Patents by Inventor Michael A. Helmrath

Michael A. Helmrath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230365941
    Abstract: Disclosed herein are organoid compositions having heterogeneous combinations of epithelial and mesenchymal components, and methods of making the same by dissociating and recombining the epithelial and mesenchymal components from different sources. These epithelial and mesenchymal components can be derived from the same or different cell type or organoid type. These organoid compositions may exhibit advantageous properties, for example, enhanced in vivo engraftment.
    Type: Application
    Filed: September 29, 2021
    Publication date: November 16, 2023
    Inventors: Michael A. Helmrath, Simon Vales, Nambirajan Sundaram, Akaljot Singh, Nicole Brown
  • Patent number: 11584916
    Abstract: Disclosed are methods for making a vascularized hollow organ derived from human intestinal organoid (HIOs). The HIOs may be obtained from human embryonic stem cells (ESC's) and/or induced pluripotent stem cells (iPSCs), such that the HIO forms mature intestinal tissue. Also disclosed are methods for making a human intestinal tissue containing a functional enteric nervous system (ENS).
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: February 21, 2023
    Assignee: Children's Hospital Medical Center
    Inventors: James M. Wells, Carey Lane Watson, Jorge Orlando Munera, Maxime Mickael Mahe, Michael A. Helmrath, Michael J. Workman
  • Publication number: 20220243179
    Abstract: Disclosed herein are organoid compositions that are manipulated to form shaped or elongated morphologies that more closely resemble native organ structures. These shaped organoids are advantageous for purposes such as studying organellar organization and for transplants compared to unformed organoids. Also disclosed herein are methods of producing said shaped or elongated organoid compositions.
    Type: Application
    Filed: May 29, 2020
    Publication date: August 4, 2022
    Inventors: Michael A. Helmrath, Maxime Mickael Mahe, Holly M. Poling
  • Patent number: 11376117
    Abstract: Various aspects of the disclosure relate to a tracheal implant comprising (a) a trachea processed to comprise one or more incisions providing a helical configuration to the processed trachea; and (b) a subject-specific synthetic support.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: July 5, 2022
    Assignees: University of Cincinnati, Children's Hospital Medical Center
    Inventors: Chia-Ying James Lin, John van Aalst, Stacey Gruber, Alessandro de Alarcon, Michael A. Helmrath
  • Publication number: 20210115366
    Abstract: Disclosed herein are methods of enhancing development of a three-dimensional in vitro model of an intestinal tissue (HIO), which may be derived from a precursor cell. The precursor cell may be, for example, an embryonic stem cell, an induced pluripotent stem cell (iPSC), or the like. The in vitro HIO model may be characterized in that the HIO has a lumen, in which a lengthening device may be inserted to promote development of the HIO. Compositions derived from the disclosed methods are also described.
    Type: Application
    Filed: April 24, 2018
    Publication date: April 22, 2021
    Inventors: Maxime Mickael Mahe, Michael A. Helmrath, Holly M. Poling, James Wells
  • Patent number: 10857167
    Abstract: Provided herein are compositions and methods related to use of oligosaccharides, such as 2?-fucosyllactose, for increasing weight gain in a subject. In some aspects the compositions and methods are for use in infants, such as premature infants or infants having intestinal failure.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: December 8, 2020
    Assignee: CHILDREN'S HOSPITAL MEDICAL CENTER
    Inventors: Ardythe L. Morrow, Michael A. Helmrath, Ethan Mezoff
  • Publication number: 20200253727
    Abstract: Various aspects of the disclosure relate to a tracheal implant comprising (a) a trachea processed to comprise one or more incisions providing a helical configuration to the processed trachea; and (b) a subject-specific synthetic support.
    Type: Application
    Filed: August 31, 2018
    Publication date: August 13, 2020
    Inventors: Chia-Ying James Lin, John van Aalst, Stacey Gruber, Alessandro de Alarcon, Michael A. Helmrath
  • Publication number: 20180153915
    Abstract: Provided herein are compositions and methods related to use of oligosaccharides, such as 2?-fucosyllactose, for increasing weight gain in a subject. In some aspects the compositions and methods are for use in infants, such as premature infants or infants having intestinal failure.
    Type: Application
    Filed: April 28, 2016
    Publication date: June 7, 2018
    Applicant: Children's Hospital Medical Center
    Inventors: Ardythe L. MORROW, Michael A. HELMRATH, Ethan MEZOFF
  • Publication number: 20170292116
    Abstract: Disclosed are methods for making a vascularized hollow organ derived from human intestinal organoid (HIOs). The HIOs may be obtained from human embryonic stem cells (ESC's) and/or induced pluripotent stem cells (iPSCs), such that the HIO forms mature intestinal tissue. Also disclosed are methods for making a human intestinal tissue containing a functional enteric nervous system (ENS).
    Type: Application
    Filed: October 16, 2015
    Publication date: October 12, 2017
    Inventors: James M. Wells, Carey Lane Watson, Jorge Orlando Munera, Maxime Mickael Mahe, Michael A. Helmrath, Michael J. Workman