Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.

Abstract: A fuel assembly for a gas turbine engine includes a fuel supply tube, a fuel port, a fuel manifold, and a fuel manifold adapter. The fuel supply tube is configured to convey a fuel. The fuel port is fluidly coupled to the fuel supply tube and configured to receive the fuel from the fuel supply tube. The fuel manifold includes a fuel inlet and a plurality of fuel outlets. The fuel inlet is fluidly coupled to the fuel port and configured to receive the fuel from the fuel port. The fuel manifold adapter includes a first mount portion and a second mount portion. The first mount portion is connected to the fuel port. The first mount portion is moveable relative to the second mount portion.

Abstract: A fuel assembly for a gas turbine engine includes a fuel supply tube, a fuel port, a fuel manifold, and a fuel manifold adapter. The fuel supply tube is configured to convey a fuel. The fuel port is fluidly coupled to the fuel supply tube and configured to receive the fuel from the fuel supply tube. The fuel manifold includes a fuel inlet and a plurality of fuel outlets. The fuel inlet is fluidly coupled to the fuel port and configured to receive the fuel from the fuel port. The fuel manifold adapter includes a first mount portion and a second mount portion. The first mount portion is connected to the fuel port. The first mount portion is moveable relative to the second mount portion.

Abstract: An orifice pack is provided for delivering pressurized air to a compressor bleed valve of a gas turbine engine. The orifice pack has a diffusion chamber in serial flow communication with a tapering passage and a first outlet passage for venting a first portion of the pressurized air from the diffusion chamber. A second outlet passage branches off from the diffusion chamber at an axial location between the inlet and the tapering passage. The second outlet passage is fluidly connected to the compressor bleed valve for directing a second portion of the pressurized air from the diffusion chamber to the compressor bleed valve.

Abstract: An assembly is provided for a gas turbine engine. This gas turbine engine assembly includes a case, a housing, a component and a spring element. The case includes an aperture that extends axially along an axis through the case. The housing is attached to the case with a cavity formed by and axially between the housing and the case. The component includes a base and a projection. The base is disposed within the cavity and axially engages the case. The projection projects out from the base and axially through the aperture. The spring element is disposed within the cavity. The spring element is compressed axially between and engages the base and the housing.

Abstract: Methods and systems for filtering pressurized air used to control a compressor bleed valve of a gas turbine engine are provided. One method comprises receiving the pressurized air in a conduit via an inlet of the conduit, releasing a first portion of the pressurized air out of the conduit via an outlet of the conduit, releasing a second portion of the pressurized air from the conduit via a port disposed between the inlet and the outlet of the conduit, directing the second portion of the pressurized air from the port to a filter along an upward flow path, filtering the second portion of the pressurized air using the filter, and directing the second portion of the pressurized air from the filter toward the compressor bleed valve.

Abstract: The gas turbine engine can have a pneumatic actuator; an intake device secured to a gas path wall delimiting the gas path, the intake device having a tubular body protruding from the gas path wall into the gas path and an inlet aperture formed in the tubular body, the inlet aperture spaced-apart from the gas path wall and facing downstream relative a flow orientation of the gas path, the intake device having an internal conduit extending from the inlet aperture, along the tubular body, to an outlet across the gas path wall; and a fluid line fluidly connecting the outlet of the intake device to the pneumatic actuator.

Abstract: The gas turbine engine can have a pneumatic actuator; an intake device secured to a gas path wall delimiting the gas path, the intake device having a tubular body protruding from the gas path wall into the gas path and an inlet aperture formed in the tubular body, the inlet aperture spaced-apart from the gas path wall and facing downstream relative a flow orientation of the gas path, the intake device having an internal conduit extending from the inlet aperture, along the tubular body, to an outlet across the gas path wall; and a fluid line fluidly connecting the outlet of the intake device to the pneumatic actuator.

Abstract: An orifice pack is provided for delivering pressurized air to a compressor bleed valve of a gas turbine engine. The orifice pack has a diffusion chamber in serial flow communication with a tapering passage and a first outlet passage for venting a first portion of the pressurized air from the diffusion chamber. A second outlet passage branches off from the diffusion chamber at an axial location between the inlet and the tapering passage. The second outlet passage is fluidly connected to the compressor bleed valve for directing a second portion of the pressurized air from the diffusion chamber to the compressor bleed valve.

Abstract: Methods and systems for filtering pressurized air used to control a compressor bleed valve of a gas turbine engine are provided. One method comprises receiving the pressurized air in a conduit via an inlet of the conduit, releasing a first portion of the pressurized air out of the conduit via an outlet of the conduit, releasing a second portion of the pressurized air from the conduit via a port disposed between the inlet and the outlet of the conduit, directing the second portion of the pressurized air from the port to a filter along an upward flow path, filtering the second portion of the pressurized air using the filter, and directing the second portion of the pressurized air from the filter toward the compressor bleed valve.

Abstract: The present invention relates to new anti-angiopoietin 2 (ANGPT2) neutralizing antibodies for therapeutic and diagnostic methods and composition using them.

Abstract: An assembly for a gas turbine engine has a support structure and a tube configured to circulate lubricant and mounted to the support structure, a sacrificial sleeve extending around the tube and disposed between the support structure and the tube, the sacrificial sleeve welded to the support structure. A method of mounting a fluid carrying tube to a support structure in a gas turbine engine is provided.

Abstract: The present invention relates to new anti-angiopoietin 2 (ANGPT2) neutralizing antibodies for therapeutic and diagnostic methods and composition using them.

Abstract: A boss for a case of a gas turbine engine, has: an elongated body having a proximal end securable to the case, the elongated body extending from the proximal end along a boss axis to a distal end, and a flange secured to the elongated body at the distal end, the flange securable to an accessory.

Abstract: A boss for a case of a gas turbine engine, has: an elongated body having a proximal end securable to the case, the elongated body extending from the proximal end along a boss axis to a distal end, and a flange secured to the elongated body at the distal end, the flange securable to an accessory.

Abstract: An assembly for a gas turbine engine has a support structure and a tube configured to circulate lubricant and mounted to the support structure, a sacrificial sleeve extending around the tube and disposed between the support structure and the tube, the sacrificial sleeve welded to the support structure. A method of mounting a fluid carrying tube to a support structure in a gas turbine engine is provided.

Abstract: The present invention encompasses compounds of the formula (I) wherein the groups R1, Cy and Y are defined herein, which are suitable for the treatment of diseases related to BTK, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

Abstract: The present invention relates to new anti-angiopoietin 2 (ANGPT2) neutralizing antibodies for therapeutic and diagnostic methods and composition using them.

Abstract: A fuel nozzle for a gas turbine engine includes a stem having a monolithic stem body extending longitudinally between a first end and a second end. The monolithic stem body has a radially outer surface and at least one helical fuel passage extending through the monolithic stem body and disposed inwardly from the radial outer surface. The at least one helical fuel passage extends helically through the monolithic stem body about a passage axis extending between the first and second ends.

Abstract: The present invention encompasses compounds of the formula (I) wherein the groups R1, Cy and Y are defined herein, which are suitable for the treatment of diseases related to BTK, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.