Abstract: Genetically modified mice characterized by one or more symptoms or signs associated with expression of human APOE4p and mouse Trem2p and relevant to non-familial late-onset Alzheimer's disease are provided wherein the genome of the mouse includes: 1) a DNA sequence encoding a human APOE4 protein (APOE4p) operably linked to a promoter; and 2) a DNA sequence encoding a mouse Trem2 protein having a mutation p,R47H (Trem2p) operably linked to a promoter, such that the mouse expresses human APOE4p and mouse Trem2p. Methods ace provided for screening for a compound for use in the treatment of Alzheimer's disease using such genetically modified mice.

Abstract: A method of building a new voice having a new timbre using a timbre vector space includes receiving timbre data filtered using a temporal receptive field. The timbre data is mapped in the timbre vector space. The timbre data is related to a plurality of different voices. Each of the plurality of different voices has respective timbre data in the timbre vector space. The method builds the new timbre using the timbre data of the plurality of different voices using a machine learning system.

Abstract: A chute rotation control system for a snow thrower is disclosed. One example embodiment is a chute rotation control system configured to rotate a chute of a snow thrower, comprising: a chute rotation motor coupled to the chute via one or more gears, wherein the chute rotation motor is configured to alternately rotate the chute clockwise and counterclockwise; a left chute control configured to receive one or more left user inputs and to generate a left output signal; a right chute control configured to receive one or more right user inputs and to generate a right output signal; and a motor controller configured to receive the left input signal and the right input signal, to cause the chute rotation motor to rotate the chute counterclockwise in response to the left input, and to cause the chute rotation motor to rotate the chute clockwise in response to the right input signal.

Abstract: A method secures hash chains via hybrid consensus. A proximate payload for a proximate chain block for a proximate chain is obtained. A first identifier of the proximate chain and the proximate payload are hashed with a hash function to generate a second identifier of the proximate chain. The proximate chain block is added to the proximate chain. The proximate chain block includes the first identifier, the second identifier, and the proximate payload. A request to add the second identifier to a reporting chain is transmitted. A response indicating that the second identifier is incorporated into the reporting chain using the consensus mechanism is received.

Abstract: A method for using shareable and nested transaction on hash chains includes storing transaction data of a transaction of a hash chain. A lock block is appended to the hash chain. Appending the lock block includes setting a tail block identifier of the hash chain from a preceding tail block of a preceding transaction to the lock block. A data block is appended to the hash chain. Appending the data block includes setting the tail block identifier of the hash chain to the data block. The method further includes removing the transaction data from the transaction without invalidating the hash chain. The method further includes appending an updated data block to the hash chain to update the transaction with updated transaction data.

Abstract: A projectile designed to be lead-free and have a ballistic coefficient ranging from about 0.13 to about 0.80 or greater for enhanced energy/performance at extended ranges may have an elongated body formed with a jacket including a wall having an end defining an ogive portion and a cavity or recess defined within the jacket and in which a core is received. The projectile can be configured in various calibers and sizes. The projectile core may be formed from a plurality of core sections, and at least one of the plurality of core sections may include tungsten powder and a lead-free binder material pressed together to form a substantially cylindrical shape or compact. One or more of the core sections further can be sintered, and the one or more core sections may be received in an end-to-end relationship within the cavity defined by the jacket to form a stacked, sectional core.

Abstract: A method of implementing administrative services for a compensation platform is disclosed. One or more interactive compensation representation views are generated based on an evaluation of mapping rules against a flexible ontology and current data state, the flexible ontology comprising customizable compensation components, relationships, and properties. One or more compensation representation views are dynamically updated in real-time in response to changes in compensation data, user context, or access permissions without requiring manual regeneration of the one or more compensation representations. The one or more interactive compensation representation views include a user interface element displayed in response to a user selection of compensation data, wherein the user interface element provides direct access to compensation information relevant to the selected compensation data without requiring a change to another screen or another user context.

Abstract: A portfolio completion (PC) computing device is disclosed. The PC computing device is configured to: (1) retrieve, from a memory device, historical financial data, historical value parameters data, and historical portfolio data associated with a plurality of customers, (2) train a PC model relating the historical financial data to the historical portfolio data and the historical value parameters data, wherein the PC model predicts a customized portfolio based upon user financial data and user value parameters data, (3) store the trained PC model in the memory device, (4) receive customer financial data and customer value parameter data associated with a customer, and (5) predict a customized allocation portfolio for the customer using the trained PC model based upon the received customer financial data and customer value parameter data.

Abstract: Systems and methods are provided for automatically marking locations within a radiograph of one or more dental pathologies, anatomies, anomalies or other conditions determined by automated image analysis of the radiograph by a number of different machine learning models. Image annotation data may be generated based at least in part on obtained results associated with output of the multiple machine learning models, where the image annotation data indicates at least one location in the radiograph and an associated dental pathology, restoration, anatomy or anomaly detected at the at least one location by at least one of the machine learning models. A number of different pathologies may be identified and their locations marked within a single radiograph image.

Abstract: An apparatus, including an electrode, wherein the electrode is at least one of directly or indirectly fixed to an otic capsule or tissue associated with the otic capsule of a human at least in part with cured securement material, wherein the electrode is part of a human ailment treatment and/or mitigation system, at least in part implantable in the human.

Abstract: A neural stimulator, suitable for implanting in a recipient, and having a flying lead with a configurable electrode. A benefit is an intra-operative ability to adjust the connection between the lead and an anatomically correct electrode, which obviates the need to manufacture multiple different configurations of implant to suit different placements of flying lead electrode.

Abstract: A method includes receiving information regarding a position and/or an orientation of an implantable device relative to a body portion of a recipient during and/or after implantation of at least a portion of the device on and/or into the body portion. The device includes a plurality of electrodes configured to apply electroporation to first cells of the body portion while not damaging second cells of the body portion. The method includes estimating, in response at least in part to the information, first interactions of the electrodes with respect to the first cells. The method further includes estimating, in response at least in part to the information, second interactions of the electrodes with respect to the second cells.

Abstract: A method includes providing an electrode configured to be implanted within a body portion of a recipient in tissue at a target implantation location, the electrode comprising a screw portion. The method further includes driving the screw portion into the tissue at the target implantation location, monitoring at least one signal indicative of insertion of the screw portion into the tissue, and stopping the driving in response to the at least one signal being indicative of a predetermined insertion of the screw portion.

Abstract: An external portion of an auditory prosthesis includes an external magnet that interacts with an implantable magnet to hold the external portion against the skin. Magnetic force generated by the stray field of these magnets can disturb the operation of a vibrating element of the auditory prosthesis. The technologies described herein utilize additional magnets disposed within portions of the auditory prosthesis to redirect the magnetic flux, which allows the vibrating element to be disposed more closely to the magnets, reducing the overall height profile of the prosthesis.

Abstract: An external portion of an auditory prosthesis includes an external magnet that interacts with an implantable magnet to hold the external portion against the skin. Magnetic force generated by the stray field of these magnets can disturb the operation of a vibrating element of the auditory prosthesis. The technologies described herein utilize additional magnets disposed within portions of the auditory prosthesis to redirect the magnetic flux, which allows the vibrating element to be disposed more closely to the magnets, reducing the overall height profile of the prosthesis.

Abstract: Presented herein is an electroporation shield configured to be removably coupled to an implantable stimulating assembly that includes one or more stimulation electrodes. The electroporation shield is coupled to stimulating assembly such that the electroporation shield electrically insulates the one or more of the stimulation electrodes from an electroporation electrical field generated by one or more electroporation electrodes coupled to the electroporation shield. The electroporation shield may be coupled to the stimulating assembly in a manner that facilitates removal of the electroporation shield and the one or more electroporation electrodes. After electroporation, without having to remove or reinsert the stimulating assembly, thereby exposing the one or more stimulation electrodes to the cells of the recipient for subsequent delivery of stimulation.

Abstract: Presented herein are techniques for assessing one or more outcomes associated with implantation of one or more electrodes into the inner ear of a recipient.

Abstract: Methods and systems are disclosed for scheduling a task of a user based on a cyber-physical-social (CPS) context of activities. The present disclosure is directed to increasing the efficiency of performing tasks by grouping tasks with the same or similar task CPS contexts so that they are performed in conjunction with one another. A stream of user activities is received that encompasses the CPS context, tasks are identified and classified based on a CPS context model. The CPS model is trained using CPS context and annotations for identified tasks as input to create classes of tasks. The classes of tasks from the model are used to group similar tasks. The present disclosure enables users to receive recommendations on clustering tasks with the same or similar contexts based on an online tool, a location, and collaborators to be performed together to improve productivity.

Abstract: There is provided a phospholipid composition which is a bilayer or micelle comprising at least one embedded protein-polymer surfactant conjugate comprising an anchor protein, wherein the anchor protein is a cationised protein or an anionised protein, the composition characterised in that the anchor protein is: a) an active enzyme; or b) is a protein which does not comprise a —CH2C(O)NCH3(CH2)3NCH3)2H+ linker covalently bonded to an amino acid side chain.

Abstract: A composite material for use in water treatment. The composite material includes a porous matrix including a resin capable of retaining a catalyst and magnetic material therein, and includes a density regulating portion disposed therein. The catalyst is capable of facilitating a chemical reaction involving a contaminants in the water. The magnetic material and density regulating portion can be used to separate the composite material from treated water. Systems and methods of use involving passive water treatment, continuous water treatment, solar light exposure, UV light exposure, and electrochemical cells, employing photochemical, electrochemical, and photoelectrochemical reactions are described. Methods of manufacture are described.