Abstract: A bipolar electrosurgical fusion/sealer and dissector is provided that is arranged to simultaneously fuse and cut tissue captured between jaws of the instrument. The jaws include particularly positioned, shaped and/or oriented electrodes along with a compressible landing pad to perform the simultaneous fusion and cutting of tissue. An electrosurgical generator is arranged to supply RF energy through the instrument and monitors a phase angle of the supplied RF energy and adjusts or terminates the supplied RF energy based on the monitored phase angle to optimally fuse and dissect the tissue.

Abstract: The disclosure relates to a chute liner for mounting on a shelf of a material transfer chute. The shelf has at least one locking formation aperture formed therein. The chute liner has a base for mounting on the shelf. The base has an operatively upper surface that comes into contact with material passing through the chute and an opposed operatively lower surface. The base has at least one mounting formation that depends from the operatively lower surface of the base that defines a passage which in use is passed through the locking formation aperture in the shelf. The chute liner also has a locking member passed through the passage until it operatively engages the mounting formation to lock the base to the shelf.

Abstract: An exemplary shingle includes at least one coated shingle sheet defining a headlap portion and a tab portion each having opposed upper and lower surfaces. A first line of adhesive is adhered to one of the upper surface of the headlap portion and the lower surface of the tab portion, and includes a first thermally activated adhesive material. A second line of adhesive is adhered to one of the upper surface of the headlap portion and the lower surface of the tab portion, and includes a second thermally activated adhesive material having a minimum activation temperature less than a minimum activation temperature of the first thermally activated adhesive material.

Abstract: The present disclosure relates to compositions and methods for targeting vesicles to specific tissue and cell types. Also disclosed are compositions and methods for delivering therapeutic molecules, including nucleic acids and nucleic acid derivatives, to specific cells or tissues using vesicles with cell and tissue-specific targeting moieties expressed on their surfaces.

Abstract: Spirocyclic 2,3-dihydro-7-azaindole compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the spirocyclic 2,3-dihydro-7-azaindole compounds.

Abstract: An aerosol-generating device for heating an aerosol-generating article is provided, the device including: a housing having an opening; a chamber within the housing to receive the article; a heater assembly within the housing to heat the chamber; a part at or proximate to the opening to move between a first position, in which the article is insertable into the chamber, and a second position, in which the part has reduced a size of the opening; and a controller coupled to the part to actuate the part to move between the first and the second positions, the part being configured to move from the first position to the second position in a first direction, and the controller being configured to move in a second direction to cause the part to move from the first position to the second position, the second direction being different from the first direction.

Abstract: The present disclosure provides methods of treating overweight or obese patients with or without type 2 diabetes mellitus. The treatment comprises administration of a dual GLP-1 receptor and GIP receptor agonist.

Abstract: An aerosol-generating device for heating an aerosol-generating article is provided, the device including: a housing having an opening; a chamber within the housing to receive at least a portion of the article through the opening; a heater assembly within the housing and including a heating element to heat at least a portion of the chamber; a mechanism including at least one member at or proximate to the opening and configured to move between a first position in which the article can be inserted into the chamber via the opening, and a second position in which the member has reduced a size of the opening relative to a size of the opening when the member is in the first position; and at least one guide track along which the member is configured to slide when the member moves between the first and the second positions.

Abstract: Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

Abstract: Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

Abstract: A garment includes a torso portion having a neck opening and is configured to be supported by shoulders of a wearer. A hood is coupled to a back of the torso portion about the neck opening and is configured to fit on a head of the wearer in a hood up position. A first fastener is supported by a back of the hood and is spaced a first distance from the neck opening. A second fastener is supported by a back of the torso portion and is spaced a second distance from the neck opening to releasably secure the hood via engagement with the first fastener in a hood down position.

Abstract: An aerosol-generating device for heating an aerosol-generating article is provided, the device including: a housing having an opening; a chamber within the housing to receive at least a portion of the article through the opening; a heater assembly within the housing and including a heating element to heat at least a portion of the chamber; a mechanism including at least one member at or proximate to the opening and configured to move between a first position in which the article can be inserted into the chamber via the opening, and a second position in which the member has reduced a size of the opening relative to a size of the opening when the member is in the first position; and at least one guide track along which the member is configured to slide when the member moves between the first and the second positions.

Abstract: An aerosol-generating device for heating an aerosol-generating article is provided, the device including: a housing having an opening; a chamber disposed within the housing, and configured to receive at least a portion of the article through the opening; a heater assembly disposed within the housing and including a heating element configured to heat at least a portion of the chamber; and a holding mechanism including at least one holding member disposed at or proximate to the opening of the housing and configured to move between: a first position, in which the article can be inserted into the chamber via the opening, and a second position, in which the holding member has reduced a size of the opening relative to another size of the opening when the holding member is in the first position.

Abstract: The disclosure relates to a chute liner for mounting on a shelf of a material transfer chute. The shelf has at least one locking formation aperture formed therein. The chute liner has a base for mounting on the shelf. The base has an operatively upper surface that comes into contact with material passing through the chute and an opposed operatively lower surface. The base has at least one mounting formation that depends from the operatively lower surface of the base that defines a passage which in use is passed through the locking formation aperture in the shelf. The chute liner also has a locking member passed through the passage until it operatively engages the mounting formation to lock the base to the shelf.

Abstract: The disclosed technology teaches integrating theme management of user interfaces that implement an authentication journey for hosted services, receiving user input and responsively configuring a switch block node used in the journey. A first configured control of the node selects an authentication-related state variable to set a switch and a second configured control specifies alternative settings. Also receiving user input and responsively composing a script used in the node to process the state variable and select among the switch settings, responsive to the state variable, and receiving user input and responsively creating a visual branding theme. Further included is receiving user input and responsively composing a directed graph in which nodes that implement the authentication journey are connected, applying the themes to named theme nodes, positioning and connecting the switch block node to subsequent named theme nodes, to which the switch block node alternatively directs a flow of the journey.

Abstract: A wall structure having a horizontal base stud, which wall structure has an upper wall panel, and a horizontal base stud, wherein the base stud has openings to allow for liquids to escape in the event of a plumbing leak, and additional openings to allow for air flow from the exterior to the interior of the wall structure.

Abstract: Methods, systems, and computer storage media for providing a dynamically weighted unobserved component model (“DW-UCM”) in a demand forecasting engine of a data analytics system. Dynamic weighting is performed based on a machine learning framework that includes tools, interfaces, and a library for developing improved machine learning models (e.g., dynamic demand forecasting models) of a dynamic weighting machine learning pipeline. In particular, the dynamic weighting machine learning pipeline can include a first module that is configured to predict if a segment (e.g., travel segment) under evaluation is open or closed (e.g., due to a restriction or rule), a second module that forecasts near-term recovery (e.g., approx. 0 - 4 weeks), and a third module that predicts longer term recovery.

Abstract: A wall structure having a horizontal base stud, which wall structure has an upper wall panel, and a horizontal base stud, wherein the base stud has openings to allow for liquids to escape in the event of a plumbing leak, and additional openings to allow for air flow from the exterior to the interior of the wall structure.

Abstract: The present invention relates to method for production of a slurry for homogenized tobacco material, said method comprising: Selecting tobacco of one or more tobacco types; Coarse grinding said tobacco; Blending said tobacco of one or more tobacco types; and Fine grinding said tobacco of one or more tobacco types.

Abstract: Container systems employing linking subsystems for coupling enclosure bodies, and related methods are disclosed. A container system may include first and second enclosure bodies. Each of the bodies contains a wall structure enclosing an inner space and a lip forming a passageway through the wall structure. The container system also includes a linking subsystem configured to reversibly couple the wall structures of the bodies together. The user may uncouple the bodies from each other and recouple them together as desired. In this manner, the container system offers a more stable combination resistant to falling over and an organizational flexibility to couple the bodies together when items within the bodies and desired to be used together.