Abstract: An improved system and method to acquire physiological information about a state of a subject, such as SPECT and PET information. The system generates a predetermine sequence of pulse signals and combines that sequence with a first physiological signal to generate a time-base signal. The time-base signal is than combined with a second physiological signal. The combined signals are analyzed to determine accurate temporal synchronization of the first and second physiological signals. The system can be generalized to handle more than two physiological signals. Examples of physiological signals can be for example EKG signals, tomography signals, gross-body motion signals, respiratory motion signals, voluntary motion signals, involuntary motion signals and other signals. The analyzed data can be displayed and/or recorded, and provides physiological information about a state of the subject.

Abstract: An image reconstruction method comprises reconstructing an image using an iterative reconstruction method and computing a projection used in the reconstructing by summing ray increments between neighboring planes (P0, P1, P2, . . . ) parallel with a detector face (42) with stationary incremental blurring associated with each ray increment computed based on a distance between the neighboring parallel planes. A non-stationary blurring kernel may also be convolved at a plane closest to the detector face to generate a projection incorporating shift-variant blurring.

Abstract: An image reconstruction method comprises reconstructing an image using an iterative reconstruction method and computing a projection used in the reconstructing by summing ray increments between neighboring planes (P0, P1, P2, . . . ) parallel with a detector face (42) with stationary incremental blurring associated with each ray increment computed based on a distance between the neighboring parallel planes. A non-stationary blurring kernel may also be convolved at a plane closest to the detector face to generate a projection incorporating shift-variant blurring.

Abstract: The invention relates to methods and systems for compensating for respiratory motion of individuals during nuclear imaging. In some embodiments, the methods include obtaining data representing a reference respiratory state for the individual and obtaining data that represents a plurality of respiratory states that correspond to at least a portion of a cycle of respiration of the individual; comparing each of the plurality of respiratory states to a subset of the reference state data to obtain a motion estimate of each of the plurality of respiratory states; compensating for respiratory motion in each of the plurality of respiratory states based on the motion estimates to obtain motion-compensated respiratory state data; and constructing an image using the motion-compensated respiratory state data.

Abstract: The invention provides a system for modeling neurodegenerative and other diseases through somatic gene transfer. In addition, methods of multiple gene transfer, disease analysis and drug testing are provided for.

Abstract: A method of potentiating immunotoxin action in an immunotoxin/target-cell stem in which Brefeldin A is utilized as an immunopotentiator. The Brefeldin A enhances the immunotoxin pathway while blocking or inhibiting the nonspecific pathway, thus being particularly useful in conjunction with immunotoxins made from holotoxins. The Brefeldin A is effective in small, nontoxic concentrations and therefore may be utilized with either in vivo or in vitro systems.

Abstract: A scan conversion circuit for a thermal imager device in which a field is scanned by a parallel-series array of infra-red detectors swept broadside over the field to produce a band of parallel I.R. signals. The signals from the array of detectors are sampled at high speed in a pattern which traces each parallel line of detectors in turn. A C.R.T. is scanned in a similar pattern, the pattern being repeated at high speed with successive lateral displacements corresponding to the rate at which the I.R. array sweeps the field.