Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Methods and materials for modulating low light and/or shade tolerance, and red light specific responses in plants are disclosed. For example, nucleic acids encoding low light and/or SD+EODFR-tolerance polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased low light and/or SD+EODFR tolerance. In addition, methods and materials involved in increasing UV-B tolerance in plants and methods and materials involved in modulating biomass levels in plants are provided.

Abstract: Devices and techniques for status management in storage backed memory are disclosed herein. An encoded message can be received at a first interface of the memory package. Here, the memory package also includes a second interface to a host. The message can be decoded to obtain a decoded message that includes an attribute. The attribute can be compared a set of attributes that correspond to an advertised status of the memory package. The comparison enables a determination that the attribute is in the set of attributes. The advertised status of the memory package can then be modified in response to the determination that the attribute is in the set of attributes.

Abstract: Methods and materials for modulating low light and/or shade tolerance, and red light specific responses in plants are disclosed. For example, nucleic acids encoding low light and/or SD+EODFR-tolerance polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells. Also disclosed are plants having increased low light and/or SD+EODFR tolerance. In addition, methods and materials involved in increasing UV-B tolerance in plants and methods and materials involved in modulating biomass levels in plants are provided.

Abstract: An electric vehicle supply equipment (EVSE) charging station for charging a propulsion battery pack of an electric vehicle (EV) includes a charging cabinet, an electrical cable, and a charge coupler. The charging station is operable for providing a charging voltage or current to the battery pack during a charging operation. The electrical cable has a distal end connected to the charging cabinet. The charge coupler is connected to a proximal end of the electrical cable and connects to a charge receptacle of the EV. The charge coupler includes at least one heating element connected to the charge coupler. The heating element is configured to selectively heat the charge coupler in response to the environmental state being indicative of accumulated snow or ice on the charge coupler.

Abstract: An electric vehicle supply equipment (EVSE) charging station for charging a propulsion battery pack of an electric vehicle (EV) includes a charging cabinet, an electrical cable, a charge coupler, and a cradle operable for stowing the charge coupler. The charging station provides a charging voltage or current to the battery pack during a charging operation of the EV. The electrical cable has a distal end connected to the charging cabinet. The charge coupler is connected to a proximal end of the electrical cable and connects to a charge receptacle of the EV. The cradle includes at least one heating element connected thereto. The heating element is configured to selectively heat the cradle body in response to the environmental state of the cradle body being indicative of accumulated snow or ice on the charge coupler and/or the cradle body.

Abstract: The present disclosure relates generally to a “clocking” mechanism that give customers the flexibility to adjust light output distribution of luminaires to a desired level. The “clocking” mechanism gives the flexibility to adjust a position of a retainer ring of a LED system with respect to a mounting module that includes a heat sink adapter housing.

Abstract: A machine for packaging multiple containers wherein a flexible carrier stock is fed across a jaw drum. A plurality of containers are moved through the machine whereby the carrier is subsequently positioned over the plurality of containers so that flexible carrier stock engages with two or more of the containers to form a package. The jaw drum and other operative components of the machine are preferably vertically adjustable to accommodate a range of container sizes and carrier configurations.

Abstract: In one embodiment, a system for digitally providing access to an article is disclosed. The system includes a locking unit to secure and article in a locked state and a server. The server generates a digital key associated with the article or the locking unit. When the digital key is provided to a portable electronic device of a user, the digital key enables the portable electronic device to alter the locking unit between the locked state and the unlocked state without the user paying for the article or authorizing payment for the article. Upon a first event, the digital key is assigned to the user and provided to the portable electronic device of the user. The first event includes the user initiating a request for access to the article or the digital key, and verification that the user satisfies a predetermined condition.

Abstract: A retail security system that includes a locking system having locking assemblies that can be locked and unlocked directly by a consumer or clerk/employee using his or her mobile phone or other portable electronic device. Each of the locking assemblies may be configured to lock an article so that it cannot be freely accessed. The security system may include a sanitizing system that sanitizes the article after a consumer returns the article to the locking system without making a purchase. The security system may include a computer apparatus that allows an owner of the security system to access a software application that provides the owner with information/data about access to the locked articles.

Abstract: The present invention is directed to a system, method, and apparatus for managing a packaging article secured via a locking unit alterable between a locked state and an unlocked state. An indication that a user desires to handle the article may be received and an authorization of the user to handle the article may be performed. An actuator may cause the locking unit to alter from the locked state to the unlocked state, for example, based on the user being authorized to handle the article. Based on the user desiring to purchase the article, inventory information of the article may be updated by decreasing the number of articles in inventory by the article purchased. An account of the user may be charged a cost of the article. An indication may be provided to the user that the article has been purchased.

Abstract: A retail security system that includes a locking system having locking assemblies that can be locked and unlocked directly by a consumer or clerk/employee using his or her mobile phone or other portable electronic device. Each of the locking assemblies may be configured to lock an article so that it cannot be freely accessed. The security system may include a sanitizing system that sanitizes the article after a consumer returns the article to the locking system without making a purchase. The security system may include a computer apparatus that allows an owner of the security system to access a software application that provides the owner with information/data about access to the locked articles.

Abstract: Compositions and methods for multiplex delivery and gene editing in vitro are provided.

Abstract: A machine for packaging multiple containers wherein a flexible carrier stock is fed across a jaw drum. A plurality of containers are moved through the machine whereby the carrier is subsequently positioned over the plurality of containers so that flexible carrier stock engages with two or more of the containers to form a package. The jaw drum and other operative components of the machine are preferably vertically adjustable to accommodate a range of container sizes and carrier configurations.

Abstract: Devices and techniques for status management in storage backed memory are disclosed herein. An encoded message can be received at a first interface of the memory package. Here, the memory package also includes a second interface to a host. The message can be decoded to obtain a decoded message that includes an attribute. The attribute can be compared a set of attributes that correspond to an advertised status of the memory package. The comparison enables a determination that the attribute is in the set of attributes. The advertised status of the memory package can then be modified in response to the determination that the attribute is in the set of attributes.

Abstract: A retail security system that includes a locking system having locking assemblies that can be locked and unlocked directly by a consumer or clerk/employee using his or her mobile phone or other portable electronic device. Each of the locking assemblies may be configured to lock an article so that it cannot be freely accessed. The security system may include a sanitizing system that sanitizes the article after a consumer returns the article to the locking system without making a purchase. The security system may include a computer apparatus that allows an owner of the security system to access a software application that provides the owner with information/data about access to the locked articles.

Abstract: Provided is a system to generate a machine learning model to provide a predicted cost associated with shipping a shipment of freight from an origin of the shipment of freight to a destination of the shipment of freight based on a training dataset and a predicted distance and to determine the predicted cost associated with shipping a specified shipment of freight from the origin of the specified shipment of freight to the destination of the specified shipment of freight using the machine learning model. The training dataset includes data associated with shipments of freight conducted during a first time interval and data associated with shipments of freight conducted during a second time interval. The first time interval is at least a year and the second time interval is shorter than the first time interval. A computer implemented method and computer program product are also provided.

Abstract: Devices and techniques for status management in storage backed memory are disclosed herein. An encoded message can be received at a first interface of the memory package. Here, the memory package also includes a second interface to a host. The message can be decoded to obtain a decoded message that includes an attribute. The attribute can be compared a set of attributes that correspond to an advertised status of the memory package. The comparison enables a determination that the attribute is in the set of attributes. The advertised status of the memory package can then be modified in response to the determination that the attribute is in the set of attributes.

Abstract: The present disclosure relates generally to a “clocking” mechanism that give customers the flexibility to adjust light output distribution of luminaires to a desired level. The “clocking” mechanism gives the flexibility to adjust a position of a retainer ring of a LED system with respect to a mounting module that includes a heat sink adapter housing.