Patents by Inventor Michael A. Kuzyk

Michael A. Kuzyk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8728823
    Abstract: A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: May 20, 2014
    Assignee: British Columbia Cancer Agency Branch
    Inventors: Stephen Lam, John Yee, Michael Kuzyk, Don Sin, Marianne Dorthy Sadar, Carl Martin Tammemagi
  • Patent number: 7851197
    Abstract: A protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
    Type: Grant
    Filed: July 8, 2009
    Date of Patent: December 14, 2010
    Assignee: Universitat Bern
    Inventors: Joachim Frey, Peter Kuhnert, Julian C. Thornton, Tracy A. Thornton, legal representative, Michael A. Kuzyk, Jan Burian, Martin Braun
  • Patent number: 7815896
    Abstract: Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: October 19, 2010
    Assignee: Universitat Bern
    Inventors: Joachim Frey, Katja Stuber, Julian C. Thornton, Michael A. Kuzyk, Jan Burian
  • Publication number: 20100248290
    Abstract: A method is described for detecting lung cancer comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject at risk for developing lung cancer. Further, a method is described for predicting risk of developing lung cancer in a subject comprising detecting an elevated level of a CTAP III-related biomarker in a biological sample from a subject. Additionally, a method of monitoring the success of lung cancer treatment with curative intent is described comprising detecting levels of a CTAP III-related biomarker in a biological sample from a subject undergoing treatment for lung cancer for comparison with the a previous level obtained from the subject. Multivariate analysis may be incorporated into these methods, evaluating such clinical, or demographic risk factors as age, sex, smoking history, smoking status, smoking family history, education level, COPD, socio-economic status, body mass index and lung function. Kits for conducting such methods are described.
    Type: Application
    Filed: November 24, 2008
    Publication date: September 30, 2010
    Applicant: BRITISH COLUMBIA CANCER AGENCY BRANCH
    Inventors: Stephen Lam, John Yee, Michael Kuzyk, Don Sin, Marianne Dorthy Sadar, Carl Martin Tammemagi
  • Publication number: 20100008895
    Abstract: A protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
    Type: Application
    Filed: July 8, 2009
    Publication date: January 14, 2010
    Applicant: UNIVERSITAT BERN
    Inventors: JOACHIM FREY, PETER KUHNERT, JULIAN C. THORNTON, TRACY A. THORNTON, MICHAEL A. KUZYK, JAN BURIAN, MARTIN BRAUN
  • Publication number: 20090226462
    Abstract: Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
    Type: Application
    Filed: March 4, 2009
    Publication date: September 10, 2009
    Inventors: Joachim Frey, Katja Stuber, Julian C. Thornton, Michael A. Kuzyk, Jan Burian
  • Patent number: 7579011
    Abstract: A novel protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventative, and therapeutic techniques, including the preparation of traditional, recombinant, and improved bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: August 25, 2009
    Assignee: Universitat Bern
    Inventors: Joachim Frey, Peter Kuhnert, Julian C. Thornton, Tracy A. Thornton, legal representative, Michael A. Kuzyk, Jan Burian, Martin Braun
  • Patent number: 7538208
    Abstract: Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: May 26, 2009
    Assignee: Universitat Bern
    Inventors: Joachim Frey, Katja Stuber, Julian C. Thornton, Michael A. Kuzyk, Jan Burian
  • Publication number: 20090074817
    Abstract: Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
    Type: Application
    Filed: September 29, 2006
    Publication date: March 19, 2009
    Inventors: Joachim Frey, Katja Stuber, Julian C. Thornton, Michael A. Kuzyk, Jan Burian
  • Patent number: 7351550
    Abstract: A protein toxin named Aeromonas salmonicida exoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: April 1, 2008
    Assignee: Universitat Bern
    Inventors: Joachim Frey, Peter Kuhnert, Tracy A. Thornton, legal representative, Michael A. Kuzyk, Jan Burian, Martin Braun, Julian C. Thornton
  • Publication number: 20070269462
    Abstract: A novel protein toxin named Aeromonas salmonicida exoenzyme T (AexT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a novel Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventative, and therapeutic techniques, including the preparation of traditional, recombinant, and improved bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
    Type: Application
    Filed: December 14, 2006
    Publication date: November 22, 2007
    Inventors: Joachim Frey, Peter Kuhnert, Julian Thornton, Tracy Thornton, Michael Kuzyk, Jan Burian, Martin Braun
  • Patent number: 7232569
    Abstract: Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: June 19, 2007
    Assignee: Universität Bern
    Inventors: Joachim Frey, Katja Stuber, Julian C. Thornton, Michael A. Kuzyk, Jan Burian
  • Publication number: 20050158344
    Abstract: A protein toxin named Aeromonas salmonicida exoenzyme T (AcxT), which belongs to the family of ADP-ribosylating toxins, is disclosed as is a Calcium (or other cation concentration) dependent promoter of A. salmonicida. Also disclosed are diagnostic, preventive, and therapeutic techniques, including the preparation of bacterin vaccines based on AexT for inducing immunity against A. salmonicida infections.
    Type: Application
    Filed: November 15, 2001
    Publication date: July 21, 2005
    Inventors: Joachim Frey, Peter Kuhnert, Julian Thornton, Tracy Thornton, Michael Kuzyk, Jan Burian, Martin Braun
  • Publication number: 20050058662
    Abstract: Disclosed is a newly identified and characterized type III secretion system in Aeromonas salmonicida. The invention also encompasses the use of components of the novel secretion system in immunoprotection against A. salmonicida infection, as well as other diagnostic and therapeutic uses thereof.
    Type: Application
    Filed: March 26, 2004
    Publication date: March 17, 2005
    Inventors: Joachim Frey, Katja Stuber, Julian Thornton, Michael Kuzyk, Jan Burian
  • Publication number: 20050002946
    Abstract: The use of the 17 kDa outer surface lipoprotein (OspA) of Piscirickettsia salmonis, or its homologues, as the basis of, or part thereof, a recombinant vaccine for salmonid rickettsial septicaemia and other rickettsial diseases is disclosed. Surface antigens of the bacterial pathogen P. salmonis are characterized and an immunoreactive antigen, namely the 17 kDa outer surface lipoprotein OspA of P. salmonis, as well as the nucleic acid segment that encodes the OspA immunoreactive antigen, is identified and characterized. Diagnostic techniques including the use of hybridization probes and primers as well as the production of specific antigens and antibodies that may be used in immunization techniques for inducing immunity against P. salmonis and other rickettsial diseases are disclosed, as are the development of recombinant vaccines for SRS and other rickettsial diseases based on the 17 kDa lipoprotein OspA.
    Type: Application
    Filed: February 18, 2004
    Publication date: January 6, 2005
    Inventors: Michael Kuzyk, Jan Burian, William Kay, Julian Thornton
  • Publication number: 20040086524
    Abstract: The use of the 17 kDa outer surface lipoprotein (OspA) of Piscirickettsia salmonis, or its homologues, as the basis of, or part thereof, a recombinant vaccine for salmonid rickettsial septicaemia and other rickettsial diseases is disclosed. Surface antigens of the bacterial pathogen P. salmonis are characterized and an immunoreactive antigen, namely the 17 kDa outer surface lipoprotein OspA of P. salmonis, as well as the nucleic acid segment that encodes the OspA immunoreactive antigen, is identified and characterized. Diagnostic techniques including the use of hybridization probes and primers as well as the production of specific antigens and antibodies that may be used in immunization techniques for inducing immunity against P. salmonis and other rickettsial diseases are disclosed, as are the development of recombinant vaccines for SRS and other rickettsial diseases based on the 17 kDa lipoprotein OspA.
    Type: Application
    Filed: September 30, 2002
    Publication date: May 6, 2004
    Inventors: Michael A. Kuzyk, Jan Burian, William W. Kay, Julian C. Thornton
  • Publication number: 20030165526
    Abstract: The use of the 17 kDa outer surface lipoprotein (OspA) of Piscirickettsia salmonis, or its homologues, as the basis of, or part thereof, a recombinant vaccine for salmonid rickettsial septicaemia and other rickettsial diseases is disclosed. Surface antigens of the bacterial pathogen P. salmonis are characterized and an immunoreactive antigen, namely the 17 kDa outer surface lipoprotein OspA of P. salmonis, as well as the nucleic acid segment that encodes the OspA immunoreactive antigen, is identified and characterized. Diagnostic techniques including the use of hybridization probes and primers as well as the production of specific antigens and antibodies that may be used in immunization techniques for inducing immunity against P. salmonis and other rickettsial diseases are disclosed, as are the development of recombinant vaccines for SRS and other rickettsial diseases based on the 17 kDa lipoprotein OspA.
    Type: Application
    Filed: September 30, 2002
    Publication date: September 4, 2003
    Inventors: Michael A. Kuzyk, Jan Burian, William W. Kay, Julian C. Thornton