods and computer program products for automatically ingesting and filing documents in a database having a plurality of file locations. An electronic file having one or more documents is received. For each document in the received file, text data is identified and used to generate a plurality of suggested file locations for the received documents. Machine learning systems may be used to enhance the accuracy of suggested file locations.

Abstract: An apparatus for cutting a whole tire into strips may include a cutting device having a first rotary blade and a second rotary blade. The tire is positioned between the first rotary blade and the second rotary blade, which cut the tire into one or more strips. The apparatus may further include a positioning system operable to orient the tire between a plurality of vertical, horizontal, and intermediate positions, relative to the cutting device. The apparatus may include one or more support rollers. The apparatus may further include a control system that controls the operation of the cutting device and tire positioning system as the tire is cut into strips by the cutting device. The apparatus may include a chipper to cut the tire strips into chips. The apparatus may include a bead peeler to remove the exterior rubber sheath from the wire bead.

Abstract: A shredder blade assembly is disclosed having a rotor configured to be mounted on a rotating shaft, the rotor having opposing faces with a plurality of angled knife receptacles and a plurality of knife inserts mounted within the plurality of knife receptacles. Each knife insert has two opposing faces and each opposing face comprises three cutting edges such that each knife insert has six cutting edges. Only one of the cutting edges is exposed at an outer peripheral edge of the shredder blade assembly during use. The knife inserts are configured to be removed, rotated (and flipped as needed), and re-mounted within the plurality of knife receptacles to expose another of the cutting edges at the outer peripheral edge of the shredder blade assembly. The knife insert may be triangular and mounted to expose one vertex to create a plurality of tooth/hook projections.

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g.

Abstract: Systems and methods are disclosed that cause a transient exchange ratio between digital assets at a kiosk, together with a countdown timer or other indication of how much time remains within which the ratio applies. If a transaction proceeds a voucher may be dispensed to confirm it. If a transaction participant using the kiosk is not yet vetted, the transaction is nevertheless deemed inchoate, and a prolonged vetting begins.

Abstract: A forming machine for erecting a packaging article, the machine comprising a female cavity and a plunger which moves up and down in a generally vertical cycle and which can push a packaging article down into the cavity when moving down, in which the plunger is driven to move up and is not driven to move down.

Abstract: Systems, methods and computer program products for automatically ingesting and filing documents in a database having a plurality of file locations. An electronic file having one or more documents is received. For each document in the received file, text data is identified and used to generate a plurality of suggested file locations for the received documents. Machine learning systems may be used to enhance the accuracy of suggested file locations.

Abstract: A shredder blade assembly is disclosed having a rotor configured to be mounted on a rotating shaft, the rotor having opposing faces with a plurality of angled knife receptacles and a plurality of knife inserts mounted within the plurality of knife receptacles. Each knife insert has two opposing faces and each opposing face comprises three cutting edges such that each knife insert has six cutting edges. Only one of the cutting edges is exposed at an outer peripheral edge of the shredder blade assembly during use. The knife inserts are configured to be removed, rotated (and flipped as needed), and re-mounted within the plurality of knife receptacles to expose another of the cutting edges at the outer peripheral edge of the shredder blade assembly. The knife insert may be triangular and mounted to expose one vertex to create a plurality of tooth/hook projections.

Abstract: An event can be analyzed for association with a security violation. Characters or other values of event data (e.g., command-line text) associated with the event can be provided sequentially to a trained representation mapping to determine respective representation vectors. Respective indicators can be determined by applying the vectors to a trained classifer. A token in the event data can be located based on the indicators. The event's can be determined to be associated with a security violation based on the token satisfying a token-security criterion. The representation mapping can be trained by adjusting model parameters so the trained representation predicts, based on a character of training command-line text, an immediately following character in the training command-line text. The classifier can be determined based on the trained representation mapping and classification training data indicating whether respective portions of training event data are associated with security violations.

Abstract: Event vectors can be determined for respective events based on respective command-line records and a trained representation mapping. Respective coordinate vectors can be determined, each having fewer elements than the respective event vector. Respective representations of at least some of the events can be presented via an electronic display at the respective coordinate vectors. A selection of a first representation can be received via a user interface. The events can be clustered based on the event vectors. A first cluster can be selected based on the selection. An indication of a tag can be received via the user interface. Each event of the first cluster can be associated with the tag. Some examples include transmitting a security command to cause a monitored computing device associated with an event in the first cluster to perform a mitigation action.

Abstract: An event can be associated with a monitored computing device and a command-line record. An event vector can be determined for each of a plurality of events based at least in part on at least a portion of the respective command-line record and on a trained representation mapping. A respective reduced event vector can be determined having fewer elements. The reduced event vectors can be clustered to determine cluster identifiers. A first event can be determined to be associated with a security violation based on a corresponding cluster identifier matching a cluster identifier of a second event that is associated with a security violation. In some examples, a cluster can include a relatively larger first group of events and a relatively smaller second group of events. That cluster can be determined to satisfy a criterion based on the numbers of events in at least one of the groups.

Abstract: The Totem Pole Solar Capture Housing is an improved design for a photo voltaic module enclosure. It is cylindrical in shape to capture the maximum amount of solar radiation on the housing's surface transferred to the module for conversion to electricity, and eliminates positional orientation. The cylindrical glass outer shell exposes one half of its circumference to solar radiation on contact. Used singly or in multiples interconnected together, one atop the other and erected vertically on a foot print. The inner photo voltaic module support core diameter and height can be sized to fit modules of different electrical outputs. The hollow center of the support core acts as the wiring channel to the base. Assembly couplings form the top and bottom of the enclosure and are critical in joining multiple enclosures into one vertical electrical output-enhanced assembly.

Abstract: The present invention provides various compositions, including compounds of Formula (I) or (Ia), or a species thereof, and pharmaceutically acceptable salts, solvates (e.g., hydrates), stereoisomer, tautomers, isotopic and other specified forms thereof. Also provided are methods (or uses) and kits involving the compounds or pharmaceutically acceptable compositions containing them for treating or preventing a disease (e.g., a proliferative disease such as cancer) in a subject. Administration of a compound or pharmaceutical composition described herein is expected to inhibit cyclin-dependent kinase 7 (CDK7), and thereby, induce apoptosis in tumor cells in the subject.