Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: An applicator instrument for dispensing surgical fasteners includes a housing, an elongated shaft, surgical fasteners disposed in the elongated shaft, a firing system for dispensing the surgical fasteners, a firing rod disposed within the elongated shaft and movable within a first plane, and an advancer disposed within the elongated shaft and moveable within a second plane. An actuator is coupled with the advancer for moving the advancer back and forth between retracted and extended positions. A staging assembly at the distal end of the elongated shaft aligns a leading surgical fastener with the first plane. The staging assembly includes a biasing device that is configured to be deflected away from the first plane by the advancer when the advancer is in the extended position and the staging assembly is configured to spring back into alignment with the first plane when the advancer returns back to the retracted position.

Abstract: Disclosed herein are embodiments of composite hexagonal ferrite materials formed from a combination of Y phase and Z phase hexagonal ferrite materials. Advantageously, embodiments of the material can have a high resonant frequency as well as a high permeability. In some embodiments, the materials can be useful for magnetodielectric antennas.

Abstract: Methods and systems are provided for dynamic interaction with an augmented reality environment. In some embodiments, the systems and methods are directed at dynamically interacting with machinery within the augmented reality environment via an augmented reality device.

Abstract: Methods and systems are provided for dynamic interaction with an augmented reality environment. In some embodiments, the systems and methods are directed at dynamically interacting with machinery within the augmented reality environment via an augmented reality device.

Abstract: A respiratory disease analytics system provides respiratory disease risk reports to a patient, provider, or third-party entity describing a patient's risk of experiencing a medication usage event given data in a geographic region. Regional data, including air pollutant conditions, weather conditions, demographic information, built environment factors, and regional health conditions for a geographic region are accessed from other sources and assigned based on event data recorded during a medicament usage event, as collected by sensors associated with the patient's medicament device/s. The regional data is assigned to medicament usage events occurring within a period of time. The assigned regional data is analyzed to determine an expected number of medication usage events for the geographic region occurring over the period of time.

Abstract: In one aspect, a system includes a movable barrier operator configured to open and close a movable barrier; at least one ultra-wideband device associated with the movable barrier operator and electrically configured to receive ultra-wideband radio frequency signals; and a processor operatively connected to the at least one ultra-wideband device and configured to use the ultra-wideband radio signals to determine a status of the movable barrier.

Abstract: Light-emitting devices including solid-state light-emitting devices, light-emitting diode (LED) devices, and LED packages with support elements for improved near-field and far-field emissions are disclosed. LED chips may be mounted to support elements in a manner that directs light through the support elements in desired emission directions. Support elements include optical structures that spread and mix light laterally within the support element. Optical structures include various light-altering layers, such as light-diffusing layers or light-reflective layers, that are arranged to effectively increase internal reflections for lateral spreading of light. Patterned arrangements of light-altering layers include portions that mask direct emissions for LED chips, thereby redistributing emissions laterally to increase near-field and/or far-field uniformity across an increased portion of emitting surfaces.

Abstract: A fire suppression nozzle includes a first support plate, a conduit including an inlet and an outlet, and a baffle made of a porous material extending from the first support plate and at least partially surrounding the outlet to form an interior in fluid communication with the outlet and an end opening. The conduit is configured to receive an inert gas at the inlet and provide the inert gas to the interior of the baffle via the outlet such that the inert gas exits the outlet and passes at least partially through the baffle. The nozzle includes a sound absorbing member extending across the end opening to at least partially enclose the interior, and also includes a sound absorbing insert composed of a sound absorbing material and a second support plate arranged against an outer face of the sound absorbing insert and coupled to the first support plate.

Abstract: Sulfonated polystyrene fibers having an average diameter from 450 nm to 2000 nm and a capacity from 0.05 meq/g to 2.0 meq/g.

Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: Filaments that contain a filament-forming material and an additive, nonwoven webs, and methods for making such filaments are provided.

Abstract: Support structures are used in certain additive fabrication processes to permit fabrication of a greater range of object geometries. For additive fabrication processes with materials that are subsequently sintered into a final part, an interface layer is formed between the object and support in order to inhibit bonding between adjacent surfaces of the support structure and the object during sintering.

Abstract: A wearable sound device includes a venting device including a film structure and an actuator and a driving circuit configured to be controlled by a controller and to drive the actuator, such that the film structure is controlled to form a vent or to seal the vent. The controller is coupled to a sensing device configured to generate a sensing result and determine whether to seal the vent according to the sensing result. The film structure partitions a space within the wearable sound device into a first volume and a second volume. The first volume is connected to or to be connected to an ear canal of a wearable sound device user. The second volume is connected to or to be connected to an ambient of the wearable sound device. The first volume and the second volume are connected via the vent when the vent is formed.

Abstract: A computational pixel imaging device can include multiple digitizing counters per pixel that can be used to execute simultaneous signal-processing threads on acquired image data. The imaging device can also include infinite dynamic range sensing and perform signal down-sampling.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: Described herein are systems and methods for generating a computing network from natural language descriptions of the computing network are provided. In one or more examples, the systems and methods described below can be used harvest publically available (or even privately available) natural language descriptions of a computing network, and convert those descriptions into an operational replica of the described computing network. By harvesting both publically available data, as well as other resources, the systems and methods described herein can allow for an analyst tasked with analyzing a given computing network to generate a fully operational replica of the computing network without having to have direct access to the network. In one or more examples, the analyst can recreate a fully-functional replica of the network to be analyzed based on partial descriptions of the computing network, thereby greatly improving the level of analysis capable of being performed.

Abstract: A launch vehicle dispenser attach structure is disclosed. The launch vehicle dispenser attach structure includes a launch vehicle adapter, and a polygonal extruded cylinder comprising tapered side and an essentially closed end. The polygonal extruded cylinder connects to the launch vehicle adapter. The tapered sides and the closed end of the polygonal extruded cylinder provide mounting interfaces for connecting satellite dispensers. A mounting interface of the mounting interfaces includes a separation ring for transforming the launch vehicle dispenser attach structure into a free flying satellite. The launch vehicle dispenser attach structure is particularly useful for attaching multiple payload separation systems to launch vehicle.

Abstract: Described herein are compositions and methods that utilize complementary polymerization reactions to simultaneously generate one or more polymeric materials, including crosslinked polymer matrices, tethered inter-penetrating network, heterogenous polymer blends, or homogeneous polymer blends. The provided compositions and methods utilize the combination of an energy demanding step-growth reaction with a highly exothermic reaction to drive the energy demanding reaction by chemical heating and avoid issues associated with thermal runaway, such as solution boiling or unwanted biproducts.

Abstract: An enclosure system for a building includes an entryway for the building defined by opposing left and right frame-side jambs and a frame-side transom extending between the left and right frame-side jambs, and a temporary enclosure system removably installable within the entryway. After removing the temporary enclosure system from the entryway, the enclosure system further includes a left door-side jamb attachable to the left frame-side jamb to form an assembled left jamb, a right door-side jamb attachable to the right frame-side jamb to form an assembled right jamb, and a door-side transom attachable to the frame-side transom to form an assembled transom. One or more doors are hung within the entryway and extend laterally between the assembled left and right jambs and vertically to the assembled transom.