Abstract: A femoral head resurfacing implant includes a head having a rim separating an outer surface of the head from an inner surface of the head. The head has a shape such that a first plane extends through three separate locations along a length of a rim of the head. The implant also includes a stem extending from the inner surface of the head to a tip that is interior to an opening of the implant. Additionally, the stem is entirely on the first side of the first plane. The stem may be configured to be implanted within the natural bone of a patient at an angular offset designed to preserve the integrity of the preexisting bone structure.

Abstract: Disclosed herein, in certain embodiments, are anti-hCCR8 antibodies, anti-hCCR8 antibody conjugates, and pharmaceutical compositions which comprise the anti-hCCR8 antibodies or conjugates. In some embodiments, also disclosed herein are methods of delivering a payload utilizing an anti-hCCR8 antibody described herein, and methods of treatment with use of an anti-hCCR8 antibody described herein.

Abstract: An integrated platform system that employ a series of machine learning techniques and prediction and detection units that can process input data and extract and generate meaningful insights and predictions therefrom. The system integrates together multiple different data storage types and applications that generates data of different types, and an associated processing system for processing the different data types, store the data in a common data model to normalize the data, determine the data lineage of the data, and then process the data using different types of techniques. The data can also be processed by a prediction unit for generating meaningful insights and predictions or by an anomaly detection unit for detecting one or more anomalies in the data.

Abstract: A disclosed server system for dynamically generating and serving content for presentation across different channels can perform the following operations: receive a request from a client device for a subset of content elements, the request designating a desired channel for presenting content in a page, identify the subset having at least one content attribute that satisfies one or more subset creation criteria indicating a category identifier for a slot in a page template used for generating the page, dynamically generate the subset by: for each content element in the subset, dynamically adjusting presentation of the singular instance of the content element based on presentation requirements of the desired channel, the singular instance being commonly used across all device interface types, and serve the subset of the content elements to the client device, which includes the singular instances of the content elements dynamically adjusted for presentation in the desired channel.

Abstract: The present disclosure pertains to injectable shear-thinning compositions that comprise (a) one or more types of fibrous proteins, (b) one or more types of silicate microparticles, (c) one or more types of radiopaque additives, (d) one or more types of cryoprotectants, and (e) water. Other aspects of the present disclosure pertain to kits that contains such compositions and medical procedures that comprise administering such compositions to a patient.

Abstract: Machine learning-based methods are disclosed to intelligently generate dynamic workflows, such as dynamic call lists and priority levels of alarm notifications. To generate a dynamic call list based on an alarm notification, the system may identify electronic devices present in an area using emitted passive electromagnetic signals (e.g., RF signals such as Bluetooth, WiFi, and/or cellular). The identification of the electronic devices may be associated with known and/or unknown individuals on the premises. The RF signal data may be processed using at least one ML model to determine the severity of the alarm. Based on the processed data, the system may assign a priority level to the alarm, where the priority level may range from level 0 (no action) to level 4 (dispatch law enforcement immediately). The disclosed methods use trained machine learning models to generate a dynamic call list and identify false alarms with increased accuracy.

Abstract: The disclosed technology includes an air moving system for a stringing apparatus. The air moving system can comprise an energy bank, an electric air moving device in electrical communication with the energy bank and configured to output a supply of air to cause a cable to move along a duct and at least one controller. The at least one controller can be configured to determine a speed of the cable moving along the duct and control the output of the supply of air of the electric air moving device to control the speed of the cable based at least in part on the determined speed of the cable.

Abstract: In some embodiments, the present disclosure pertains to an injectable shear-thinning composition that comprises (a) one or more types of polymers, (b) one or more types of microparticles and (c) water. In some embodiments, the present disclosure pertains to a kit that comprises (a) one or more containers that contain an injectable shear-thinning composition that comprises one or more types of polymers, one or more types of microparticles and water and (b) a delivery device. In some embodiments, the present disclosure pertains to a medical procedure comprising administering to a subject an injectable shear-thinning composition that comprises one or more types of polymers, one or more types of microparticles and water.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol “APLNR”). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition.

Abstract: Aqueous liquid embolic compositions, for example formed from amino acids, as well as method for making and using aqueous liquid embolic compositions are disclosed. An example aqueous liquid embolic composition may include a di-block or tri-block copolymer including a charged block and a hydrophobic block. The aqueous liquid embolic composition may also include templating agent.

Abstract: Aqueous liquid embolic compositions as well as method for making and using aqueous liquid embolic compositions are disclosed. An example aqueous liquid embolic composition may include a di-block or tri-block copolymer including a hydrophobic monomer block and a charged (polycationic or polyanionic) block. The charged (polycationic or polyanionic) block may include one or more anions. The aqueous liquid embolic composition may also include templating agent.

Abstract: Medical systems are described, including a medical system that includes a sheath and a catheter. The sheath is configured to be positioned within a urethra of a patient. A proximal portion of the sheath includes a port configured to receive one or more fluids. The catheter is insertable into the sheath and configured to be movably positioned within the sheath in the urethra. A distal portion of the catheter includes one or more ultrasound transducers configured to perform ultrasound imaging of at least a portion of a prostate of the patient.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol APLNR). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition.

Abstract: Embodiments herein relate to fenestrations exhibiting coastal impact performance. In an embodiment, a fenestration unit includes a frame assembly forming a first lower corner and a second lower corner. A first sill corner bracket can fit on a top of a sill and extend from the first lower corner partway along the top of the sill and partway along one side jamb of the frame assembly. A second sill corner bracket can be configured to fit on the top of the sill and extend from the second lower corner partway along the top of the sill and partway along the other side jamb. A bottom sash can include a bottom rail defining a channel to receive at least a portion of the first corner bracket and the second corner bracket therein when the bottom sash is in the closed position. Other embodiments are also included herein.

Abstract: This disclosure relates to LPA antagonists of Formula (I): including pharmaceutically acceptable salts and solvates thereof, and pharmaceutical compositions including the same.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol “APLNR”). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition.

Abstract: Examples described herein relate to a securing sub-system. The securing sub-system includes a lever and a cam assembly engaged with the lever. The cam assembly is movable due to a pivotal movement of the lever and includes a cam body, a cantilevered arm, and a load support member. The cantilevered arm extends from the cam body and is deformable when the cantilevered arm contacts a restrictive structure. The load support member disposed on the insertion cam. A portion of the load support member is offset from an open end of the cantilevered arm to limit deformation of the cantilevered arm. Further, some examples described herein relate to a securing system including a plurality of securing sub-systems coupled via a synchronous movement link is also presented. Moreover, certain examples described herein relate to a computing system including at least one such securing sub-system.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize) the apelin receptor (also referred to herein as the APJ receptor; gene symbol APLNR). This disclosure also features compositions containing the same as well as other methods of using and making the same. The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which a decrease in APJ receptor activity (e.g., repressed or impaired APJ receptor signaling; e.g., repressed or impaired apelin-APJ receptor signaling) or downregulation of endogenous apelin contributes to the pathology and/or symptoms and/or progression of the disease, disorder, or condition.

Abstract: Embodiments herein relate to fenestrations, such as windows and doors, exhibiting coastal impact performance. In a first aspect, an impact-resistant fenestration unit can be included having a frame assembly including a sill, a head jamb, and two opposed side jambs. A bottom sash can be included having a bottom rail, a check rail, and two opposed stiles. A first corner key can be configured to engage the bottom sash at a first lower corner. The first corner key can include a support arm extending in a first direction onto or into a first stile of the two opposed stiles. A first reinforcement member disposed on or within the first stile. The first reinforcement member can include a first end and a second end. The first end can overlap a portion of the support arm of the first corner key. Other embodiments are also included herein.

Abstract: Embodiments herein relate to fenestrations, such as windows and doors, exhibiting coastal impact performance. In a first aspect, an impact-resistant fenestration unit can be included having a frame and a bottom sash. The bottom sash can have a bottom rail, a check rail, and opposed stiles and can be configured to pivot inward away from the frame assembly such that the check rail moves away from the frame assembly. A first side bracket can define a cavity to receive a portion of a bolt from a sash tilt bolt assembly. The first side bracket can be mounted on one of the two opposed side jambs at a height corresponding to a position of the check rail when the bottom sash can be in a closed position. The bolt can include a metal inner support member and a polymeric overmold portion. Other embodiments are also included herein.