Abstract: The present invention is related to pharmaceutical compositions for the inhibition of metastases and treatment of cancer such as bladder carcinoma, colon cancer, endometrial cancer, hepatocellular carcinoma, leukemia, lymphoma, melanoma, non-small cell lung cancer (NSCLC), ovarian cancer, pancreatic cancer, prostate cancer, soft tissue cancer, renal cancer, osteosarcoma, mesothelioma, myeloma multiple, bladder carcinoma and esophagcal cancer as well as the use of these pharmaceutical compositions for the treatment of said metastases and cancers. Another aspect of this invention are new antisense oligonucleotides inhibiting the formation of human interleukin 10 and their synthesis. A further aspect of this invention is the use IL-10 antisense oligonucleotides for the preparation of pharmaceutical compositions and for the treatment of cancer and metastases.

Abstract: A fault tolerant actuation system (12) for flight control systems is provided. The fault tolerant actuation system (12) includes a plurality of primary flight computers (14a, 14b, and 14c) with corresponding power control units (24a, 24b, and 24c). Each power control unit includes a remote electronic unit (18a, 18b, and 18c), an electro-hydraulic servo valve (26a, 26b, and 26c), and an actuator (28a, 28b, and 28c). The actuators are linked to a flight control surface (30) to control its position. The electro-hydraulic servo valves (26a, 26b, and 26c) and the actuators (28a, 28b, and 28c) include sensors that monitor their operation. Each RE (18a, 18b, and 18c) generates a control current (i.sub.1, i.sub.2, and i.sub.3) based upon commands of the corresponding primary flight computer as well as feedback data transmitted from the sensors of the corresponding electro-hydraulic servo valve and actuator only. The feedback data is transmitted along separate servo loops having separate compensations (66a, 70a).