Patents by Inventor Michael A. Kron

Michael A. Kron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anthraquinones and process for the preparation and method of use thereof
    Patent number: 7658937
    Abstract: A process for the preparation of hydroxyl substituted anthraquinones is described. The process couples a phthalic anhydride (substituted or unsubstituted) to benzene ring moiety substituted with at least two hydroxyl groups. Remaining hydroxy groups were converted to methoxy groups in some anthraquinones. The compounds are particularly useful for the treatment of parasitic diseases. Also, a method of treating or preventing malaria, filariasis schistosomiasis and other parasitic diseases using anthraquinones.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: February 9, 2010
    Assignee: Board of Trustees of Michigan State University
    Inventors: Muraleedharan G. Nair, Mugunthu R. Dhananjeyan, Michael A. Kron, Youli P. Milev
  • Human asparaginyl-tRNA synthetase DNA
    Patent number: 6245539
    Abstract: The CDNA sequence of human cytosolic asparaginyl-tRNA synthesis AsnRS, the bacterial expression of the recombinant enzyme and its activity assays with different sources of tRNA is described. The reactivity with a human autoimmune serum is described. The implication of the human cytoplasmic AsnRS in an autoimmune disorder is a property of this enzyme.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: June 12, 2001
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Michael A. Kron, Michael M. Hartlein, Michito Hirikata
  • Assay for detection of filariasis using recombinant asparaginyl-tRNA synthetase from the human filrial parasite, Brugia malayi
    Patent number: 5846771
    Abstract: Recombinant asparaginyl tRNA synthetase from human filarial parasite Brugia malayi. The enzyme is used in an assay for inhibitors of the synthetase and can be used as an antigen for producing antibody inhibitors of the disease, either monoclonal or polyclonal. The antibodies can be used to detect the synthetase and related enzymes. In particular, the synthetase can be used to produce an antibody to be used for detecting filarial nematodes. The synthetase can be used to produce adenylated nucleosides.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: December 8, 1998
    Assignees: Board of Trustees operating Michigan State University, European Molecular Biology Laboratory
    Inventors: Michael A. Kron, Reuben Leberman
  • Recombinant asparaginyl-tRNA synthetase from the human filarial parasite, Brugia malayi
    Patent number: 5721116
    Abstract: Recombinant asparaginyl tRNA synthetase from human filarial parasite Brugia malayi. The enzyme is used in an assay for inhibitors of the synthetase and can be used as an antigen for producing antibody inhibitors of the disease, either monoclonal or polyclonal. The antibodies can be used to detect the synthetase and related enzymes. In particular, the synthetase can be used to produce an antibody to be used for detecting filarial nematodes. The synthetase can be used to produce adenylated nucleosides.
    Type: Grant
    Filed: April 9, 1996
    Date of Patent: February 24, 1998
    Assignees: Board of Trustees operating Michigan State University, European Molecular Biology Laboratory
    Inventors: Michael A. Kron, Reuben Leberman
  • Method of using recombinant asparaginyl-tRNA synthetase to detect human filarial parasite, Brugia malayi
    Patent number: 5695962
    Abstract: Recombinant asparaginyl tRNA synthetase from human filarial parasite Brugia malayi. The enzyme is used in an assay for inhibitors of the synthetase and can be used as an antigen for producing antibody inhibitors of the disease, either monoclonal or polyclonal. The antibodies can be used to detect the synthetase and related enzymes. In particular, the synthetase can be used to produce an antibody to be used for detecting filarial nematodes. The synthetase can be used to produce adenylated nucleosides.
    Type: Grant
    Filed: April 9, 1996
    Date of Patent: December 9, 1997
    Assignees: Board of Trustees operating Michigan State University, European Molecular Biology Laboratory
    Inventors: Michael A. Kron, Reuben Leberman
  • Recombinant asparaginyl-tRNA synthetase from the human filarial parasite, brugia malayi
    Patent number: 5561054
    Abstract: Recombinant asparaginyl tRNA synthetase from human filarial parasite Brugia malayi. The enzyme is used in an assay for inhibitors of the synthetase and can be used as an antigen for producing antibody inhibitors of the disease, either monoclonal or polyclonal. The antibodies can be used to detect the synthetase and related enzymes. In particular, the synthetase can be used to produce an antibody to be used for detecting filarial nematodes. The synthetase can be used to produce adenylated nucleosides.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: October 1, 1996
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Michael A. Kron, Reuben Leberman