Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol APLNR). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition.

Abstract: Embodiments herein relate to fenestrations exhibiting coastal impact performance. In an embodiment, a fenestration unit includes a frame assembly forming a first lower corner and a second lower corner. A first sill corner bracket can fit on a top of a sill and extend from the first lower corner partway along the top of the sill and partway along one side jamb of the frame assembly. A second sill corner bracket can be configured to fit on the top of the sill and extend from the second lower corner partway along the top of the sill and partway along the other side jamb. A bottom sash can include a bottom rail defining a channel to receive at least a portion of the first corner bracket and the second corner bracket therein when the bottom sash is in the closed position. Other embodiments are also included herein.

Abstract: Aspiration medical device as well as methods for making and using aspiration medical devices are disclosed. An example aspiration medical device may include a tubular member having a distal end region and defining an inflow orifice adjacent to the distal end region. An aspiration member may be disposed within the tubular member. The aspiration member may have a plurality of axially-spaced fluid jets formed therein.

Abstract: This disclosure relates to LPA antagonists of Formula (I): including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol “APLNR”). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition.

Abstract: Examples described herein relate to a securing sub-system. The securing sub-system includes a lever and a cam assembly engaged with the lever. The cam assembly is movable due to a pivotal movement of the lever and includes a cam body, a cantilevered arm, and a load support member. The cantilevered arm extends from the cam body and is deformable when the cantilevered arm contacts a restrictive structure. The load support member disposed on the insertion cam. A portion of the load support member is offset from an open end of the cantilevered arm to limit deformation of the cantilevered arm. Further, some examples described herein relate to a securing system including a plurality of securing sub-systems coupled via a synchronous movement link is also presented. Moreover, certain examples described herein relate to a computing system including at least one such securing sub-system.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol APLNR). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition.

Abstract: Embodiments herein relate to fenestrations, such as windows and doors, exhibiting coastal impact performance. In a first aspect, an impact-resistant fenestration unit can be included having a frame assembly including a sill, a head jamb, and two opposed side jambs. A bottom sash can be included having a bottom rail, a check rail, and two opposed stiles. A first corner key can be configured to engage the bottom sash at a first lower corner. The first corner key can include a support arm extending in a first direction onto or into a first stile of the two opposed stiles. A first reinforcement member disposed on or within the first stile. The first reinforcement member can include a first end and a second end. The first end can overlap a portion of the support arm of the first corner key. Other embodiments are also included herein.

Abstract: Embodiments herein relate to fenestrations exhibiting coastal impact performance. In an embodiment, a fenestration unit includes a frame assembly forming a first lower corner and a second lower corner. A first sill corner bracket can fit on a top of a sill and extend from the first lower corner partway along the top of the sill and partway along one side jamb of the frame assembly. A second sill corner bracket can be configured to fit on the top of the sill and extend from the second lower corner partway along the top of the sill and partway along the other side jamb. A bottom sash can include a bottom rail defining a channel to receive at least a portion of the first corner bracket and the second corner bracket therein when the bottom sash is in the closed position. Other embodiments are also included herein.

Abstract: Embodiments herein relate to fenestrations, such as windows and doors, exhibiting coastal impact performance. In a first aspect, an impact-resistant fenestration unit can be included having a frame and a bottom sash. The bottom sash can have a bottom rail, a check rail, and opposed stiles and can be configured to pivot inward away from the frame assembly such that the check rail moves away from the frame assembly. A first side bracket can define a cavity to receive a portion of a bolt from a sash tilt bolt assembly. The first side bracket can be mounted on one of the two opposed side jambs at a height corresponding to a position of the check rail when the bottom sash can be in a closed position. The bolt can include a metal inner support member and a polymeric overmold portion. Other embodiments are also included herein.

Abstract: A medical implant includes a body and a porous structure attached to the body. A boss integral with the body extends outwardly from a surface of the body. The porous structure has a surface that cooperates with the boss of the body to prevent pullout of the body from the porous structure. In fabricating the medical implant, the body and the porous structure are formed separately and subsequently secured together.

Abstract: A hybrid conductor puller-tensioner and control system are disclosed. The puller-tensioner includes a motor/generator mechanically coupled to a drum. The motor/generator is in electrical communication with a generator and a rechargeable power source. In a tensioning mode, the motor/generator can be used to charge the rechargeable power source. In a pulling mode, when the power demanded by the motor exceeds the capacity of the generator, the motor can be connected to both the generator and the rechargeable power source simultaneously to provide additional power.

Abstract: A system for converting a first joint prosthesis to a second joint prosthesis in-situ includes a plurality of inserts having a bone interface side and a component facing side and a plurality of articulating components having a cavity configured to receive at least one of the plurality of inserts. The plurality of inserts may be unicompartmental, bicompartmental, or tricompartmental. The inserts may be made of metal and may have a bone contacting surface made of a porous metal. The plurality of articulating components may be unicompartmental, bicompartmental, or tricompartmental. The articulating components may be sized and shaped to cover one or more of the plurality of bone interface components and span a distance therebetween. The articulating components may be made of a polymer.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor, gene symbol APLNR). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition.

Abstract: Examples described herein relate to a securing sub-system. The securing sub-system includes a lever and a cam assembly engaged with the lever. The cam assembly is movable due to a pivotal movement of the lever and includes a cam body, a cantilevered arm, and a load support member. The cantilevered arm extends from the cam body and is deformable when the cantilevered arm contacts a restrictive structure. The load support member disposed on the insertion cam. A portion of the load support member is offset from an open end of the cantilevered arm to limit deformation of the cantilevered arm. Further, some examples described herein relate to a securing system including a plurality of securing sub-systems coupled via a synchronous movement link is also presented. Moreover, certain examples described herein relate to a computing system including at least one such securing sub-system.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol APLNR). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition.

Abstract: A system for converting a first joint prosthesis to a second joint prosthesis in-situ includes a plurality of inserts having a bone interface side and a component facing side and a plurality of articulating components having a cavity configured to receive at least one of the plurality of inserts. The plurality of inserts may be unicompartmental, bicompartmental, or tricompartmental. The inserts may be made of metal and may have a bone contacting surface made of a porous metal. The plurality of articulating components may be unicompartmental, bicompartmental, or tricompartmental. The articulating components may be sized and shaped to cover one or more of the plurality of bone interface components and span a distance therebetween. The articulating components may be made of a polymer.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol “APLNR”). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition.

Abstract: A medical implant includes a body and a porous structure attached to the body. A boss integral with the body extends outwardly from a surface of the body. The porous structure has a surface that cooperates with the boss of the body to prevent pullout of the body from the porous structure. In fabricating the medical implant, the body and the porous structure are formed separately and subsequently secured together.

Abstract: A medical implant includes a body and a porous structure attached to the body. A boss integral with the body extends outwardly from a surface of the body. The porous structure has a surface that cooperates with the boss of the body to prevent pullout of the body from the porous structure. In fabricating the medical implant, the body and the porous structure are formed separately and subsequently secured together.