Abstract: The present disclosure relates generally to methods of producing multiple embryos from one or more donor embryos comprising embryonic cells that are developmentally equivalent to embryonic cells from a 16-cell embryo or a pre-compacted morula. More particularly, the method of the disclosure comprises unzipping said donor embryos and expanding one or more aggregates of blastomeres obtained from the donor embryo(s) to produce multiple blastocysts from the donor embryo(s). The present disclosure also relates to the use of such methods in animal breeding.

Abstract: A tunable light source (10) that generates a source beam (12) having a tunable source frequency (12a) includes an emitter assembly (14), a first frequency generator (16), and a first filter (18). The emitter assembly (14) emits an emitter beam (14a), and the first frequency generator (16) receives the emitter beam (14a) and generates a plurality of first frequency lines (16b). The first filter (18) filters the first frequency lines (16b) to transmit a first filter beam (18a) that includes only one of the first frequency lines (16b). The light source (10) can include a second frequency generator (20) that converts the first filter beam (18a) into a plurality of second frequency lines (20b), and a second filter (22) that filters the second frequency lines (20b) to provide a second filter beam (22a) having the source frequency (12a).

Abstract: Various exemplary attachments for hair care appliances and methods of using attachments for hair care appliances are provided. In general, a hair care attachment in an exemplary embodiment is in the form of a brush accessory that has a hollow body having first and second region, an attachment collar at a first end of the hollow body and having an inlet for receiving airflow, a plurality of bristles positioned along the first region of the hollow body, a plurality of outlet openings positioned along the first region of the hollow body adjacent the plurality of bristles, and a heater assembly positioned along the second region of the hollow body.

Abstract: The present invention relates to fusion proteins comprising an insulin receptor agonist fused to a human IgG Fc region through the use of a peptide linker, and the use of such fusion proteins in the treatment of diabetes. The fusion protein of the present invention has an extended time action profile and is useful for providing basal glucose control for an extended period of time.

Abstract: A digital medicine companion for managing skin diseases (e.g., atopic dermatitis, psoriasis) may include patient wearable devices passively collecting patient data, patient user devices with healthcare applications for the patient to enter health related data, central analytics for flare prediction and disease progress tracking, and a clinician dashboard. For flare prediction, a prediction tool may be trained using the ground truth of recorded flare occurrences for the trained model to predict whether observed scratch events may result in a flare. Upon predicting a likely flare, alert notifications may be generated, e.g., for a clinician and/or the patient. Furthermore, a baseline may be established based on the data passively gathered from the wearables and actively gathered from the patient user devices. The continuously collected data may be compared against the established baseline. Upon detecting a significant deviation, alerts may be sent to the patient and/or the clinician.

Abstract: Various exemplary attachments for hair care appliances and methods of using attachments for hair care appliances are provided. In general, a hair care attachment in an exemplary embodiment is in the form of a brush accessory that has a hollow body having first and second region, an attachment collar at a first end of the hollow body and having an inlet for receiving airflow, a plurality of bristles positioned along the first region of the hollow body, a plurality of outlet openings positioned along the first region of the hollow body adjacent the plurality of bristles, and a heater assembly positioned along the second region of the hollow body.

Abstract: Various exemplary attachments for hair care appliances and methods of using attachments for hair care appliances are provided. In general, a hair care attachment in an exemplary embodiment is in the form of a brush accessory that has a hollow body having first and second region, an attachment collar at a first end of the hollow body and having an inlet for receiving airflow, a plurality of bristles positioned along the first region of the hollow body, a plurality of outlet openings positioned along the first region of the hollow body adjacent the plurality of bristles, and a heater assembly positioned along the second region of the hollow body.

Abstract: Various exemplary attachments for hair care appliances and methods of using attachments for hair care appliances are provided. In general, a hair care attachment in an exemplary embodiment is in the form of a brush accessory that has a hollow body having first and second region, an attachment collar at a first end of the hollow body and having an inlet for receiving airflow, a plurality of bristles positioned along the first region of the hollow body, a plurality of outlet openings positioned along the first region of the hollow body adjacent the plurality of bristles, and a heater assembly positioned along the second region of the hollow body.

Abstract: A hair care appliance is provided and includes a diverter configured to divert a portion of airflow from an airflow path through the body into the handle to cool electrical components disposed within the handle. In an exemplary embodiment, a hair care appliance is provided having a handle and a body coupled to the handle. A fan assembly is disposed within the body and is configured to generate an airflow. A first portion of the airflow can flow from an inlet of the body to an outlet of the body. A second portion of the airflow can flow into the handle to cool at least one electrical component provided in the handle.

Abstract: An apparatus for thinning and reducing the surface roughness of a substrate, a method for thinning and reducing the surface roughness of a substrate and a method of reducing the thickness of a substrate are provided herein. The generated etch routine that will provide the target variation in thickness of the substrate and a target average substrate thickness is based on the measured variation in thickness and the measured average substrate thickness of the substrate.

Abstract: A storage solution that provides substantial advantages over existing storage solutions. The storage solution can include a latch system, a rack system or a display system, any one or more of which can be included with a utility box.

Abstract: The invention relates to a method for attaching a non-soluble active pharmaceutical ingredient (API) to a micro sphere produced by thermally induced phase separation (TIPS) comprising: i) mixing the micro sphere with an aqueous solution to form a first composition; ii) dissolving the non-soluble API in a first solvent and subsequently adding the non soluble API dissolved in the first solvent to the first composition to form a second composition; and iii) mixing the second composition. The invention further relates to a micro sphere produced by thermally induced phase separation which has a non-soluble API bound to its surface and a composition comprising said micro sphere for use in therapy.

Abstract: A storage solution that provides substantial advantages over existing storage solutions. The storage solution can include a latch system, a rack system or a display system, any one or more of which can be included with a utility box.

Abstract: A semiconductor wafer dicing process is disclosed for dicing a wafer into individual dies. Scribe lines are formed within a polymer coating to expose regions of wafer to form a pre-processed product. The pre-processed product within the chamber is plasma etched to remove the exposed regions of the wafer to separate the individual dies and form a processed product. A frame cover is then removed and the processed product, wafer frame and adhesive tape are exposed to an oxygen plasma within the chamber to partially remove an outermost region of the polymer coating, which is most heavily contaminated with fluorine, to leave a residual polymer coating on the individual dies and form a post-processed product. The residual polymer coating on the individual dies of the post-processed product is then removed.

Abstract: A semiconductor wafer dicing process is disclosed for dicing a wafer into individual dies. Scribe lines are formed within a polymer coating to expose regions of wafer to form a pre-processed product. The pre-processed product within the chamber is plasma etched to remove the exposed regions of the wafer to separate the individual dies and form a processed product. A frame cover is then removed and the processed product, wafer frame and adhesive tape are exposed to an oxygen plasma within the chamber to partially remove an outermost region of the polymer coating, which is most heavily contaminated with fluorine, to leave a residual polymer coating on the individual dies and form a post-processed product. The residual polymer coating on the individual dies of the post-processed product is then removed.

Abstract: The invention relates to methods for attaching therapeutic agents to structures produced by thermally induced phase separation as well as methods for coating devices and producing multi-layered microspheres.

Abstract: A utility box or storage system that includes one or more configurable storage compartments. The utility box or storage system can comprise a compartment having a first wall that includes a guide and a second wall, and a plurality of storage units, including at least one of the plurality of storage units that implants into the compartment between the first wall and the second wall. The at least one storage unit can include a ridge that aligns with the guide. The guide can engage the ridge to guide the storage unit during implantation.

Abstract: A utility box or compartment divider system that includes one or more configurable storage compartments. The utility box or compartment divider system can comprise a divider mate and a divider unit having a countermate that engages the divider mate. The divider unit can include a plurality of apertures that allow molecules to flow freely therethrough. The divider unit can include a retainer compartment configured to hold an AC/AM device.