Abstract: The present disclosure relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.

Abstract: The present disclosure relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.

Abstract: The recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors of this invention encode heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.

Abstract: Particular aspects provide for use of the ?-herpesvirus Cytomegalovirus (CMV: e.g., RhCMV and HCMV) as a uniquely evolved “vector” for safely initiating and indefinitely maintaining high level cellular and humoral immune responses (against, e.g., HIV, SIV, TB, etc.). Particular aspects provide a method for treatment or prevention of, e.g., HIV, SIV or TB, comprising infection of a subject in need thereof with at least one recombinant CMV-based vector (e.g., HCMV or RhCMV) comprising an expressible HIV/SIV/TB antigen or a variant or fusion protein thereof. In particular embodiments of the method, infection is of an immunocompetent, HCMV or RhCMV seropositive subject. Additional aspects provide for RhCMV- and HCMV-based vaccine vectors, and versions thereof with suicide or safety means. Further aspects provide pharmaceutical compositions comprising the inventive CMV-based vaccine vectors.

Abstract: The present disclosure relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.

Abstract: The present invention relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.

Abstract: A natural draft, gravity feed pellet stove. The body of the stove is formed by a vertical section of large diameter pipe, with an air intake pipe extending from the back of the stove to below combustion grate. Pellet fuel is discharged onto the grate through a slot at the bottom of a hopper, and the grate is sloped so that the pellets roll away from the slot and over the grate as they are combusted. The combustion gasses flow into two exhaust pipes, each having a diameter similar to that of the intake pipe so as to establish a 2:1 exhaust/intake flow ratio. Cross-drilled reburner tubes are installed across the intake ends of the exhaust pipes to provide additional air for complete combustion. The bottom plates of the storage hopper are free from attachment along their lower edges, so that these expand and contract on a continuous basis with changes in the temperature of the stove; this causes cyclical distortion of the plates which shifts the fuel downwardly towards the discharge opening.

Abstract: A natural draft, gravity feed pellet stove. The body of the stove is formed by a vertical section of large diameter pipe, with an air intake pipe extending from the back of the stove to below a combustion grate. Pellet fuel is discharged onto the grate through a slot at the bottom of a hopper, and the grate is sloped so that the pellets roll away from the slot and over the grate as they are combusted. The combustion gasses flow into two exhaust pipes, each having a diameter similar to that of the intake pipe so as to establish a 2:1 exhaust/intake flow ratio. Cross-drilled reburner tubes are installed across the intake ends of the exhaust pipes to provide additional air for complete combustion. The bottom plates of the storage hopper are free from attachment along their lower edges, so that these expand and contract on a continuous basis with changes in the temperature of the stove; this causes cyclical distortion of the plates which shifts the fuel downwardly towards the discharge opening.