Patents by Inventor Michael A. David

Michael A. David has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PKM2 modulators and methods for their use
    Patent number: 10207996
    Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: February 19, 2019
    Assignee: Tolero Pharmaceuticals, Inc.
    Inventors: Koc-Kan Ho, Yong Xu, Michael David Saunders, Xiaohui Liu, Scott Albert Pearce, Kevin Bret Wright, Jason Marc Foulks, Kenneth Mark Parnell, Steven Brian Kanner, David Lee Vollmer, Jihua Liu
  • Rotary Platforms
    Publication number: 20190045736
    Abstract: A rotary dairy cow milking platform that rotates about a rotational axis and has a plurality of pre-fabricated moulded bail floor defining modular components 1-10 and a supporting substructure 12, 13 14. Each modular component is detachable from the substructure and has been pre-formed independently of any components from the substructure. Each modular component is also totally or at least in part formed from a fibre reinforced resin based composite material. The modular components each have a mould defined rigid exoskeleton 34 wrapped about an inlay or an imbedded core 33 of another material moulded within the exoskeleton. The end peripheries of the modular components are substantially radially aligned with respect to the axis of rotation of the milking platform. Further, the modular components have been assembled onto the substructure to form a substantially annular deck of the milking platform.
    Type: Application
    Filed: October 16, 2018
    Publication date: February 14, 2019
    Inventors: Joshua Wayne Janmaat, Michael David Bates
  • SPIRO-CONDENSED PYRROLIDINE DERIVATIVES AS DEUBIQUITYLATING ENZYMES (DUB) INHIBITORS
    Publication number: 20190048008
    Abstract: The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of Cezanne 1. The invention further relates to the use of DUB inhibitors in the treatment of cancer.
    Type: Application
    Filed: March 2, 2017
    Publication date: February 14, 2019
    Inventors: Mark Ian KEMP, Martin Lee STOCKLEY, Michael David WOODROW, Alison JONES
  • Kitty door knocker
    Publication number: 20190048653
    Abstract: A door knocker for use by a cat for requesting entry into a house. This knocker comprises a mounting block attached to a door surface; a longitudinal spring having a first end mounted to the mounting block and a second end extending vertically downward from the first end. A hardwood ball is mounted to the second end. The ball is held at a knocking distance from the door surface. A string with loose frayed ends is attached to the second end of the spring near the ball. A cat coming near the door knocker is attracted to the string with frayed ends and instinctively starts to play with the string to operate the door knocker into a series of repetitive door knocks. The door knocker according to the present invention does not require any significant physical or mental effort from a cat.
    Type: Application
    Filed: August 10, 2017
    Publication date: February 14, 2019
    Inventor: Michael David Langstroth
  • Airfoil with improved coating system
    Patent number: 10202855
    Abstract: A coating system for a surface of a superalloy component is provided. The coating system includes a MCrAlY coating on the surface of the superalloy component, where M is Ni, Fe, Co, or a combination thereof. The MCrAlY coating generally has a higher chromium content than the superalloy component. The MCrAlY coating also includes a platinum-group metal aluminide diffusion layer. The MCrAlY coating includes Re, Ta, or a mixture thereof. Methods are also provided for forming a coating system on a surface of a superalloy component.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: February 12, 2019
    Assignee: General Electric Company
    Inventors: Bangalore Aswatha Nagaraj, Michael David Clark, Susan Lee Sheets
  • VESSEL CAP
    Publication number: 20190039785
    Abstract: A vessel cap (100, 10) for exchanging gas in and pressuring a vessel headspace (30), the cap (100, 10) comprising a cap inlet (11), a seal (12) arranged to form a gas-tight seal on a vessel opening, a pressure reducing valve, a gas inlet port (25) arranged to allow incoming gas into the vessel headspace (30), a gas outlet port (31) arranged to allow outgoing gas to escape from the vessel headspace (30).
    Type: Application
    Filed: January 26, 2017
    Publication date: February 7, 2019
    Applicant: GOBUBL LIMITED
    Inventor: MICHAEL DAVID GORMLEY
  • METHODS OF ASSESSING AND TREATING CANCER IN SUBJECTS HAVING DYSREGULATED LYMPHATIC SYSTEMS
    Publication number: 20190040139
    Abstract: Provided herein is a method for determining cancer treatment using an immune modulating therapy in a subject in need thereof. The method comprises assessing whether a lymphatic system in a subject is dysregulated. When the lymphatic system is dysregulated, a treatment for the lymphatic system is determined before a therapeutic amount of an immune modulating therapy is administered to treat cancer in the subject. Alternatively, when the lymphatic system is dysregulated, an immune modulating therapy is selected to treat cancer in the subject, which immune modulating therapy is independent of immune-cell priming, antigen trafficking, antigen presentation, and any combination thereof. The subject may also be treated for cancer accordingly.
    Type: Application
    Filed: October 9, 2018
    Publication date: February 7, 2019
    Inventors: Michael David KUO, Ching-Yu HUANG
  • THERMAL MANAGEMENT OF INTEGRATED CIRCUITS
    Publication number: 20190043737
    Abstract: A system includes a programmable logic device (PLD) and a processor. The processor determines sets of power values associated with respective portions of a plurality of portions of the PLD. The processor also determines a temperature value for each portion of the plurality of portions based on the sets of power values and platform data associated with the PLD. Additionally, the processor generates a power map indicative of an expected amount of power for each portion of the plurality of portions based on the sets of power values. Furthermore, the processor generates a heat map indicative of an expected temperature value for each portion of the plurality of portions.
    Type: Application
    Filed: January 12, 2018
    Publication date: February 7, 2019
    Inventor: Michael David Hutton
  • Turbine bucket having part-span connector and profile
    Patent number: 10196908
    Abstract: Various embodiments of the invention include turbine buckets and systems employing such buckets. Various particular embodiments include a turbine bucket having: an airfoil having: a suction side; a pressure side opposing the suction side; a leading edge spanning between the pressure side and the suction side; and a trailing edge opposing the leading edge and spanning between the pressure side and the suction side; a pair of part-span connectors extending from the airfoil at the suction side and the pressure side, respectively, wherein each of the pair of part-span connectors is located between approximately 40 percent and approximately 70 percent of a radial span measured from the base to a radial tip of the airfoil; and a base connected with a first end of the airfoil along the suction side, pressure side, trailing edge and the leading edge.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: February 5, 2019
    Assignee: General Electric Company
    Inventors: Craig Allen Bielek, Kelvin Rono Aaron, Michael David McDufford
  • METHOD OF TREATING GRAFT VERSUS HOST DISEASE
    Publication number: 20190030080
    Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.
    Type: Application
    Filed: September 14, 2018
    Publication date: January 31, 2019
    Applicant: Mesoblast, Inc.
    Inventors: Silviu Itescu, Michael David Schuster
  • PREVENTION OF SSRI-INDUCED GASTROINTESTINAL DYSFUNCTION WITH A 5-HT4 RECEPTOR ANTAGONIST
    Publication number: 20190030039
    Abstract: The present invention provides, inter alia, methods for treating or preventing a disorder in a subject exposed to an agent that antagonizes the serotonin reuptake transporter (SERT), such as an SSRI, in utero or by consumption by the subject of breast milk from the subject's mother, by administering a 5-HT4 receptor antagonist, for example, to the subject's mother.
    Type: Application
    Filed: January 20, 2017
    Publication date: January 31, 2019
    Inventors: Kara Gross Margolis, Michael David Gershon
  • SYSTEM AND METHOD FOR SQUADRON COMMUNICATION EXCHANGE BETWEEN RECEIVING DEVICES
    Publication number: 20190034956
    Abstract: A method and system for communication protocol pass reduction amongst recipient nodes capable of receiving broadcast messages, the recipient nodes functioning as different decisions points for determination of a passing joint set of nodes for squadron communication therebetween. The method and system provide squadron communication between different ones of the recipient nodes, wherein one of the recipient nodes becomes a squadron leader node upon a selection of a specific broadcast message for distribution to other recipient nodes for acceptance. The squadron leader node and the other recipient nodes upon acceptance form the passing joint set of nodes for squadron communication therebetween.
    Type: Application
    Filed: July 25, 2018
    Publication date: January 31, 2019
    Inventors: Elizabeth Acomb Crosby, Hugh Britton Sanderford, III, Adele Humphreys Sanderford, Reza Moghtaderi Esfahani, Charles Thomas Douglas, JR., Michael David Newton, Hugh Britton Sanderford, JR.
  • Online Platform For Streaming Electronic Publications To Subscriber Devices
    Publication number: 20190036994
    Abstract: An online streaming platform that allows subscribers to access a fixed number of e-books within a library for a fee paid on a periodic basis. The online streaming platform includes a plurality of cloud servers storing subscriber information and a plurality of storage servers in communication with the plurality of cloud servers. At least one of the storage servers stores a e-textbook library containing the contents of a plurality of e-books. The e-books are not saved or downloadable to a client device of a subscriber.
    Type: Application
    Filed: January 13, 2017
    Publication date: January 31, 2019
    Applicant: Kennesaw State University Research and Service Foundation, Inc.
    Inventors: Paul Ngaele NGALLE, Michael David RUSSELL, Muhatashim ZARIF
  • Allosteric Modulators of the Mu Opioid Receptor
    Publication number: 20190030020
    Abstract: Disclosed herein are compounds which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided.
    Type: Application
    Filed: July 27, 2018
    Publication date: January 31, 2019
    Applicant: Chiromics, LLC
    Inventors: Joel Francis Austin, Michael David VanHeyst, James S. Harvey, Elizabeth Gerig Rowley, Christophe Lamarque-Lacoste
  • ADHESION OF THERMAL SPRAY COATINGS OVER A SMOOTH SURFACE
    Publication number: 20190032189
    Abstract: A coated component is generally provided, along with methods of forming such a coating system. The coated component includes a substrate having a surface with a coating system thereon. The coating system may include a columnar thermal barrier coating (TBC) over the surface of the substrate, with the columnar TBC including surface-connected voids. An intermediate layer is over the columnar TBC layer. The intermediate layer has a surface opposite of the columnar TBC that is rougher than the surface of the columnar TBC. A second TBC is over the intermediate layer.
    Type: Application
    Filed: July 31, 2017
    Publication date: January 31, 2019
    Inventors: Dianying Chen, Ming Fu, Michael David Clark, Douglas Gerard Konitzer
  • System and method for fluid injection
    Patent number: 10190383
    Abstract: A fluid injection system includes a choke valve having at least one inlet. The system also includes a water injection line extending between a water supply and the choke valve, and the water injection line is configured to flow water from the water supply into a first inlet of the at least one inlet of the choke valve. The system also includes a polymer injection line extending from a polymer supply toward the choke valve, and the polymer injection line is configured to flow a polymer in a substantially non-inverted state from the polymer supply toward the choke valve. The choke valve is configured to receive the water and the polymer and to facilitate inversion of the polymer as the water and the polymer flow through the choke valve.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: January 29, 2019
    Assignee: Cameron International Corporation
    Inventors: Michael David Mullin, Kevin Peter Minnock
  • Dialysis Machine Support Assemblies and Related Systems and Methods
    Publication number: 20190022295
    Abstract: In some aspects, a dialysis machine support assembly includes a platform configured to support a dialysis machine and a drive assembly configured to move the platform vertically.
    Type: Application
    Filed: August 29, 2018
    Publication date: January 24, 2019
    Inventors: Gurpreet Singh, Sean Farrell, Michael David Young
  • FLEXIBLE BATTERY WITH LIQUID METAL ELECTRODE
    Publication number: 20190027762
    Abstract: An electrochemical energy-storage cell comprises a flexible positive electrode and a flexible negative electrode including a gallium-based liquid metal dispersed on a flexible wire mesh. The electrochemical energy-storage cell also comprises a membrane having one face in contact with the flexible positive electrode and an opposing face in contact with the flexible negative electrode.
    Type: Application
    Filed: July 19, 2017
    Publication date: January 24, 2019
    Applicant: Microsoft Technology Licensing, LLC
    Inventors: Michael David DICKEY, James David HOLBERY, Collin Brittain EAKER
  • Surge protection module
    Patent number: D840950
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: February 19, 2019
    Assignee: Diversified Technology Group, Inc.
    Inventor: Michael David Gattis
  • Surge protection receptacle
    Patent number: D840951
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: February 19, 2019
    Assignee: Diversified Technology Group, Inc.
    Inventor: Michael David Gattis