Patents by Inventor Michael A. Brodney

Michael A. Brodney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF APOL1 AND METHODS OF USING SAME
    Publication number: 20230271945
    Abstract: The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).
    Type: Application
    Filed: February 7, 2023
    Publication date: August 31, 2023
    Inventors: Jingrong CAO, Jon H. COME, Leslie A. DAKIN, Francois DENIS, Warren A. DORSCH, Anne FORTIER, Martine HAMEL, Elaine B. KRUEGER, Brian LEDFORD, Suganthini S. NANTHAKUMAR, Olivier NICOLAS, Camil SAYEGH, Timothy J. SENTER, Tiansheng WANG, Michael BRODNEY, Kan-Nian HU, Peter ROSE, Kevin GAGNON, Yi SHI, Muna SHRESTHA, Ales MEDEK, Faith WITKOS
  • INHIBITORS OF APOL1 AND METHODS OF USING SAME
    Publication number: 20230203000
    Abstract: The disclosure provides at least one compound, tautomer, deuterated derivative, or pharmaceutically acceptable salt chosen from compounds of Formula I, tautomers thereof, deuterated derivatives of those compounds or tautomers, and pharmaceutically acceptable salts of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).
    Type: Application
    Filed: November 29, 2022
    Publication date: June 29, 2023
    Inventors: Leslie A. DAKIN, Michael A. BRODNEY, Kevin B. DANIEL, Elena DOLGIKH, Pedro M. GARCIA BARRANTES, Ales MEDEK, Jessica H. OLSEN, Timothy J. SENTER, Akira J. SHIMIZU, Steven D. STONE, Charlene TSAY
  • Inhibitors of APOL1 and methods of using same
    Patent number: 11618746
    Abstract: The disclosure provides a compound of Formula (I), including deuterated derivatives, pharmaceutically acceptable salts, and solvates thereof, solid state forms of those compounds, compositions comprising those compounds and solid forms, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: April 4, 2023
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jingrong Cao, Jon H. Come, Leslie A. Dakin, Francois Denis, Warren A. Dorsch, Anne Fortier, Martine Hamel, Elaine B. Krueger, Brian Ledford, Suganthini S. Nanthakumar, Olivier Nicolas, Camil Sayegh, Timothy J. Senter, Tiansheng Wang, Michael Brodney, Kan-Nian Hu, Peter Rose, Kevin Gagnon, Yi Shi, Muna Shrestha, Ales Medek, Faith Witkos
  • INHIBITORS OF APOL1 AND METHODS OF USING SAME
    Publication number: 20200377479
    Abstract: The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomeulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).
    Type: Application
    Filed: December 17, 2019
    Publication date: December 3, 2020
    Inventors: Jingrong CAO, Jon H. COME, Leslie A. DAKIN, Francois DENIS, Warren A. DORSCH, Anne FORTIER, Martine HAMEL, Elaine B. KRUEGER, Brian LEDFORD, Suganthini S. NANTHAKUMAR, Olivier NICOLAS, Camil SAYEGH, Timothy J. SENTER, Tiansheng WANG, Michael BRODNEY, Kan-Nian HU, Peter Rose, Kevin GAGNON, Yi SHI, Muna SHRESTHA, Ales MEDEK, Faith WITKOS
  • Novel Lactams as Beta Secretase Inhibitors
    Publication number: 20110224231
    Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment methods of synthesis, and intermediates are also disclosed.
    Type: Application
    Filed: November 12, 2009
    Publication date: September 15, 2011
    Applicant: Pfizer Inc.
    Inventors: Michael A. Brodney, Ivan V. Efremov, Christopher J. Helal, Brian T. O'Neill
  • Imidazole compounds for the treatment of neurodegenerative disorders
    Patent number: 7951958
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: May 31, 2011
    Assignee: Pfizer Inc.
    Inventors: Michael A. Brodney, Karen J. Coffman
  • Novel Class of Spiro Piperidines for the Treatment of Neurodegenerative Diseases
    Publication number: 20110046160
    Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
    Type: Application
    Filed: May 4, 2009
    Publication date: February 24, 2011
    Inventors: Michael A. Brodney, Christopher John Heldal, Brian Thomas O'neill
  • Pyrimidone Compounds As GSK-3 Inhibitors
    Publication number: 20100292205
    Abstract: The invention pertains to pyrimidone compounds that serve as effective GSK-3 inhibitors. The invention further relates to pharmaceutical compositions and methods comprising such pyrimidone compounds; and the use of such compounds for treating certain disorders.
    Type: Application
    Filed: August 13, 2007
    Publication date: November 18, 2010
    Applicant: PFIZER INC.
    Inventors: Bruce A. Lefker, Michael A. Brodney, Subas M. Sakya, Bruce A. Hay, Matthew D. Wessel, Edward L. Conn
  • Imidazole compounds for the treatment of neurodegenerative disorders
    Patent number: 7795447
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: January 9, 2008
    Date of Patent: September 14, 2010
    Assignee: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman
  • Imidazole compounds for the treatment of neurological disorders
    Patent number: 7781435
    Abstract: The present invention relates to compounds of Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: August 24, 2010
    Assignee: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman, Edward F. Kleinman, Brian T. O'Neill, Yuhpyng L. Chen
  • IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
    Publication number: 20100184737
    Abstract: The present invention relates to compounds of Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.
    Type: Application
    Filed: March 12, 2010
    Publication date: July 22, 2010
    Applicant: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman, Edward F. Kleinman, Brian T. O'Neill, Yuhpyng L. Chen
  • IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
    Publication number: 20100168107
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Application
    Filed: March 12, 2010
    Publication date: July 1, 2010
    Applicant: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman
  • BENZIMIDAZOLYL COMPOUNDS
    Publication number: 20080280933
    Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
    Type: Application
    Filed: July 20, 2007
    Publication date: November 13, 2008
    Inventors: Ivan Efremov, Bruce N. Rogers, Allen J. Duplantier, Lei Zhang, Qian Zhang, Noha S. Maklad, Edelweiss Evrard, Michael A. Brodney
  • IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
    Publication number: 20080227781
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Application
    Filed: January 9, 2008
    Publication date: September 18, 2008
    Inventors: Michael A. Brodney, Karen J. Coffman
  • Pyridyloxymethyl and benzisoxazole azabicyclic derivatives
    Patent number: 7345038
    Abstract: An aminomethylpyridyloxymethyl/benzisoxazole substituted azabicyclic compound of formula I, pharmaceutical composition comprising same, and a method of treating one or more CNS or other disorders, including concurrent treatment of disorders such as schizophrenia and depression, wherein formula I is or a pharmaceutically acceptable salt or thereof, wherein Z is wherein Y is methylene; X is oxygen; n is 0; R1 and R2 are each hydrogen or halogen; and R3 and R4 together with the nitrogen atom to which they are attached form i) a saturated non-aromatic 3 to 7 membered monocyclic ring, said ring i) being unsubstituted or substituted or substituted with one or more (C1–C4)alkyl, (C1–C4)alkoxy(C1–C4)alkyl, or hydroxy groups.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: March 18, 2008
    Assignee: Pfizer, Inc
    Inventors: Gene Michael Bright, Michael A. Brodney, Bishop Wlodecki
  • Sulfonamide compounds for the treatment of neurodegenerative disorders
    Patent number: 7345095
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, m, and n are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: March 18, 2008
    Assignee: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman
  • Imidazole compounds for the treatment of neurodegenerative disorders
    Patent number: 7342118
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: March 11, 2008
    Assignee: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman
  • SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
    Publication number: 20070129349
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, m, and n are as defined Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Application
    Filed: October 6, 2006
    Publication date: June 7, 2007
    Inventors: Michael Brodney, Karen Coffman
  • Imidazole compounds for the treatment of neurological disorders
    Publication number: 20070066613
    Abstract: The present invention relates to compounds of Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.
    Type: Application
    Filed: September 20, 2006
    Publication date: March 22, 2007
    Inventors: Michael Brodney, Karen Coffman, Edward Kleinman, Brian O'Neill, Yuhpyng Chen
  • Sulfonamide compounds for the treatment of neurodegenerative disorders
    Patent number: 7163942
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, m, and n are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating disorders and diseases, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: January 16, 2007
    Assignee: Pfizer Inc.
    Inventors: Michael A. Brodney, Karen J. Coffman