Abstract: Disclosed herein are systems and methods for tracking and managing location information for automobile assets. By affixing passive transmitter tags with unique identification information to automobile assets, location information may be associated with designated areas and/or location information by scanning the passive transmitter tags at various scan points. The location and automobile asset information may be stored, read, and updated in a centralized cloud database platform, accessible at varying levels to suppliers, manufacturers, shippers, and others.

Abstract: Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.

Abstract: Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.

Abstract: Provided herein are methods of treating patients with a combination of a transcription inhibitor (e.g., a STAT3 inhibitor) and an immune checkpoint blockade therapy (e.g., anti-PD-1 therapy, anti-PD-L1 therapy, anti-CTLA-4 therapy). The patient may have a proliferative disease, such as cancer or psoriasis. The patient may have a pathogenic infection.

Abstract: A system that utilizes two different types of RFID data capture devices; at least one standard fixed RFID portal (e.g., one reader and two antennas) and at least one handheld or mobile RFID device in combination with passive RFID tags (i.e., transmitters). The system acquires, tracks, and reports asset location specific to a manufacturing plant and storage yard (i.e., the inventory), as well as production milestone events. GPS asset location data is tracked almost continuously and reported on demand.

Abstract: Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.

Abstract: The present disclosure is directed to dual specificity antibodies which may bind to PD-L1 or PD-L2 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1 or PD-L2.

Abstract: The present disclosure is directed to antibodies binding to PD-L1 and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1.

Abstract: The present disclosure is directed to bispecific antibodies which bind to both PD-L1 and PD-L2, and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1, PD-L2, or both.

Abstract: Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.

Abstract: Spirally wound electric double layer capacitor devices are generally disclosed. In some embodiments, the spirally wound electric double layer capacitor device is configured so that fluid being treated flows in an axial direction through the device.

Abstract: This invention describes a capacitor that formed by a charge or species specific membrane material filled with aqueous or non-aqueous liquid with soluble salts dissolved and non-dissolved in solution and contained within the membrane material. When charged, the oppositely charged ion will leave the structure, leaving behind a charged atomic capacitor.

Abstract: Spirally wound electric double layer capacitor devices are generally disclosed. In some embodiments, the spirally wound electric double layer capacitor device is configured so that fluid being treated flows in an axial direction through the device.

Abstract: Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.

Abstract: This invention describes a capacitor that formed by a charge or species specific membrane material filled with aqueous or non-aqueous liquid with soluble salts dissolved and non-dissolved in solution and contained within the membrane material. When charged, the oppositely charged ion will leave the structure, leaving behind a charged atomic capacitor.

Abstract: This invention relates to an electric double layer capacitor electrochemical cylinder (11) made up of concentric layers of capacitors (16), current collectors (14a, 14b, 14c), ion specific membranes (18, 18a, 18b) and dielectric spacer (20) wrapped around an inner support tube (12) that can be used as a high capacitance capacitor and to remove dissolved solids from a liquid stream such as water, acid, aqueous or non-aqueous.

Abstract: Disclosed herein are systems and methods for tracking and managing location information for automobile assets. By affixing passive transmitter tags with unique identification information to automobile assets, location information may be associated with designated areas and/or location information by scanning the passive transmitter tags at various scan points. The location and automobile asset information may be stored, read, and updated in a centralized cloud database platform, accessible at varying levels to suppliers, manufacturers, shippers, and others.

Abstract: A system that utilizes two different types of RFID data capture devices; at least one standard fixed RFID portal (e.g., one reader and two antennas) and at least one handheld or mobile RFID device in combination with passive RFID tags (i.e., transmitters). The system acquires, tracks, and reports asset location specific to a manufacturing plant and storage yard (i.e., the inventory), as well as production milestone events. GPS asset location data is tracked almost continuously and reported on demand.

Abstract: Miniature capacitive deionization devices and related systems and methods are generally described. The devices may be incorporated as part of a water treatment and process system. Humidifier systems comprising a humidifier unit and a capacitive deionization device fluidically coupled with the humidifier unit are also disclosed. For example, the miniature capacitive deionization devices may be incorporated into a point of use humidifier.