Abstract: Described are antibiotic compositions effective against Gram-negative bacteria, the compositions comprising a polymyxin in combination with a tunicamycin or a modified tunicamycin, optionally in combination with a ?-lactam antibiotic. Use of these compositions to kill or inhibit Gram-negative bacteria, treat Gram-negative bacterial infections, or disinfect objects or surfaces are described.

Abstract: The invention relates to new tunicamycin structures comprising N-acyl groups metabolically integrated into the terminus of the TUN via the Streptomyces branched chain fatty acid pathways and variants thereof, and methods of preparing such new tunicamycin structures. The invention further relates to antibacterial compositions comprising such new tunicamycin structures, and methods for using such antibacterial compositions for killing Gram-positive bacteria.

Abstract: Disclosed are plasticizer compositions in the form of crop-based secondary amines prepared through catalyzed reductive amination (RA) of furans with aminated ketones. Exemplary furans include, but are not limited to, furfural, 5-(hydroxymethyl) furfural (HMF), and 2,5-diformylfuran (DFF). These furans may be crop-based. Furfural, for example, may be made through dehydration of xylose isolated from corn cobs. Exemplary aminated ketones include, but are not limited to, crop-based aminated ketones such as 2-aminoundecane. For example, 2-aminoundecane may be prepared through catalyzed RA of 2-undecanone from the seed oil of Cuphea. These RA reactions may be catalyzed using, for example, Pd/C. In some embodiments, the plasticizer compositions function as plasticizers when blended with polyvinylchloride (PVC) and/or other polymers to form plasticized compositions. Processes for making the plasticizer compositions and plasticized compositions are also disclosed.

Abstract: The disclosure provides stable aqueous formulations comprising an antibiotic and sodium deoxycholate (DOC), and optionally further comprising at least one carrier and/or excipient. The disclosure also provides methods for preparing such aqueous formulations, and methods for using such aqueous formulations to treat, attenuate, or prevent bacterial infection in a subject.

Abstract: The invention relates to new tunicamycin structures comprising N-acyl groups metabolically integrated into the terminus of the TUN via the Streptomyces branched chain fatty acid pathways and variants thereof, and methods of preparing such new tunicamycin structures. The invention further relates to antibacterial compositions comprising such new tunicamycin structures, and methods for using such antibacterial compositions for killing Gram-positive bacteria.

Abstract: Disclosed are C-glycoside amine derivatives of the formula: R—CH2—C(CH3)—NH—R2 wherein R is a saccharide (e.g., as described in U.S. Pat. No. 8,314,219) and R2 is an acyl moiety derived from any ketone of the formula R3—C(O)—R3 wherein R3 is C1 to C22 straight or branched chain hydrocarbon which may be saturated or unsaturated. In addition, a method for making the C-glycoside amine derivatives involving (1) reacting a saccharide (e.g., glucose) C-glycoside ketone with a catalyst (e.g., Rh), about 10 to about 25 fold excess NH3, and an organic solvent (e.g., methanol) to form a saccharide C-glycoside amine, and (2) reacting said saccharide C-glycoside amine with a catalyst (e.g., Rh), an organic solvent (e.g., methanol), and an acyl moiety derived from any ketone of the formula R3—C(O)—R3 wherein R3 is C1 to C22 straight or branched chain hydrocarbon which may be saturated or unsaturated to form said C-glycoside amine derivative.

Abstract: Disclosed are C-glycoside amine derivatives of the formula: R—CH2—C(CH3)—NH—R2 wherein R is a saccharide (e.g., as described in U.S. Pat. No. 8,314,219) and R2 is an acyl moiety derived from any ketone of the formula R3—C(O)—R3 wherein R3 is C1 to C22 straight or branched chain hydrocarbon which may be saturated or unsaturated. In addition, a method for making the C-glycoside amine derivatives involving (1) reacting a saccharide (e.g., glucose) C-glycoside ketone with a catalyst (e.g., Rh), about 10 to about 25 fold excess NH3, and an organic solvent (e.g., methanol) to form a saccharide C-glycoside amine, and (2) reacting said saccharide C-glycoside amine with a catalyst (e.g., Rh), an organic solvent (e.g., methanol), and an acyl moiety derived from any ketone of the formula R3—C(O)—R3 wherein R3 is C1 to C22 straight or branched chain hydrocarbon which may be saturated or unsaturated to form said C-glycoside amine derivative.

Abstract: Ketones may be produced in high yields from glycerides of short chain fatty acids by reaction with a carboxylic acid. The reaction is conducted in the presence of a catalyst and under conditions effective for ketonization of decanoate with the carboxylic acid to produce free ketones. Reaction of a glyceride comprising at least one ester of decanoic acid with a carboxylic acid selected from acetic acid and/or propionic acid produces 2-undecanone and/or 3-dodecanone, respectively. Catalysts of the formula FemCenAlpOx, wherein m is between about 0.2 to about 0.6, n is about 0.2, p is between about 0.6 to about 0.2, and x is greater than 0, produce significantly higher yields of the ketones than other known metal oxides.

Abstract: Ketones may be produced in high yields from glycerides of short chain fatty acids by reaction with a carboxylic acid. The reaction is conducted in the presence of a catalyst and under conditions effective for ketonization of decanoate with the carboxylic acid to produce free ketones. Reaction of a glyceride comprising at least one ester of decanoic acid with a carboxylic acid selected from acetic acid and/or propionic acid produces 2-undecanone and/or 3-dodecanone, respectively. Catalysts of the formula FemCenAlpOx, wherein m is between about 0.2 to about 0.6, n is about 0.2, p is between about 0.6 to about 0.2, and x is greater than 0, produce significantly higher yields of the ketones than other known metal oxides.

Abstract: A distributed features system is disclosed which permits a telecommunication network to accommodate the creation of open multimedia services. It is an object of the present invention to create an architecture that facilitates modularity and compositional service creation. It is another object of the present invention to support multimedia services, e.g. services that include voice, graphics, video and text components. It is another object of the present invention to provide an architecture that is general, flexible, permits third party feature development, and can interact with other networks.

Abstract: A distributed features system is disclosed which permits a telecommunication network to accommodate the creation of open multimedia services. It is an object of the present invention to create an architecture that facilitates modularity and compositional service creation. It is another object of the present invention to support multimedia services, e.g. services that include voice, graphics, video and text components. It is another object of the present invention to provide an architecture that is general, flexible, permits third party feature development, and can interact with other networks.

Abstract: A distributed features system is disclosed which permits a telecommunication network to accommodate the creation of open multimedia services. In accordance with an embodiment of the present invention, protocol extensions for a distributed feature system are disclosed which accommodate a broader range of media choices than conventional telephony. Protocols are disclosed for internal calls between modules in the distributed feature system that permit a module to open and close any number of media channels to be utilized in the communication usage. A protocol is also disclosed for internal calls between modules in the distributed feature system that is more appropriate for a packet-switched reference implementation.

Abstract: The present invention relates to a chemical milling solution and a chemical milling process for removing a desired depth of material from metal parts. The milling solution contains nitric acid, hydrofluoric acid, a wetting agent, such as a surfactant, dissolved titanium, and the balance water. The solution is maintained at a temperature in the range of from about 110° F. to about 130° F. The metal part to be milled is immersed in the milling solution for a time sufficient to remove a desired depth of material from at least one surface of the part.

Abstract: The present invention relates to a chemical milling solution and a chemical milling process for removing a desired depth of material from metal parts. The milling solution contains nitric acid, hydrofluoric acid, a wetting agent, such as a surfactant, dissolved titanium, and the balance water. The solution is maintained at a temperature in the range of from about 110° F. to about 130° F. The metal part to be milled is immersed in the milling solution for a time sufficient to remove a desired depth of material from at least one surface of the part.

Abstract: This invention provides proteins which selectively inhibit the proliferation of androgen-independent prostate cancer cells. This invention also provides a nucleic acid molecule encoding the instant proteins, including a nucleic acid molecule suitable for use in gene therapy for treating a subject afflicted with androgen-independent prostate cancer. This invention further provides a composition of matter which selectively kills androgen-independent prostate cancer cells, and comprises the instant proteins and a toxic moiety operably affixed thereto. Finally, the instant invention provides related pharmaceutical compositions and methods for treating androgen-independent prostate cancer.

Abstract: Production of monoglycerides is enhanced by means of enzymatic transesterification of triglycerides with aliphatic alcohols in a medium of supercritical CO.sub.2. Aliphatic primary and secondary alcohols of 1 to 8 carbon atoms may be used without support in supercritical CO.sub.2 at temperatures compatible for enzymatic transesterifion of tryglycerides. Utilization of these lower reaction temperatures has the benefit of diminishing the production of undesired side products and thus increasing the reaction efficiency with regard to production of the desired monoglycerides.

Abstract: A garment to be worn conveniently and comfortably over the upper body of a seagoing person to gain protection from rain, wind, and/or cold, which includes an interior deflated fluid tight enclosure, i.e. a bladder, to be very quickly inflated inside the garment in a time of emergency. The deflated fluid tight enclosure covers at least the interior upper back portion of this garment and also covers at least the interior of the right and left chest portions of this garment. An inflating subassembly is operatively secured between the deflated fluid tight enclosure and to either the right or left chest portion of this garment. This inflating subassembly has an alternatively usable mouth and lung inflatable valved air intake-discharge communicating with the deflated fluid tight enclosure, and an alternatively usable filled compressed fluid valved cylinder discharge also communicating with the deflated fluid tight enclosure and having a coilable pullable lanyard.

Abstract: A froth flotation machine (40) having a rotary air-supply shaft (42) vertically disposed in a vessel (41) includes an impeller (50) comprising a series of interconnected blades (52,53). Extending radially and fixedly depending from a flat impeller plate (52) is a pumping blade extending over one-half the distance from the plate outer periphery to the shaft. Blade (53) is an air-inducing vane of lesser radial length which aids in inducing air from shaft (42) to pumping blades (52). The vane has a height less than 50% of the height of the pumping blade. The pumping blade has an L/H ratio of from 0.8 to 1.4 where L is its radial length and H is its vertical height. Slurry is pumped by the blades (52) from bottom of the vessel through a central aperture in a surrounding fixed stator base (56) having stator bars (55) extending upwardly and forming parallel-sided passageways (63,64) for pumped fluid.