Abstract: The present invention provides N-methylated cyclic hexapeptides comprising RGD and at least one alanine residue. The present invention further provides prodrugs comprising the cyclic hexapeptides. Pharmaceutical compositions comprising said cyclic hexapeptides are also disclosed as well as methods of their production and use in treating integrin related conditions and diseases.

Abstract: The present subject matter relates to a radar system for detecting the surroundings of a moving object, in particular a vehicle and/or a transport device, such as in particular a crane, wherein the system is mounted or mountable on the moving object, wherein the radar system comprises at least one first, non-coherent, and at least one second, non-coherent, radar module with at least one antenna, wherein the radar modules are arranged or can be arranged distributed on the moving object, wherein at least one first radar module is configured differently from at least one second radar module.

Abstract: The disclosed embodiments include a system and method for generating a predictive model for determining whether a reamer has experienced significant wear. The system includes an information acquisition processor and a server. The information acquisition processor retrieves wellbore information, transmits the information to the server.

Abstract: The present invention relates to a suspension for coating of medical devices containing at least one tri-O-acylglycerol, at least one taxane in the form of microcrystals and at least one solvent in which the at least one tri-O-acylglycerol dissolves and in which the microcrystals of the at least one taxane do not dissolve. Furthermore, the present invention relates to a p method for preparing said suspension, a p method for coating a medical device with said suspension, and medical devices coated with at least one tri-O-acylglycerol and at least one microcrystalline taxane.

Abstract: The invention relates to barcoded nucleic acid nanostructure delivery compositions for in vivo screening for subsequent use in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to nucleic acid nanostructure delivery compositions, such as DNA origami structures, associated with barcodes for high throughput in vivo screening of the nucleic acid nanostructure delivery compositions for subsequent use in drug delivery, and methods therefor.

Abstract: A surface cleaner configured to distribute a liquid to a surface to be cleaned. The surface cleaner includes a supply tank, a fluid distributor, a suction inlet aperture, a recovery tank and a tool removably connectable to the surface cleaner and configured to direct fluid from the fluid distributor into the suction inlet aperture to rinse the suction inlet aperture.

Abstract: A system, method and apparatus for remote control of a thermostat by a network-based server, when the thermostat is not connected to a local or wide-area network. A network-based server calculates a modified temperature profile for a thermostat based on a utility's time-of-use pricing and/or weather forecasts. After the server has calculated the modified temperature profile, it is provided to a mobile device via a wide-area network, and the mobile device provides the modified temperature profile directly to the thermostat when the mobile device is within range of the thermostat.

Abstract: The present invention relates to a suspension for coating of medical devices containing at least one tri-O-acylglycerol, at least one limus active agent in the form of microcrystals and at least one solvent in which the at least one tri-O-acylglycerol dissolves and in which the microcrystals of the at least one limus active agent do not dissolve. Furthermore, the present invention relates to a pmethod for preparing said suspension, a p method for coating a medical device with said suspension, and medical devices coated with at least one tri-O-acylglycerol and at least one microcrystalline limus active agent.

Abstract: Systems and methods are described for a media guidance application (e.g., implemented on a user device) that manages user subscriptions to content sources by modifying content source bundles to tailor them toward user preferences.

Abstract: In a jet engine having a core that sources a first flow of fluid and a component (such as a fan, a pump, and/or a bleed line) that sources a second flow of fluid, and where the first flow of fluid will typically have, at least during ordinary operation, a higher temperature than the second flow of fluid, at least one flow aperture formed by a first passageway to receive at least a portion of the aforementioned second flow of fluid, wherein that first passageway is comprised of at least one material that (by design and intent) deflects as a function of temperature such that a flow of the second flow of fluid through the at least one flow aperture is thereby desirably modulated.

Abstract: Systems and associated methods are described for providing content recommendations. The system accesses content item consumption data for a plurality of users subscribed to a media service. Then, the system determines that a first subset of the plurality of users has unsubscribed from the media service and that a second subset of the plurality of users has not unsubscribed from the media service. The system identifies a time slot typical for the first subset of users and atypical for the second subset of users based on content item consumption data of the first subset of users and content item consumption data of the second subset of users. In response to determining that a user is consuming a first content item at the identified time slot, the system generates for display a recommendation for a second content item that is scheduled for a different time slot.

Abstract: A system, method and apparatus for remote control of a thermostat by a network-based server, when the thermostat is not connected to a local or wide-area network. A network-based server calculates a modified temperature profile for a thermostat based on a utility's time-of-use pricing and/or weather forecasts. After the server has calculated the modified temperature profile, it is provided to a mobile device via a wide-area network, and the mobile device provides the modified temperature profile directly to the thermostat when the mobile device is within range of the thermostat.

Abstract: Systems and methods are described for a media guidance application (e.g., implemented on a user device) that manages user subscriptions to content sources by modifying content source bundles to tailor them toward user preferences.

Abstract: A suture implant for approximating tissue without tying knots includes a suture having a first end with a fixed knot, a second end, and a slip knot located between the first and second ends, which defines a large suture loop having a length. The slip knot defines a dynamic end of the large suture loop that is located opposite a closed end of the large suture loop. A tissue anchor is coupled with the first end of the suture. Pulling the second end of the large suture loop away from the slip knot slides the slip knot and the tissue anchor toward the closed end of the large suture loop and reduces the length of the large suture loop. The suture implant includes a needle having a leading end and a trailing end and a small suture loop secured to the trailing end of the needle that is coupled with the closed end of the large suture loop.

Abstract: Systems and associated methods are described for providing content recommendations. The system accesses content item consumption data for a plurality of users subscribed to a media service. Then, the system determines that a first subset of the plurality of users has unsubscribed from the media service and that a second subset of the plurality of users has not unsubscribed from the media service. The system identifies a time slot typical for the first subset of users and atypical for the second subset of users based on content item consumption data of the first subset of users and content item consumption data of the second subset of users. In response to determining that a user is consuming a first content item at the identified time slot, the system generates for display a recommendation for a second content item that is scheduled for a different time slot.

Abstract: An implantable prosthetic device, such as a breast implant, includes a shell made of a biocompatible elastomeric material. The shell has a front portion and a base that surround an interior volume of the shell. A scaffold is disposed within the interior volume of the shell. The scaffold has an inner surface facing the base and an outer surface facing the front portion of the shell. A silicone gel is disposed within the interior volume of the shell. The scaffold has a shape that mirrors the shape of the front portion of the shell. The scaffold reinforces the shell to provide form stability for maintaining the shape of the shell and minimizing folding, dimpling and/or wrinkling of the shell. A second scaffold may be nested within the first scaffold. The second scaffold has a smaller outer dimension than an inner dimension of the first scaffold.

Abstract: An implantable prosthetic device, such as a breast implant, includes a shell made of a biocompatible elastomeric material. The shell has a front portion and a base that surround an interior volume of the shell. A scaffold is disposed within the interior volume of the shell. The scaffold has an inner surface facing the base and an outer surface facing the front portion of the shell. A biocompatible filler material, such as a silicone gel, is disposed within the interior volume of the shell. The scaffold has a shape that mirrors the shape of the front portion of the shell. The scaffold reinforces the shell to provide form stability for maintaining the shape of the shell and minimizing folding, dimpling and/or wrinkling of the shell. The scaffold has one or more openings formed therein for allowing the biocompatible filler material to fill the one or more openings. A second scaffold may be nested within the first scaffold.

Abstract: A test fixture for mechanically testing breast implants includes a frame, a base plate coupled with the frame, and a first actuator coupled with the base plate for providing reciprocating motion to the base plate along a first axis. The test fixture includes a compression plate coupled with the frame that opposes the base plate, a second actuator coupled with the compression plate for providing reciprocating motion to the compression plate along a second axis that intersects the first axis, and a third actuator coupled with the compression plate for providing reciprocating motion to the compression plate along a third axis that intersects both the first axis and the second axis. The test fixture includes a control system in communication with the first, second, and third actuators for controlling the movement of the base plate along the first axis and the movement of the compression plate along the second and third axes.

Abstract: In a jet engine having a core that sources a first flow of fluid and a component (such as a fan, a pump, and/or a bleed line) that sources a second flow of fluid, and where the first flow of fluid will typically have, at least during ordinary operation, a higher temperature than the second flow of fluid, at least one flow aperture formed by a first passageway to receive at least a portion of the aforementioned second flow of fluid, wherein that first passageway is comprised of at least one material that (by design and intent) deflects as a function of temperature such that a flow of the second flow of fluid through the at least one flow aperture is thereby desirably modulated.