Abstract: The field of the present invention pertains to a controlled transfer biological collection device using a dry solid storage and transfer medium and a method for the collection of biological material of interest (genetic or proteinaceous material) in a form suitable for storage and/or subsequent analysis. Specifically, the present invention provides for a sampling device that controls the transfer of the biological sample to the storage medium by holding the storage medium and a moveable sample collection member having an analyte collection surface. The invention further provides for a method not only for storing a biological analyte on this collection device but also for analyzing the stored biological analyte using methods that are suited for automated analyzing systems.

Abstract: A data management system for managing the storage of data on primary and secondary storage from a primary information source having original file content to be stored including: a data file stub stored on primary storage; a data file stored on secondary storage; and wherein: the data file stub comprises original file meta data and additional stub meta data relevant to the data file; the data file comprises the original file content and additional file meta data relevant to the data file stub; the additional stub meta data includes location and information relevant to locate and recover the data file; the additional file meta data includes information relevant to the location and content of the stub; the additional stub meta data and additional file meta data being so formed and arranged that the data to be stored may be accessed without stateful middleware.

Abstract: A method of producing a silica or silica-like coating by forming a precursor formulation from oligomeric organosilicate. The precursor formulation is coated on a substrate as a continuous liquid phase. The precursor formulation is then cured in an ammoniacal atmosphere to produce a continuous, interconnected, nano-porous silica network.

Abstract: A user annotates a shared document with text, sound, images, video, an e-mail message, graphics, screen snapshots, web site snapshots to share with others. The document and its annotations are stored in a digital object repository to which other users have access. Within the closed collaboration system, only users who are authenticated may upload digital objects, annotate digital objects and view objects and their annotations. The user sends a message to other users to invite them to view the object and its annotations and to add their own annotations. An annotated object generates an alert for all of the invited users. A remote authentication gateway authenticates users and has a repository for user metadata. Digital object repositories are separate from the authentication gateway, thus providing for disintermediation of the user metadata from the digital object data. The collaboration system may be hosted by a third party on a server computer available over the Internet that displays a web site.

Abstract: A formation isolation valve for underbalanced drilling applications. A system for operating a formation isolation valve includes the valve interconnected in a casing string. An assembly displaces through the casing string, thereby causing the valve to open prior to the assembly reaching the valve. An operating system includes a well tool with an actuator positioned downhole. A device for causing the actuator to operate the well tool is also positioned downhole remote from the actuator. A method of operating a well tool includes the steps of: positioning the well tool in a well, the well tool including an actuator; positioning a power source for the actuator in the well; and at a downhole position remote from the actuator, causing the actuator to operate the well tool.

Abstract: Use of a compound for the manufacture of a medicament for use in therapy of a neurodegenerative condition, wherein the compound is of formula (I): wherein R1 is CHR4—OR5 or CHR4—SR5, or aryl or heteroaryi optionally substituted with one or more groups R6; R2 is alkyl or is part of a ring with R3; R3 is H, alkyl or CH2 (when forming part of a ring with R2); R4 is H or alkyl or is part of a ring with R5; R5 is aryl or heteroaryi optionally substituted with R7; each R6 is independently alkyl, CF3, OH, Oalkyl, OCOalkyl, CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHSO2alkyl, CONH2, SOMe, SO2NH2, Salkyl, CH2SO2alkyl or OCONalkyl2; R7 is R8 or (CH2)nOR8, R9, CF3, OH, OR9, OCOR9, COR9, COOR9, CONH2, CH2CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHCONHR7, NHCON(R9)2, NHCOR9, NHCOaryl, NHSO2Me, CONH2, SMe, SOMe or SO2NH2; R8 is (CH2)nOR9, (CH)nOR9, (CH2)nCOOR9 or (CH2)nCOaryl; R9 is alkyl or cycloalkyl; and n is 1 to 4; or a salt thereof.

Abstract: The present invention relates to crystalline forms of ECO-4601 and the processes for providing them. The invention further relates to pharmaceutical compositions comprising the crystalline forms and to methods of use of the crystalline forms as pharmaceuticals.

Abstract: An imaging and display system provides helicopter pilots with an unobstructed display of a landing area in a brownout or whiteout condition by capturing a high resolution image of the landing area prior to obscuration. Using inertial navigation information from the aircraft or an independent system, the system transforms the image to a desired viewpoint and overlays a representation of the helicopter's current position relative to the landing area. The system thus greatly improves orientation and situational awareness, permitting safe and effective operation under zero visibility brownout conditions.

Abstract: A system and method for removing water from a liquid desiccant such as a glycol used to dry cooled air in order to restore the desiccant to a purity up to around 97% in a closed continuous flow process. Liquid desiccant can be sprayed into cooled air in a conditioner where it gains moisture. The wet or gained desiccant can be optionally preheated in an economizing heat exchanger and then routed into a concentrator. Desiccant pure to around 97% can be removed from the concentrator, passed through an economizing heat exchanger to provide the preheating and returned to the conditioner holding area. The concentrator can be heated by steam or other means such as natural gas to boil the wet desiccant causing mixed vapor to enter a vertical distillation column where most of the glycol condenses out on the column packing or plates and returns to the concentrator.

Abstract: An airfoil is disclosed having a concave pressure side and a convex suction side defining a chord length, and a leading edge and a trailing edge. A leading edge protective strip is adhered by a bond layer to and protectively covers the leading edge and respective predetermined portions of the pressure side and suction side of the airfoil body from the leading edge downstream towards the trailing edge. The leading edge protective strip includes a multiplicity of inwardly-facing grooves in which the bond layer is embedded. The grooves define adjacent segments of a predetermined size sufficiently small that, if detached from the vane during engine operation, impact with downstream engine components will not cause damage to the downstream engine components.

Abstract: An airfoil is disclosed having a concave pressure side and a convex suction side defining a chord length, and a leading edge and a trailing edge. A leading edge protective strip is adhered by a bond layer to and protectively covers the leading edge and respective predetermined portions of the pressure side and suction side of the airfoil body from the leading edge downstream towards the trailing edge. The predetermined portion of the suction side covered by the leading edge protective strip is less than the predetermined portion of the pressure side covered by the leading edge protective strip.

Abstract: A compound that is useful for the treatment or prevention of a condition such as pain, that is associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines, is of formula (I) wherein R1 is aryl or heteroaryl optionally substituted with R5; R2 is H, alkyl or CH2OH and can be part of a ring with R4; R3 is H, alkyl or CH2OH and can be part of a ring with R4; R4 is H or alkyl or CH2 (when forming part of a ring with R2 or R3); and R5 is alkyl, CF3, OH, Oalkyl, OCOalkyl, CONH2, CN, F, Cl, Br, I, NH2, NHCHO, NHCONH2, NHSO2alkyl, CONH2, SOMe, CH2OH or OCONalkyl2; or a salt thereof.

Abstract: A method of controlling the morphology of silica or silica-like films formed by coating a precursor formulation of hydrolysable silicate oligomer onto a substrate and curing in a vapourous environment that comprises a base, water and a retarder that retards the hydrolysis of the oligomer.

Abstract: Nefopam or an analogue thereof is useful in the treatment of a syndrome characterized by chronic pain and fatigue.

Abstract: The field of the present invention pertains to a controlled transfer biological collection device using a dry solid storage and transfer medium and a method for the collection of biological material of interest (genetic or proteinaceous material) in a form suitable for storage and/or subsequent analysis. Specifically, the present invention provides for a sampling device that controls the transfer of the biological sample to the storage medium by holding the storage medium and a moveable sample collection member having an analyte collection surface. The invention further provides for a method not only for storing a biological analyte on this collection device but also for analyzing the stored biological analyte using methods that are suited for automated analyzing systems.

Abstract: In one aspect, a method for assembling a rotor assembly is provided. The method comprises providing a rotor blade including a first sidewall, a second sidewall, where the first and second sidewalls are connected at a leading edge and a trailing edge and extend in span from a root portion to a tip portion, removing blade material from the tip portion to form a tip portion rake angle that enables the tip portion to extend obliquely between the first and second sidewalls, and coupling the rotor blade to a shaft such that during tip rubs the tip portion rake angle facilitates reducing radial loading induced to the blade during tip rubs.

Abstract: The invention includes convenient methods of preparing: (1) highly concentrated liquid bromine-containing biocidal solutions, (2) highly concentrated mixed halogen liquid bromine and chlorine-containing biocidal solutions, and (3) high-activity bromine-containing biocidal solids, all having excellent physical and chemical stability. One method yields solutions that have concentrations of bromine in excess of 18% as Br2 (8% as Cl2) in which the mole ratio of hydroxide ion to hydrogen ion source is at least 1.9:1. Another method employs elemental bromine in conjunction with a solid organic or inorganic halogenating agent to yield halogen solutions at concentrations greater than 22.9% as Br2 (10.2% as Cl2). This method can be performed under conditions that exceed the solubility of the active ingredient such that it crystallizes and is recovered as a hydrated or anhydrous salt in good yield.

Abstract: A method for improving a downlink signal received by a listener on a phone is disclosed. The method includes calculating an environment noise level of the listener and filtering and adjusting gain of the downlink signal based on the environment noise level.

Abstract: A locking mechanism including a first engagement element movable from a disengaged position to an engageable position upon receipt of a controlled predetermined electrical power input and a manually operated element engageable with said engagement element in said engageable position thereof. A lock bolt is mounted for movement between a locking position and an unlocking position. A lock-bolt drive element is operatively coupled with the lock bolt and is engageable with said manually operated element to move the lock-bolt between the unlocking and locking positions and a control is operable to supply the controlled predetermined electrical power input.

Abstract: A self-powered electric lock includes a lock bolt and a first engagement element having disengaged and engageable positions. An electric actuator includes an output operative to move the first engagement element to its engageable position. A manually operated rotatable member is operatively coupled to the first engagement element when the first engagement element is in its engageable position. A lock bolt drive mechanism is coupled to the lock bolt and to the first engagement element when the first engagement element is in its engageable position. The movable output moves the first engagement element to its engageable position upon input of correct electronic data. An electricity generator is coupled to the manually operated rotatable member. The electricity powers the electric actuator and an electronic data input device. The manually operated rotatable member is also used to actuate the lock bolt drive mechanism and retract the lock bolt.