Abstract: In order to provide a flow element by means of which a fluid can be guided and/or distributed over a surface as uniformly as possible, it is proposed that the flow element comprises a plate-like main body, which has a channel structure, wherein the channel structure comprises two or more paths, which connect an inlet side of the channel structure to an outlet side of the channel structure, wherein the two or more channel paths each have one or more meandering segments, wherein meandering segments of channel paths different from each other are nested in each other.

Abstract: An electrochemical device is provided that includes a stack of a plurality of electrochemical units that succeed one another in a stacking direction and each include an electrochemically active membrane electrode assembly, at least one gas diffusion layer and a bipolar plate having at least one flow field, in which at least one flow field is sealed off simply and reliably and the occurrence of parasitic flows is prevented, wherein at least one bipolar plate has at least one edge web, which borders a flow field of the bipolar plate and is in contact with a gas diffusion layer adjacent to the bipolar plate, and wherein the electrochemical device further includes at least one flow field seal element that seals off the flow field bordered by the edge web and is in contact with the edge web and in contact with the gas diffusion layer.

Abstract: In order to produce an electro-chemical unit for a fuel cell stack in which a plurality of electro-chemical units follow one another along a stacking direction wherein the electro-chemical unit includes a membrane electrode unit having an anode-side electro-chemically active surface which has an outer border that is defined by an anode-side bordering element and wherein the electro-chemical unit also includes a cathode-side electro-chemically active surface which has an outer border that is defined by a cathode-side bordering element in such a way as to prevent enhanced aging of the membrane electrode unit due to regions of the membrane electrode unit only being supplied with an oxidizing agent, it is proposed that the outer border of the anode-side electro-chemically active surface be displaced outwardly at least in sections thereof with respect to the outer border of the cathode-side electro-chemically active surface in a direction running perpendicularly to the stacking direction.

Abstract: To provide a flow element which in particular is used as a component of a bipolar plate in electrochemical devices, which is stable and permits efficient flow guiding, it is proposed that the flow element comprises a plate-like main body that is formed as a shaped sheet metal product and has a channel structure, wherein the channel structure comprises a plurality of channels which are formed by recesses in the main body and are separated from one another by raised portions of the main body, wherein there is provided at least one region with normal level difference that defines, with respect to a height direction running perpendicular to two main directions of extent of the main body, a height difference between a recess and an adjoining raised portion, wherein there is provided at least one region with reduced level difference, in which a height difference between a recess and an adjoining raised portion is less than the normal level difference, wherein the at least one region with reduced level difference co

Abstract: In order to provide a flow element by means of which a fluid can be guided and/or distributed over a surface as uniformly as possible, it is proposed that the flow element comprises a plate-like main body, which has a channel structure, wherein the channel structure comprises two or more paths, which connect an inlet side of the channel structure to an outlet side of the channel structure, wherein the two or more channel paths each have one or more meandering segments, wherein meandering segments of channel paths different from each other are nested in each other.

Abstract: An electrochemical device comprises a stack consisting of a plurality of electrochemical units which succeed one another along a stack direction and which each include a membrane electrode arrangement, a bipolar plate and at least one sealing element, at least one medium channel which extends along the stack direction, a flow field through which a medium can flow from the medium channel to another medium channel, and a connection channel through which the flow field and the medium channel are in fluid connection with one another, wherein the sealing arrangement includes a connection channel region in which the sealing arrangement crosses the connection channel, and at least one neighboring region which is located in front of or behind the connection channel region in the longitudinal direction of the sealing arrangement, wherein the sealing arrangement has a lower average height in the connection channel region than in the neighboring region.

Abstract: The present invention relates to novel compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof that are useful in the treatment and/or prevention of human and animal bacterial infections and associated diseases and conditions; compositions containing such compounds; derivation of such compounds by fermentation and isolation, partial synthesis and total synthesis; methods of inhibiting bacterial growth; methods of treating, preventing or controlling bacterial infection; biologically pure cultures of bacterial strains from which such compounds may be produced; and processes for preparing compositions containing such compounds.

Abstract: A system and method for providing cloud performance capability estimation and supporting recommender systems by simulating bottleneck and its migration for any given complex application in a cost-efficient way are provided. To do this, first, the system and method builds an abstract performance model for an application based on the resource usage pattern of the application in an in-house test-bed (i.e., a white-box environment). Second, it computes relative performance scores of many different cloud configurations given from black-boxed clouds using a cloud metering system. Third, it applies the collected performance scores into the abstract performance model to estimate performance capabilities and potential bottleneck situations of those cloud configurations. Finally, using the model, it can support recommender systems by providing performance estimates and simulations of bottlenecks and bottleneck migrations between resource sub-systems while new resources are added or replaced.

Abstract: A method and system generate a workflow for the production of a three-dimensional document. A knowledge base contains production rules for several dimensional documents. The production rules relate to a plurality of jobs, i.e., units of work involved in the production of a dimensional document. The rules also identify human and/or mechanical resources required to complete each job. The system receives, from multiple service providers, capability information corresponding to each service provider's available resources. The capability information is associated with the production rules and stored in the knowledge base. When a user selects a dimensional document to be produced, the system selects appropriate production rules for the document, accesses the associated capability information, and automatically generates a workflow for the document. The system distributes various jobs in the workflow among at least two different service providers.

Abstract: The present invention relates to novel compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof that are useful in the treatment and/or prevention of human and animal bacterial infections and associated diseases and conditions; compositions containing such compounds; derivation of such compounds by fermentation and isolation, partial synthesis and total synthesis; methods of inhibiting bacterial growth; methods of treating, preventing or controlling bacterial infection; biologically pure cultures of bacterial strains from which such compounds may be produced; and processes for preparing compositions containing such compounds.

Abstract: A method and system generate a workflow for the production of a three-dimensional document. A knowledge base contains production rules for several dimensional documents. The production rules relate to a plurality of jobs, i.e., units of work involved in the production of a dimensional document. The rules also identify human and/or mechanical resources required to complete each job. The system receives, from multiple service providers, capability information corresponding to each service provider's available resources. The capability information is associated with the production rules and stored in the knowledge base. When a user selects a dimensional document to be produced, the system selects appropriate production rules for the document, accesses the associated capability information, and automatically generates a workflow for the document. The system distributes various jobs in the workflow among at least two different service providers.

Abstract: The invention relates to embodiments of an analysis system and to a method for analyzing a sample on an analytical test element, with the analysis system comprising a test element receptacle for receiving and positioning a test element in an analysis position. In an exemplary embodiment, the test element receptacle contains a guide part and a lock part, the guide part having means for guiding a test element into and out of the analysis position, the lock part comprising a frame and a bolt element, which frame and bolt element are connected to one another by a hinge. The bolt element can be pivoted about the hinge between a first position and a second position with respect to the frame. The bolt element comprises a latching lug for engaging in a recess in test element when the bolt element is in the first position and when the test element is positioned in the analysis position.

Abstract: A system for creating variable dimension digital documents. The system includes a computer processor and a computer readable medium operably connected to the computer processor and having at least one software module installed on the computer readable medium and containing instructions for operating the computer processor to perform a process. The process includes the steps of receiving a user defined goal for creating a variable dimension digital document, wherein the user defined goal includes at least one recipient, determining at least one document template based upon the user defined goal, determining a plurality of digital assets to include in the variable dimension digital document based upon the document template and the user defined goal, creating a plurality of data files representing the potential variable dimension digital documents, and producing a results set including the potential variable dimension digital documents.

Abstract: The invention relates to embodiments of an analysis system and to a method for analyzing a sample on an analytical test element, with the analysis system comprising a test element receptacle for receiving and positioning a test element in an analysis position. In an exemplary embodiment, the test element receptacle contains a guide part and a lock part, the guide part having means for guiding a test element into and out of the analysis position, the lock part comprising a frame and a bolt element, which frame and bolt element are connected to one another by a hinge. The bolt element can be pivoted about the hinge between a first position and a second position with respect to the frame. The bolt element comprises a latching lug for engaging in a recess in test element when the bolt element is in the first position and when the test element is positioned in the analysis position.

Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of a mammalian species, particularly humans.

Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of a mammalian species, particularly humans.

Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of a mammalian species, particularly humans.

Abstract: This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions related to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of a mammalian species, particularly humans.