Abstract: The present invention provides AHR agonists, compositions thereof, and methods of using the same.

Abstract: The present invention provides AHR agonists, compositions thereof, and methods of using the same.

Abstract: A paint roller cleaning system including an elongated cylindrical member configured to receive a paint roller, a first-end-cap, and a second-end-cap. The first-end-cap for attachment at a first-end of the elongated cylindrical member and the second-end-cap for attachment at a second-end of the elongated cylindrical member. The first-end-cap includes a threaded-member and may couple to a water supply and direct water through a receiving-aperture. The second-end-cap includes an exit-aperture and a positioning-member for positioning the paint roller above the exit-aperture allowing for water to drain therethrough. The paint roller cleaning system may be used for cleaning a paint roller when inserted into the elongated cylindrical member and the water supply is activated.

Abstract: A backflow preventer including a body having an inlet for connection to an upstream portion of a plumbing system and an outlet for connection to a downstream portion of the plumbing system, a first check valve and a second check valve located in the body for preventing the reverse flow of water between the outlet and the inlet. An inlet pressure zone is positioned between the inlet and the first check valve, an outlet pressure zone is positioned between the outlet and the second check valve, and an intermediate pressure zone is positioned between the first and the second check valves. Position sensors sense the positions of the check valves, and pressure sensors sense the pressures in the zone. A controller in communication with the position sensors and the pressure sensors calculates the opening and closing pressures of the check valves.

Abstract: A backflow prevention assembly is configurable with varying lay-lengths and orientations. The assembly includes coupling assemblies and valve bodies that adjust in length and/or rotation to allow for the varying lay-lengths and orientations of the backflow prevention valves and assemblies with and without certification. A coupling assembly is connected to a backflow prevention valve and includes an outer sleeve and an inner sleeve that is slidingly received within the outer sleeve. The lay-length is adjusted by slidably moving the inner and outer sleeves with respect to one another.

Abstract: A shredding assembly for a grinder pump includes a stationary shredding ring mounted to an inlet of the pump, and a cutting device rotatable about an axial direction and fixed to a shaft of the pump. The shredding ring includes a top face, a bottom face, and a central opening extending from the top face to the bottom face and delimited in a radial direction by an inner periphery. Slots extending in the axial direction are formed in the inner periphery. The cutting device is positioned in the central opening of the shredding ring, and includes a front face and a back face. The front face includes a plurality of first cutting members extending in the axial direction and facing the slots. The back face includes a second cutting member projecting beyond the central opening with respect to the radial direction.

Abstract: A backflow prevention assembly is configurable with varying lay-lengths and orientations. The assembly includes coupling assemblies and valve bodies that adjust in length and/or rotation to allow for the varying lay-lengths and orientations of the backflow prevention valves and assemblies with and without certification. A coupling assembly is connected to a backflow prevention valve and includes an outer sleeve and an inner sleeve that is slidingly received within the outer sleeve. The lay-length is adjusted by slidably moving the inner and outer sleeves with respect to one another.

Abstract: The present invention relates to a stented valve, and can be used to repair and/or replace dysfunctional heart valves. In particular, the present invention relates to a stented valve that can be used to repair and/or replace a dysfunctional mitral or tricuspid heart valve. According to the present invention, there is provided a coupling for a stented valve and a fixation element, the coupling comprising: a connector adapted to receive the fixation element, and a guide adapted to receive the stented valve; wherein the connector is reciprocally movable relative to the guide.

Abstract: Various aspects of the present disclosure generally relate to wireless communication and testing. In some aspects, a device may receive information identifying a mount orientation of a wireless communication device, wherein the mount orientation indicates an orientation of a coordinate system of the wireless communication device relative to a coordinate system of a positioner. The device may capture measurement information at each position of a set of positions of the wireless communication device, wherein the set of positions comprises positions of the wireless communication device as the wireless communication device is rotated around an axis by the positioner, and wherein the measurement information is captured based at least in part on the mount orientation. The device may provide information identifying the measurement information. Some techniques and apparatuses described herein may use the measurement information to generate a codebook for beam generation. Numerous other aspects are provided.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a UE may communicate via a serving beam set of the UE, the serving beam set being one or more of a plurality of beams. The UE may measure another beam set in accordance with a measurement schedule configured to prioritize measurement on one or more adjacent beam sets associated with the serving beam set over one or more non-adjacent beam sets associated with the serving beam set. In some aspects, the one or more adjacent beam sets may be associated with one or more coverage areas that at least partially overlap a coverage area of the serving beam set, are adjacent to the coverage area of the serving beam set, or are associated with a measurement value that satisfies a threshold in the coverage area of the serving beam set. Numerous other aspects are provided.

Abstract: A backflow prevention assembly is configurable with varying lay-lengths and orientations. The assembly includes coupling assemblies and valve bodies that adjust in length and/or rotation to allow for the varying lay-lengths and orientations of the backflow prevention valves and assemblies with and without certification. A coupling assembly is connected to a backflow prevention valve and includes an outer sleeve and an inner sleeve that is slidingly received within the outer sleeve. The lay-length is adjusted by slidably moving the inner and outer sleeves with respect to one another.

Abstract: An embodiment of the present invention provides for a dry powder pharmaceutical composition suitable for dispersion in an aerosol for inhaled administration to a patient with cancer, the composition comprising: a cytidine analogue including salts, solvates, hydrates, and esters thereof; and a pharmaceutically acceptable excipient together forming the dry powder pharmaceutical composition suitable for dispersion in the aerosol for administration via inhalation to the patient with cancer. Another embodiment provides for a method of making the composition and a further embodiment provides for a method a treating a patient in need thereof with the composition.

Abstract: A wireless communication system includes a plurality of sensors and a device. Each sensor is configured to measure data and communicate over a network using low power signal communication. The device is connected to an in-wall power source and configured to wirelessly communicate over the network using low power signal communication. Further, the device is configured to transmit data from the sensors to a remote gateway using high power signal communication.

Abstract: A test cock for determining an operating condition of a backflow prevention system includes a body portion having a distal end and a proximal end and a space defined within the body portion. A distal opening is provided on the body portion at the distal end and a proximal opening is provided on the body portion at the proximal end and the proximal opening is in fluid connection with the body portion space. A body portion fitting is disposed in the body portion and is providing a fluid connection with the body portion space. A fluid sensor is coupled to the body portion fitting and is in fluid connection with the body portion space. A rotating system fitting has a first end and a second end where the second end is provided in the body portion proximal opening.

Abstract: The disclosure relates to storing a blockchain private key on a SIM device and securing the blockchain private key through multi-factor authentication. Various layers of security that controls access to the blockchain private key on the SIM device may be employed. These layers may include authentication of the user device on the cellular network using the SIM device, storage on a hidden partition of the SIM device that only a key applet executing on the SIM device or on a user device processor is aware of, storage of the blockchain private key in encrypted form, and/or use of the key applet to enforce credentialed access to the blockchain private key (e.g., the key applet obtains from the hidden partition and/or decrypts the blockchain private key only if a valid passcode is supplied to it).

Abstract: Disclosed herein is a novel method to fabricate magnetic silica nanomembranes using thin polymer cores based on silica deposition and self-wrinkling induced by thermal shrinkage. These micro- and nano-scale structures have vastly enlarged the specific area of silica, thus the magnetic silica nanomembranes can be used for solid phase extraction of nucleic acids. The magnetic silica nanomembranes are suitable for nucleic acid purification and isolation and demonstrated better performance than commercial particles in terms of nucleic acid recovery yield and integrity. In addition, the magnetic silica nanomembranes may have high nucleic acid capacity due to significantly enlarged specific surface area of silica. Methods of use and devices comprising the magnetic silica nanomembranes are also provided herein.

Abstract: An implantable biocompatible expander suitable for implantation into a urinary duct, comprises an elongated sinusoidal ring comprising at least two proximal prongs and at least two distal prongs, wherein the expander is resiliently deformable from a relaxed radially expanded orientation to a radially contracted orientation suitable for transluminal delivery through the urinary duct. The expander is configured to exert an outward radial force against a wall of the urinary duct when in-situ within the urinary duct. In particular, the expander is suitable for treatment of benign prostatic hyperplasia and configured for implantation into the prostatic urethra between, and substantially spanning the prostatic urethra between, the bladder neck and external sphincter.

Abstract: The present disclosure is directed to a method for purifying a sample containing nucleic acids to obtain isolated nucleic acids of a desired size range, either above a size cut-off, below a cut-off, or within a defined band of sizes, including: a) combining a nucleic acid-containing sample with a binding buffer to provide a binding mixture; b) contacting the binding mixture with a silica nanomembrane, wherein the silica nanomembrane adsorbs nucleic acids from the binding mixture within a desired size-range; and c) separating the bound nucleic acid from the remaining sample. Kits including a silica nanomembrane, a binding buffer and one or wash buffers are also provided herein.

Abstract: Disclosed herein is a novel method to fabricate magnetic silica nanomembranes using thin polymer cores based on silica deposition and self-wrinkling induced by thermal shrinkage. These micro- and nano-scale structures have vastly enlarged the specific area of silica, thus the magnetic silica nanomembranes can be used for solid phase extraction of nucleic acids. The magnetic silica nanomembranes are suitable for nucleic acid purification and isolation and demonstrated better performance than commercial particles in terms of nucleic acid recovery yield and integrity. In addition, the magnetic silica nanomembranes may have high nucleic acid capacity due to significantly enlarged specific surface area of silica. Methods of use and devices comprising the magnetic silica nanomembranes are also provided herein.

Abstract: A system for remotely measuring the characteristics of water passing through a plumbing control device (PCD) includes a sensor within the interior of the PCD. The sensor is configured to measure characteristics of the water to obtain measured data. The sensor is also linked to a microcontroller of the PCD. An antenna board is linked, and configured to transmit power, to both the microcontroller and the sensor. A mobile device is configured to locate the antenna board. The mobile device transmits power to the antenna board which, in turn, transmits power to the microcontroller and the sensor. When power is not being transmitted from the antenna board, the microcontroller and the sensor are powered off.