Patents by Inventor Michael A. Brennan
Michael A. Brennan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11934796Abstract: The systems and methods described herein can generate a voice-based interface to increase the accuracy of translations. The voice-based interface can result in fewer input audio signals being transmitted between devices of a network. A method includes: receiving a first input audio signal; generating, based on the first input audio signal, a first translation string in a second language and a second translation string in a first language; determining a first translation score based on a likelihood that the first input audio signal includes an utterance in the first language and a second translation score based on a likelihood that the first input audio signal includes an utterance in the second language; selecting the first translation string based on the first translation score and the second translation score; generating an output signal from the first translation string; and transmitting the output signal to the client device.Type: GrantFiled: June 13, 2022Date of Patent: March 19, 2024Assignee: GOOGLE LLCInventors: Michael Greenberg, Bertrand Damiba, Olivia Grace, Fei Wu, Shane Brennan
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Patent number: 11913902Abstract: A food wash reference fluid delivery apparatus includes a portable reference fluid reservoir comprising an inlet and an outlet and configured to store a reference fluid that includes a predetermined concentration of an analyte, a pump fluidly coupled to the outlet of the portable reference fluid reservoir and configured to pump the reference fluid from the outlet of the portable reference fluid reservoir, a sensor connector configured to fluidly couple with a sensor positioned along a fluid flow path of the food wash system, a sensor fluid line configured to provide the reference fluid from the pump to the sensor connector, an inlet fluid line configured to provide the reference fluid from the pump to the inlet of the portable reference fluid reservoir, and a valve configured to adjustably control a fluid flow rate of the reference fluid through the sensor fluid line and the inlet fluid line.Type: GrantFiled: November 9, 2020Date of Patent: February 27, 2024Assignee: SMARTWASH SOLUTIONS, LLCInventors: James M. Brennan, Eric Child Wilhelmsen, Danny Elmer Lindstrom, Christopher Michael McGinnis
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Patent number: 11890275Abstract: The present embodiments relate to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease. Particular compounds described herein exhibit selective inhibitory activity against CBP compared with BRD4.Type: GrantFiled: March 15, 2021Date of Patent: February 6, 2024Inventors: Lynnie Trzoss, Juan Manuel Betancort, Toufike Kanouni, Michael Brennan Wallace, Amogh Boloor
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Patent number: 11884648Abstract: The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for modulating the activity of histone demethylase enzymes. Additionally, the subject compounds and compositions are useful for the treatment of cancer or other neoplastic diseases, or maladies associated with abnormal histone demethylase activity. Accordingly, the substituted triazolylpyridine derivative compounds described herein are useful in methods and medicaments for treating cancer.Type: GrantFiled: November 13, 2020Date of Patent: January 30, 2024Assignee: Celgene Quanticel Research, Inc.Inventors: Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
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Publication number: 20230286917Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.Type: ApplicationFiled: March 24, 2023Publication date: September 14, 2023Applicant: CELGENE QUANTICEL RESEARCH, INC.Inventors: Young K. Chen, Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
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Publication number: 20230264970Abstract: Compositions comprise a perovskite and a non-perovskite. Perovskites comprise AxA?yA?(1?x?y)BX3, and non-perovskites may comprise A?, B and X, where A is a first cation, A? is a second cation, A? is a third cation, B is a fourth cation, X is an anion. In some instances, A, A?, and A? are each independently (NH2)2CH+, CH3NH3+, Cs+, Rb+, or (NH2)2(C?NH2)+, with the proviso that A, A?, and A? are each different. The perovskite may have a first crystal structure in which the anion is corner-sharing, the non-perovskite may have a second crystal structure comprising at least one of an orthorhombic structure, a hexagonal structure, or a perovskite-like structure, and 1?x?y may be greater than about 0.15.Type: ApplicationFiled: July 2, 2021Publication date: August 24, 2023Inventors: Masaru KUNO, Michael BRENNAN, Anthony RUTH, Ilia PAVLOVETC, Jeffrey A. CHRISTIANS, Taylor Hennessey MOOT, Joseph Matthew LUTHER
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Patent number: 11731954Abstract: The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds, and compositions (including pharmaceutical compositions) that include these compounds. The subject compounds and compositions are useful for inhibition of at least one histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer or neoplastic disease, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, retinoblastoma, or multiple endocrine neoplasia type 1.Type: GrantFiled: April 12, 2021Date of Patent: August 22, 2023Inventors: Young K. Chen, Michael Brennan Wallace
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Patent number: 11639333Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.Type: GrantFiled: December 23, 2013Date of Patent: May 2, 2023Assignee: CELGENE QUANTICEL RESEARCH, INCInventors: Young K. Chen, Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
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Publication number: 20230117519Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.Type: ApplicationFiled: November 3, 2022Publication date: April 20, 2023Applicant: CELGENE QUANTICEL RESEARCH, INC.Inventors: Amogh Boloor, Toufike Kanouni, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
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Patent number: 11535616Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.Type: GrantFiled: September 21, 2020Date of Patent: December 27, 2022Assignee: CELGENE QUANTICEL RESEARCH, INCInventors: Amogh Boloor, Toufike Kanouni, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
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Publication number: 20220298073Abstract: Described herein are cementitious compositions comprising biochar and methods of making such compositions. The compositions find use in a variety of applications, including use in a variety of building materials and building applications.Type: ApplicationFiled: March 18, 2022Publication date: September 22, 2022Inventors: Michael Brennan Pecha, Lori Elizabeth Tunstall, Julia Hylton
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Publication number: 20220029293Abstract: Various embodiments that pertain to a loop antenna are described. The loop antenna can be a single loop antenna that switches between a first phase and a second phase. While operating at different phases, the loop antenna can function at the same frequency. The loop antenna can observe a response to the frequency at the first phase and the frequency at the second phase. This can provide a wider range of information over operation in a single phase.Type: ApplicationFiled: October 7, 2021Publication date: January 27, 2022Inventors: Bing Mak, Adam Melber, Daniel Heinz, Michael Brennan
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Patent number: 11214542Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.Type: GrantFiled: September 18, 2020Date of Patent: January 4, 2022Assignee: CELGENE QUANTICEL RESEARCH, INC.Inventors: Young K. Chen, Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
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Patent number: 11145981Abstract: Various embodiments that pertain to a loop antenna are described. The loop antenna can be a single loop antenna that switches between a first phase and a second phase. While operating at different phases, the loop antenna can function at the same frequency. The loop antenna can observe a response to the frequency at the first phase and the frequency at the second phase. This can provide a wider range of information over operation in a single phase.Type: GrantFiled: October 30, 2018Date of Patent: October 12, 2021Assignee: The Government of the United States, as represented by the Secretary of the ArmyInventors: Bing Mak, Adam Melber, Daniel Heinz, Michael Brennan
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Publication number: 20210238161Abstract: The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds, and compositions (including pharmaceutical compositions) that include these compounds. The subject compounds and compositions are useful for inhibition of at least one histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer or neoplastic disease, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, retinoblastoma, or multiple endocrine neoplasia type 1.Type: ApplicationFiled: April 12, 2021Publication date: August 5, 2021Applicant: CELGENE QUANTICEL RESEARCH, INC.Inventors: Young K. Chen, Michael Brennan Wallace
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Publication number: 20210205284Abstract: The present embodiments relate to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease. Particular compounds described herein exhibit selective inhibitory activity against CBP compared with BRD4.Type: ApplicationFiled: March 15, 2021Publication date: July 8, 2021Applicant: CELGENE QUANTICEL RESEARCH, INC.Inventors: Lynnie TRZOSS, Juan Manuel BETANCORT, Toufike KANOUNI, Michael Brennan WALLACE, Amogh BOLOOR
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Patent number: 11020380Abstract: The present embodiments relate to substituted heterocyclic derivative therapeutic compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signalling, such as inflammatory disorders, cancer and neoplastic disease. Particular compounds described herein exhibit selective inhibitory activity against CBP compared with BRD4.Type: GrantFiled: January 27, 2020Date of Patent: June 1, 2021Assignee: CELGENE QUANTICEL RESEARCH, INC.Inventors: Lynnie Trzoss, Juan Manuel Betancort, Toufike Kanouni, Michael Brennan Wallace, Amogh Boloor
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Publication number: 20210139460Abstract: The present embodiments provide for substituted triazolylpyridine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for modulating the activity of histone demethylase enzymes. Additionally, the subject compounds and compositions are useful for the treatment of cancer or other neoplastic diseases, or maladies associated with abnormal histone demethylase activity. Accordingly, the substituted triazolylpyridine derivative compounds described herein are useful in methods and medicaments for treating cancer.Type: ApplicationFiled: November 13, 2020Publication date: May 13, 2021Applicant: CELGENE QUANTICEL RESEARCH, INC.Inventors: Zhe NIE, Jeffrey Alan Stafford, James Marvin Veal, Michael Brennan Wallace
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Patent number: 11001568Abstract: The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds, and compositions (including pharmaceutical compositions) that include these compounds. The subject compounds and compositions are useful for inhibition of at least one histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer or neoplastic disease, such as prostate cancer, breast cancer, bladder cancer, lung cancer, melanoma, retinoblastoma, or multiple endocrine neoplasia type 1.Type: GrantFiled: January 24, 2020Date of Patent: May 11, 2021Assignee: CELGENE QUANTICEL RESEARCH, INC.Inventors: Young K. Chen, Michael Brennan Wallace
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Publication number: 20210133597Abstract: In an approach to mapping marketing triggers across geographies, a computer receives one or more variables associated with one or more rulesets. A computer retrieves data corresponding to the one or more variables. A computer sorts the retrieved data by season. A computer computes a seasonal average for each variable by associated postal code. A computer trains a self-organizing map to arrange the data associated with the source geography postal codes into one or more source clusters. A computer maps the retrieved data and the computed data associated with the target geography to the one or more source clusters, thereby creating target counterpart clusters that correspond with at least one of the one or more source clusters. A computer applies one or more cluster rulesets associated with the one or more source clusters to the corresponding one or more target counterpart clusters. A computer outputs one or more bucket sheets.Type: ApplicationFiled: November 4, 2019Publication date: May 6, 2021Inventors: David Arthur Gold, Leonard G. Polhemus, JR., Robert Donald Hamilton, Declan Michael Brennan