Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: Small, low-cost satellite systems, like CubeSats or other microsatellites, can exhibit reduced reliability relative to higher-cost satellite systems. This can result in difficulty identifying, communicating with, and tracking such satellite systems when they fail. Provided herein are reliable, low-cost, low-energy, turn-key systems for identification and tracking of small satellites that can be readily added to a microsatellite with minimal integration costs and while occupying a minimal amount of volume, mass, and external area of the host satellite. These systems are electrically isolated from the satellite bus, being powered by internal batteries or other separate energy sources and providing reliable identification and tracking even when the other systems of the satellite have failed.

Abstract: Small, low-cost satellite systems, like CubeSats or other microsatellites, can exhibit reduced reliability relative to higher-cost satellite systems. This can result in difficulty identifying, communicating with, and tracking such satellite systems when they fail. Provided herein are reliable, low-cost, low-energy, turn-key systems for identification and tracking of small satellites that can be readily added to a microsatellite with minimal integration costs and while occupying a minimal amount of volume, mass, and external area of the host satellite. These systems are electrically isolated from the satellite bus, being powered by internal batteries or other separate energy sources and providing reliable identification and tracking even when the other systems of the satellite have failed.

Abstract: A system and a method of managing endoscope data are disclosed. The system receives information corresponding to endoscopes in storage, the endoscopes in usage, the endoscopes undergoing the reprocessing operation, and the endoscopes that are undergoing repair in a facility. The system captures each step in storing, usage, reprocessing, and repairing along with the identification of authorized users performing the steps. The system further captures updates made by the users upon storing, usage, reprocessing, and repairing in real-time and updates the information accordingly. The system reduces manual documentation of recording endoscopes inventory and determines how many endoscopes are currently available for operation, how many endoscopes are lying in storage, and how many endoscopes are undergoing repair or reprocessing or cleaning in real-time. Further, the system provides accountability of technicians on each step to properly document uniform and complete safety protocols.

Abstract: A scalable image viewing architecture that minimizes requirements placed upon a server in a distributed architecture. Image data is pushed to a cloud-based service and pre-processed such that the image data is optimized for viewing by a remote client computing device. The associated metadata is separated and stored, and made available for searching. 2D image data may be communicated and rendered by the remote client computing device; whereas 3D image data be rendered by the cloud-based service by imaging servers and communicated to client computing device.

Abstract: An event management system is provided. The event management system comprises at least one wearable device that includes a wearable support structure, a display coupled to the support structure, a plurality of sensors coupled to the support structure, a controller removably coupled to the display, the plurality of sensors, and the support structure, the controller including one or more processors coupled to a memory and one or more antennas, and a user manager component executable by the one or more processors of the controller and configured to create anonymous biometric information descriptive of at least one user wearing the at least one wearable device based at least in part on information received from the plurality of sensors and transmit at least one portion of the anonymous biometric information.

Abstract: A decorative lighting system designed for both residential and commercial use is provided, which offers homeowners and business owners a means by which to selectively decorate their homes and businesses in a year-round fashion. Users can install the decorative lighting either a single time or few times, and thereafter manipulate a plurality of predetermined color schemes using a pre-programmed control panel. A plurality of methods and means for controlling the programming are also disclosed.

Abstract: Inhibitors of syndapin I binding to dynamin I (DynI) are provided. Examples include mimetics of a region of DynI including the serine residues S774 and S778 or phosphorylatable amino acids in homologous positions. Typically, the mimetics exclude or do not imitate at least one phosphorylation site provided by the serine residues or phosphorylatable amino acids. Peptide fragment inhibitors comprising or consisting of this region of DynI are also described. The inhibitors have application in the prophylaxis or treatment of neurological diseases or conditions. The inhibitors can also be used to inhibit neuronal cell vesicle trafficking and synaptic signal transmission.

Abstract: A remote timer, thermometer and paging system includes a first unit having a radio frequency transmitter, a housing having a recess formed therein and a timer for selecting a time period. The system includes a temperature sensor in communication with the first unit for measuring temperature. The system also includes a second unit having a radio frequency receiver adapted to communicate with the radio frequency transmitter of the first unit. The first unit is adapted to wirelessly transmit an alert signal to the second unit when the temperature measured by the temperature sensor matches a pre-selected temperature or when the selected time period has expired. The second unit is insertible into the recess for storage inside the first unit and is removable from the first unit for moving the second unit to a remote location away from the first unit.

Abstract: Amine-aldehyde resins are disclosed for removing a wide variety of solids and/or ionic species from the liquids in which they are suspended and/or dissolved. These resins are especially useful as froth flotation depressants, for example in the beneficiation of value materials (e.g., bitumen, coal, or kaolin clay) to remove impurities such as sand. The resins are also useful for treating aqueous liquid suspensions to remove solid particulates, as well as for removing metallic ions in the purification of water.

Abstract: Modified resins are disclosed for removing a wide variety of solids and/or ionic species from the liquids in which they are suspended and/or dissolved. These modified resins are especially useful as froth flotation depressants in the beneficiation of many types of materials (e.g., mineral and metal ores), including the beneficiation of impure coal comprising clay impurities, as well as in the separation of valuable bitumen from solid contaminants such as sand. The modified resins are also useful for treating aqueous liquid suspensions to facilitate the removal of solid particulates, as well as the removal of metallic ions in the purification of water. The modified resins comprise a base resin that is modified with a coupling agent, which is highly selective for binding to solid contaminants and especially siliceous materials such as sand or clay.

Abstract: A remote timer, thermometer and paging system includes a first unit having a radio frequency transmitter, a housing having a recess formed therein and a timer for selecting a time period. The system includes a temperature sensor in communication with the first unit for measuring temperature. The system also includes a second unit having a radio frequency receiver adapted to communicate with the radio frequency transmitter of the first unit. The first unit is adapted to wirelessly transmit an alert signal to the second unit when the temperature measured by the temperature sensor matches a pre-selected temperature or when the selected time period has expired. The second unit is insertible into the recess for storage inside the first unit and is removable from the first unit for moving the second unit to a remote location away from the first unit.

Abstract: Amine-aldehyde resins are disclosed for removing a wide variety of solids and/or ionic species from the liquids in which they are suspended and/or dissolved. These resins are especially useful as froth flotation depressants, for example in the beneficiation of value materials (e.g., bitumen, coal, or kaolin clay) to remove impurities such as sand. The resins are also useful for treating aqueous liquid suspensions to remove solid particulates, as well as for removing metallic ions in the purification of water.

Abstract: Modified resins are disclosed for removing a wide variety of solids and/or ionic species from the liquids in which they are suspended and/or dissolved. These modified resins are especially useful as froth flotation depressants in the beneficiation of many types of materials (e.g., mineral and metal ores), including the beneficiation of impure coal comprising clay impurities, as well as in the separation of valuable bitumen from solid contaminants such as sand. The modified resins are also useful for treating aqueous liquid suspensions to facilitate the removal of solid particulates, as well as the removal of metallic ions in the purification of water. The modified resins comprise a base resin that is modified with a coupling agent, which is highly selective for binding to solid contaminants and especially siliceous materials such as sand or clay.

Abstract: The present invention relates to an assay for detecting membrane fusion. More particularly the present invention relates to assays for detecting exocytosis and/or endocytosis wherein membrane fusion is detected by an increase in fluorescence of a lipophilic fluorescent dye due to fluorescence resonance energy transfer (FRET) occurring from one lipophilic fluorescent dye to another lipophilic fluorescent dye.