Abstract: The present disclosure relates generally to a polypeptide having mono-(2-hydroxyethyl) terephthalate hydrolase (MHETase) activity, more specifically to a polypeptide comprising an amino acid sequence that (i) has at least 70% sequence identity to SEQ ID NO:1 and (ii) differs from SEQ ID NO:1 by an amino acid substitution at one or more positions selected from the group consisting of positions that correspond to amino acid positions 156 to 396, 398 to 410 and 425 to 603 of SEQ ID NO:1.

Abstract: A delivery system may include a pallet wrapper system having a turntable, a camera directed toward an area above the turntable, and a stretch wrap dispenser adjacent the turntable. A computer receives images from the camera of multiple sides of a pallet loaded with packages on the turntable. The computer stitches images from different sides of the stack of packages that correspond to the same package. At least one machine learning model may be used to infer SKUs of each package. Optical character recognition may be performed in parallel on the images. The determination of the SKU of each package may be based upon the inferred SKUs and on the OCR.

Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured or humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: In examples, a method of controlling customer access to an assay system comprises (a) receiving a system identifier; (b) identifying said system identifier; and (c) utilizing information obtained from the system identifier to perform one or more operations selected from: (i) enabling full access to said system and/or a consumable used in said system; (ii) enabling partial access to said system and/or a consumable used in said system; or (iii) denying access to said system and/or a consumable used in said system.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.

Abstract: A system for applying a first coating composition and a second coating composition is provided herein. The system includes an atomizing applicator and a high transfer efficiency applicator defining a nozzle orifice. The system further includes a substrate assembly comprising a metal-containing substrate and a plastic-containing substrate. The metal-containing substrate is coupled to the plastic-containing substrate. The atomizing applicator is configured to apply the first coating composition to the metal-containing substrate. The high transfer efficiency applicator is configured to expel the second coating composition through the second nozzle orifice to the plastic-containing substrate.

Abstract: A fluid heating element includes first and second conduits. The first conduit has a first inlet and a first outlet. The first inlet is configured to receive a first portion of the fluid, and the first outlet is configured to discharge the first portion of the fluid. The second conduit has a second inlet and a second outlet. The second inlet is configured to receive a second portion of the fluid, and the second outlet is configured to discharge the second portion of the fluid. The fluid heating element further includes an electrothermal coating associated with the first and second conduits and an electrical lead configured to apply an electric current across the electrothermal coating. The electrothermal coating converts the electric current to heat that is transferred to through the first and second conduits to the fluid.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: A system and method of irrigation control calculates a predicted soil moisture value based that is compared to low moisture threshold. If the predicted soil moisture value is a value below the low moisture threshold value, the next irrigation cycle or scheduled irrigation operation is allowed to proceed or otherwise activated. The predicted soil moisture value may be calculated by adjusting a current soil moisture value by a historical adjustment factor based on negative net changes in soil moisture values.

Abstract: Systems and methods are provided for ozonolysis of polycyclic aromatic hydrocarbons (PAHs) in a liquid CO2 reaction environment. It has been unexpectedly discovered that oxygen-containing functional groups can be added to PAH substrates while substantially avoiding combustion reactions and while reducing or minimizing formation of energetic intermediates. Because the formation of energetic intermediates is minimal, the ozonolysis can be performed at temperatures near ambient (e.g., between ?10° C. and 50° C.) while still achieving a satisfactory safety profile. In various aspects, ozonolysis can occur while forming a reduced or minimized amount of water, such as forming substantially no water in the reaction environment.

Abstract: Systems and methods are provided for establishing a secure communication link between a first client and a second client. One exemplary computer-implemented method for establishing a secure communication link between a first diem and a second client includes accessing, from a storage, identification information of a user of the first client. The method further includes receiving a Domain Name Service (DNS) request from the first client requesting a secure network address corresponding to a secure domain name associated with the second client. The method further includes authenticating the user based on the user identification information. The method also includes transmitting the secure computer network address in response to the DNS request based on a determination that the user has been authenticated. A secure communication link between the first diem and the second client is established based on the secure computer network address.

Abstract: A screen attachment assembly is provided and includes a cover extending between a first cover end and a second cover end, a base extending between a first base end and a second base end, and a spline. The cover includes a lip extending from a cover body at the second cover end and an arm extending from the cover body. The base includes a first leg and a second leg extending from a base body in the same direction. The spline is disposed between the first and second legs. The first cover end of the cover is pivotally connected to the first base end such that the cover and base are integrated as a single piece. The cover is movable between an open position and a closed position such that the lip is positioned adjacent to the second leg and the arm abuts the first leg in the closed position.

Abstract: The invention relates to new tunicamycin structures comprising N-acyl groups metabolically integrated into the terminus of the TUN via the Streptomyces branched chain fatty acid pathways and variants thereof, and methods of preparing such new tunicamycin structures. The invention further relates to antibacterial compositions comprising such new tunicamycin structures, and methods for using such antibacterial compositions for killing Gram-positive bacteria.

Abstract: The present disclosure provides a new type of generalized artificial neural network where neurons and synapses maintain multiple states. While classical gradient-based backpropagation in artificial neural networks can be seen as a special case of a two-state network where one state is used for activations and another for gradients with update rules derived from the chain rule, example implementations of the generalized framework proposed herein may additionally: have neither explicit notion of nor ever receive gradients; contain more than two states; and/or implement or apply learned (e.g., meta-learned) update rules that control updates to the state(s) of the neuron during forward and/or backward propagation of information.

Abstract: Methods and systems are provided for assisting operation of a vehicle to satisfy a downpath energy constraint when a current energy state has deviated from a reference energy state according to a planned route of travel. One method involves identifying an intermediate energy constraint at an intermediate point en route to the downpath waypoint, determining a first segment for satisfying the intermediate energy constraint at the intermediate point from the current energy state using a first configuration, determining a second segment from the intermediate point that satisfies the requested energy constraint at the downpath waypoint using a different configuration, and providing graphical indicia of the recommended path including the first and second segments. The graphical indicia includes a first graphical indication of the first configuration associated with the first segment and a second graphical indication of the second configuration associated with the second segment.

Abstract: The present invention relates to a disposable safety glove system featuring a plurality of layers of inter-nested gloves that are worn simultaneously by a user. The improved disposable glove system of the present invention allows a user to peel away the outermost layer of gloves to reveal a new and sterile set of gloves. The glove system also features a relatively thick wristband to support the plurality of glove layers, a tab that can be used to easily peel off the outermost glove layer once the same has been used and a new pair of gloves is desired, and a numbering system that alerts the user to how many glove layers remain in the glove stack.

Abstract: Systems and methods capable of providing customized business processes, such as with regard to intermediate business transaction documents, within a standard business process flow system.

Abstract: Methods of forming a strained channel device utilizing dislocations disposed in source/drain structures are described. Those methods and structures may include forming a thin silicon germanium material in a source/drain opening of a device comprising silicon, wherein multiple dislocations are formed in the silicon germanium material. A source/drain material may be formed on the thin silicon germanium material, wherein the dislocations induce a tensile strain in a channel region of the device.