Abstract: Methods and systems for analysis of image data generated from various reference points. Particularly, the methods and systems provided are useful for real time analysis of image and sequence data generated during DNA sequencing methodologies.

Abstract: The present disclosure is directed toward photonic elements comprising rib-waveguide-based ring resonators having high coupling efficiency between their bus and ring waveguides within the coupling region of the ring resonator, as well as operability over a wide spectral range. Embodiments disclosed herein employ a small-diameter ring waveguide and a bus waveguide that collectively define an asymmetrical coupler having a coupling region at which the optical confinement of the bus waveguide is stronger on side of the bus waveguide distal to the ring waveguide than on the side of the bus waveguide that is proximal to the ring waveguide. In some embodiments, in the coupling region, the bus waveguide has ridge and an inner bus-slab portion that is shared with the ring waveguide, while the outer bus-slab portion is at least partially removed to give rise to stronger optical confinement at the outer edge of the ridge of the bus waveguide.

Abstract: Embodiments described herein relate generally to a current interrupt device (CID) including a frangible bulb that is configured to be thermally triggered. In some embodiments, the CID includes a breaking contact electrically coupled to a fixed contact and held in electrical contact by the frangible bulb. In some embodiments, the frangible bulb is configured to break at a temperature threshold. In some embodiments, the breaking contact is configured to bend, rotate and/or otherwise deform about a hinge point in order to become electrically disconnected from the fixed contact when the frangible bulb breaks. In some embodiments, opening the electrical circuit between the breaking contact and the fixed contact may prevent overcharging, overvoltage conditions, overcurrent conditions, thermal runaway, and/or other catastrophic failure events.

Abstract: The method of this invention provides a simple and inexpensive method for manufacturing self-sealing pneumatic rubber tires of the tubeless type having a higher degree of uniformity than can be made utilizing conventional manufacturing procedures that are currently being practiced. In the practice of this invention a low viscosity sealant formulation, which would ordinarily be difficult to handle and build into an uncured tire, is encapsulated in a stiff rubber formulation. This makes it relatively easy to build the sealant layer into the tire since the low viscosity sealant formulation is contained with the more rigid solid material. The low viscosity sealant material requires little and preferably no depolymerization to act effectively as a sealant. Accordingly, it does not need to be depolymerized with a peroxide which causes off-gassing and the resultant tire uniformity and balance issues normally associated with polymer break down.

Abstract: The present application provides a beverage dispenser for dispensing a beverage in a contactless fashion. The beverage dispenser may include a number of adjacent dispensing valves with each of the dispensing valves including a nozzle and a contactless dispensing valve system. The contactless dispensing valve system includes one or more proximity sensors positioned under the nozzle of each of the adjacent dispensing valves.

Abstract: Embodiments described herein include electrochemical cell modules. In some aspects, an electrochemical cell module includes a first electrochemical cell and a second electrochemical cell. The first electrochemical cell includes an anode material disposed on an anode current collector, a cathode material disposed on a cathode current collector, a separator disposed between the anode material and the cathode material, and a pouch material disposed on the anode current collector and the cathode current collector. The separator extends beyond the anode material and the cathode material and the pouch material extends beyond the separator. The portion of the separator that extends beyond the outer edge of the anode material and the cathode material and the portion of the pouch material that extends beyond the outer edge of the separator are folded at an angle of about 80 degrees to about 110 degrees with respect to the anode material and the cathode material.

Abstract: Hybrid on-policy/off-policy techniques are provided for improving the estimation of quality (reward) of a control policy for decision making by combining the on-policy and off-policy data from multiple estimators into a single metric. In one aspect, a method for estimating a reward of a policy for decision making in a computer system includes: computing multiple reward estimates of the policy using estimators, wherein at least a subset of the estimators compute reward estimates with prediction intervals; and combining the multiple reward estimates using a combiner to produce a new reward estimate. Thus, some of the estimators might compute the reward estimates without prediction intervals. A method for estimating a reward of a policy when another one or more of the estimators compute reward estimates without prediction intervals is also provided.

Abstract: A quad-shield coaxial cable includes an insulator portion configured to encircle an inner conductor portion, an inner conductive foil portion configured to encircle the insulator portion, an inner braided shield portion configured to encircle the inner conductive foil layer portion, an outer braided shield portion configured to encircle the inner braided shield portion, an outer conductive foil portion configured to encircle the outer braided shield portion, and a jacket portion configured to encircle the outer conductive foil portion.

Abstract: The pneumatic tires of this invention are of the tubeless type, are capable of self-sealing punctures made therein, and generate a low level of noise during use on a vehicle. These tires have a sealant/noise reduction layer which is disposed inwardly from the supporting carcass and which is typically the innermost layer of the tire. The sealant/noise reduction layer is comprised of a dispersed phase and a continuous phase, wherein the dispersed phase is comprised of a sealant material, and wherein the continuous phase is comprised of a foamed polymeric material.

Abstract: Embodiments described herein relate to current interrupt devices (CIDs) for electrochemical cells that use a thermal trigger (e.g., shape memory and/or bi-metallic materials) to open an electrical circuit just prior to a thermal runaway or during short-circuit event to prevent catastrophic failure of the electrochemical cell. Embodiments include CIDs comprising a housing, a bus bar coupled to the housing, and a thermal trigger operably coupled to the bus bar. In some embodiments, the bus bar can include an engineered fracture site. In some embodiments, the thermal trigger is dimensioned and configured to deform at a predetermined temperature to break the bus bar at the engineered fracture site. In some embodiments, a portion of the bus bar travels about a hinge, opening the electrical circuit and preventing overcharging, thermal runaway, and/or other catastrophic failure events.

Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.

Abstract: An air spring includes a first body; a first piston cooperating with the first body to define a pressurized first chamber including a gas, the first piston configured to slideably move relative to the first body; a pressurized second chamber; a flow passage between the first chamber and the second chamber; and a seal to selectively permit or restrict flow between the first chamber and the second chamber depending on a position of the first piston with respect to the first body.

Abstract: Methods and systems for analysis of image data generated from various reference points. Particularly, the methods and systems provided are useful for real time analysis of image and sequence data generated during DNA sequencing methodologies.

Abstract: A chamberless smoke detector includes a source laser, a grating coupler, a transmitting optical phase array, a receiving optical phase array, and a processing unit.

Abstract: It has been found that carboxylic acid functionalized high cis-1,4-polybutadiene rubber which is comprised of polybutadiene rubber chains having a cis-1,4-microstructure content of at least 90 percent has much better interaction with metal salts of ?,?-ethylenically unsaturated carboxylic acids, such as zinc diacrylate or zinc dimethacrylate. This results in such rubber compositions being stiff while still exhibiting a lower level of hysteresis. These characteristics are beneficial when used in manufacturing tire apex compositions, in manufacturing golf ball cores, and in a wide variety of other applications. Such rubber compositions can be used as substitutes for thermoplastic elastomers in many applications.

Abstract: Provided is a gas fill fixture for use in lyophilization, a related system and method. The gas fill fixture includes a chassis, fill indicator and a lid, such that the chassis and lid together form a cavity for receiving a flexible lyophilization container. The system includes a lyophilization container, a lyophilizer and a gas fill fixture incorporating a chassis, a fill indicator and a lid. The method includes process steps for using the system to lyophilize a fluid.

Abstract: A computing system for generating a dynamic path for a fellow, includes a processor and a memory storing instructions that when executed by the processor cause the computing system to receive the fellow's skill graph, receive a target skill, receive a calendar object and generate the dynamic path including a task and/or a session. A non-transitory computer readable medium includes program instructions that when executed, cause a computer to receive the fellow's skill graph, receive a target skill, receive a calendar object and generate the dynamic path including a task and/or a session. A method for generating a dynamic path for a fellow includes receiving the fellow's skill graph, receiving a target skill, receiving a calendar object and generating the dynamic path including a task and/or a session.

Abstract: The invention provides a novel class of orally and/or topically available, selective and potent JAK inhibitors as safe and effective therapeutics against various diseases and disorders. The invention also provides pharmaceutical composition of these compounds and methods of their preparation and use thereof.

Abstract: A helmet accessory mounting system includes a mounting device configured to couple to an outer surface of a side of a helmet. The mounting device includes a plurality of mounting locations configured to removeably couple to at least one accessory. A plurality of the plurality of mounting locations each includes an electrical node. A power supply is coupled to the mounting device. An electrical supply line electrically couples the power supply to each of the electrical nodes and the electrical supply line is contained at least partially within the mounting device.