Abstract: Disclosed herein are systems, methods, and computer program products for operating a lidar system (LS). The methods comprise: receiving result values (RVs) from photodetectors (the RVs based on operations performed by each photodetector to facilitate measurements associated with a light signal reflected off an object external to LS); combining different sets of RVs to generate super pixels; using super pixels to obtain spatiotemporal coherence metrics; selecting a subset of light pulses or a group of RVs based on the spatiotemporal coherence metrics; and detecting a distance between LS and object based on the selected subset of light pulses or the selected group of RVs. The methods enable variable resolution imaging systems in which the resolution of the pixel can be configured to automatically integrate a variable number of spatial and temporal measurements that belong to the same object to improve detection quality rather than using a fixed number of measurements.

Abstract: A product management computer system that can include one or more processors, and a computer-readable medium comprising instructions stored therein, which when executed by the processors, can cause the processors to: receive data representing a target product of interest to a user of the system, wherein the target product is described by a plurality of variable-value attributes associated; process the received data through a machine-learning-produced algorithm and generating data representing a first set of substitute product candidates for the target product and wherein each substitute product candidate has a corresponding match-score that represents a degree of determined similarity between that substitute product candidate and the target product; transform the generated data that represents the first set of substitute product candidates into data representing a refined set of substitute product candidates by processing the generated data utilizing a constraint-based algorithm; and output data representing

Abstract: A differential for a vehicle includes a final drive gear with a final drive gear spline, a differential carrier with a differential carrier spline, and an axially slidable clutch. The axially slidable clutch includes a first clutch spline drivingly engaged with a one of the final drive gear spline or the differential carrier spline and a second clutch spline for selectively drivingly engaging with the other one of the final drive gear spline or the differential carrier spline. In an example embodiment, the differential also includes a pair of side gears, each including an inner spline for drivingly engaging a respective axle shaft, a pair of radially offset spider gears, each drivingly engaged with both of the side gears, and a shaft extending through the pair of radially offset spider gears into the differential carrier.

Abstract: A multiplexer includes a charging circuit; a plurality of sampling switches receiving a plurality of input signals; and a plurality of boosting circuits connected between the sampling switches and the charging circuit and sharing the charging circuit. First and second charging switches of the charging circuit are controlled by a first clock signal. Each of the boosting circuits includes a first boosting switch connected to a first node of the charging circuit and a gate of one of the sampling switches, a second boosting switch connected between a second node of the charging circuit and the one sampling switch, and a level shifter configured to control the first boosting switch and the second boosting switch in response to a second clock signal and a selection signal.

Abstract: An ophthalmic device includes an optic including an optic axis and a closed-loop haptic structure coupled to the optic via a frame surrounding the optic, the closed-loop haptic structure including a closed loop extending from first and second attachment points to the frame. The closed loop includes a first hinge and a second hinge. The first hinge has a first section having a first component extending in a first angular direction, a second section having a second component extending in a second angular direction opposite to the first angular direction, and a first connecting section between the first section and the second section. The second hinge has a third section having a third component extending in the second angular direction, a fourth section having a fourth component extending in the first angular direction, the fourth section being connected to the second section to form the closed loop.

Abstract: Fibrous structures comprising spunbond filaments and solid additives and methods for making such fibrous structures are provided.

Abstract: The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, a pharmaceutical use thereof, and a method for preparing the same. According to the present invention, the novel compounds, optical isomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; internal secretion; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, and chromosomal aberration.

Abstract: Aspects described herein may relate to a transaction exchange platform using a streaming data platform (SDP) and microservices to process transactions according to review and approval workflows. The transaction exchange platform may receive transactions from origination sources, which may be added to the SDP as transaction objects. Microservices on the transaction exchange platform may interact with the transaction objects based on configured workflows associated with the transactions. Processing on the transaction exchange platform may facilitate clearing and settlement of transactions. Some aspects may provide for dynamic and flexible reconfiguration of workflows and/or microservices. Other aspects may provide for data snapshots and workflow tracking, allowing for monitoring, quality control, and auditability of transactions on the transaction exchange platform.

Abstract: An inspection apparatus includes a specimen stage configured to retain a specimen, at least three imaging devices arranged in a triangular array positioned above the specimen stage, each of the at least three imaging devices configured to capture an image of the specimen, one or more sets of lights positioned between the specimen stage and the at least three imaging devices, and a control system in communication with the at least three imaging devices.

Abstract: Aneurysms are treated by filling at least one double-walled filling structure with a curable medium within the aneurysm. The filling structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Scaffolds are placed into the tubular lumens in order to help maintain the shape, anchor the filling structures in place, and provide improved blood flow transition into and out of the tubular lumens.

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

Abstract: Described herein are systems and methods from delivering prosthetic devices, such as prosthetic heart valves, through the body and into the heart for implantation therein. The prosthetic devices delivered with the delivery systems disclosed herein are, for example, radially expandable from a radially compressed state mounted on the delivery system to a radially expanded state for implantation using an inflatable balloon of the delivery system. Exemplary delivery routes through the body and into the heart include transfemoral routes, transapical routes, and transaortic routes, among others.

Abstract: Devices for removing implanted objects from body vessels are provided. A device includes a sheath assembly having a cutting tip. The cutting tip includes a cutting surface that is adapted to cut tissue coupled to an implanted object as the cutting tip rotates. The sheath assembly further includes an outer shield carried outside of the cutting tip. The outer shield includes a distal opening, and the outer shield is translatable relative to the cutting tip from a first position to a second position and vice versa. In the first position the cutting surface of the cutting tip is disposed within the outer shield, and in the second position the cutting tip extends through the distal opening and the cutting surface is at least partially disposed outside of the outer shield.

Abstract: Various implementations disclosed herein include devices, systems, and methods that provide customized feedback content during a meditation experience. For example, an example process may include obtaining physiological data via one or more sensors, determining that an attentive state based on the physiological data, customizing feedback content based on a user attribute to change the attentive state during the meditation mode, and providing the customized feedback content during the meditation mode after a delay time based on the user attribute.

Abstract: The present disclosure is concerned with 6-aza-nucleoside prodrugs that are capable of inhibiting a viral infection and methods of treating viral infections such as, for example, human immunodeficiency virus (HIV), human papillomavirus (HPV), chicken pox, infectious mononucleosis, mumps, measles, rubella, shingles, ebola, viral gastroenteritis, viral hepatitis, viral meningitis, human metapneumovirus, human parainfluenza virus type 1, parainfluenza virus type 2, parainfluenza virus type 3, respiratory syncytial virus, viral pneumonia, yellow fever virus, tick-borne encephalitis virus, Chikungunya virus (CHIKV), Venezuelan equine encephalitis (VEEV), Eastern equine encephalitis (EEEV), Western equine encephalitis (WEEV), dengue (DENV), influenza, West Nile virus (WNV), zika (ZIKV), Middle East Respiratory Syndromes (MERS), Severe Acute Respiratory Syndrome (SARS), and coronavirus disease 2019 (COVID-19), using these compounds.

Abstract: According to various embodiments, a direct magnetic gradiometer having intrinsic subtraction of rotation signals from two oppositely polarized atomic ensembles within a single multi-pass cell is disclosed. The gradiometer includes three convex spherical mirrors aligned in a V-shape geometry. The three convex spherical mirrors include a front mirror and two back mirrors. The gradiometer further includes a probe laser beam. The laser beam is configured to be initially focused at a near-zero angle into a hole at a center of the front mirror such that the laser beam expands at the back mirrors and nearly overlaps with itself while undergoing multiple reflections between the front and back mirrors. The laser beam is further configured to be refocused to the front mirror at different spots in a number equal to half of total beam passes before exiting.

Abstract: A solar tracking mounting system is provided. The tracking system has an anchor comprising a pile and a riser bracket fastened to the top thereof, wherein the riser bracket is configured to provide adjustable mounting points, a chord assembly coupled to with the riser brackets, wherein the chord assembly is configured to pivotability tilt, a kicker connected to the anchor assembly, wherein the kicker is configured to connect the chord assembly to the pile, a vertical actuator connected to the kicker and the chord assembly, wherein the vertical actuator is a rack and pinion linear actuator configured to amplify a torque received from a motor and pivotably tilt to the chord assembly to a desired angle while tracking a direction of a light source, and a driveshaft connected to the motor and the vertical actuator. A jack screw may also be provided therein for actuation.

Abstract: A system is disclosed herein. The system includes a splitter board. The splitter board includes a microprocessor, a converter, and a bypass relay. The converter includes analog-to-digital circuitry and digital-to-analog circuitry. The bypass relay is configurable between a first state and a second state. In the first state, the bypass relay is configured to direct an input signal to the converter. The converter converts the input signal to a converted input signal and splits the converted input signal into a first portion and a second portion. The first portion is directed to the microprocessor. The second portion is directed to an output port of the splitter board for downstream processes. In the second state, the bypass relay is configured to cause the input signal to bypass the converter. The bypass relay directs the input signal to the output port of the splitter board for the downstream processes.

Abstract: A method and apparatus of limiting power of a boiling water nuclear reactor system includes a reactor pressure vessel, a reactor core disposed in the reactor pressure vessel, a core shroud surrounding the reactor core, a downcomer region disposed between an inner surface of the reactor pressure vessel and the core shroud, a steam line connected to an upper end of the reactor pressure vessel and a condenser system that receives steam from the reactor pressure vessel. A portion of the condenser system condensate is returned to the reactor pressure vessel of the boiling water reactor inside the core barrel above the core rather than into the downcomer. Returning the condensate in this way increases the effectiveness of an isolation condenser system or if the condensate is a portion of the feedwater from the main condenser it provides an effective means to regulate core flow and core power.

Abstract: A filling method and process for a flower cartridge for use with a portable electronic heating device for the smokeless delivery of active ingredients and volatile compounds released from heating natural consumables such as plant matter is disclosed. Through grinding, vibration, and tamping, a number of cartridges are filled with natural consumables. Compressive forces applied via tamping, coupled with a constriction or obstruction within the cartridge, form a porous plug to which air flows freely but the consumables remain in place. The filling process minimizes oxidation and preserves the shelf life of the flower cartridge.