Patents by Inventor Michael A. Lehr

Michael A. Lehr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240019318
    Abstract: An electronic device may include one or more ultrasonic temperature sensors. The ultrasonic temperature sensors may be formed in openings or cavities in a housing of the electronic device. The ultrasonic temperature sensors may include ultrasonic transmitters that transmit signals at different ultrasonic frequencies and ultrasonic receivers that receive the transmitted signals. Phase differences between the received ultrasonic signals may be used to determine the speed of sound of ambient air and therefore calculate the temperature of the ambient air. The ultrasonic transmitters and receivers may include piezoelectric micromachined ultrasound transducers (PMUTs). Each transmitter and receiver may be a dedicated transmitter or receiver, or may transmit and receive ultrasonic signals. Each receiver may include an array of PMUTs that receive ultrasonic signals of different frequencies. The PMUTS may be formed on complementary metal-oxide semiconductors (CMOS).
    Type: Application
    Filed: April 20, 2023
    Publication date: January 18, 2024
    Inventors: Krishna Prasad Vummidi Murali, Patrick R. Gill, Chaitanya Mudivarthi, Roberto M Ribeiro, Mohammad Waleed Shinwari, Flavius Pop, Michael A Lehr
  • Patent number: 11839658
    Abstract: The present invention relates to conjugates of aminoglycosides and terpenoids, in particular sesquiterpenoids. Furthermore, the present invention relates to nano-assemblies formed by the inventive conjugates and to a method for producing the conjugates and/or the nano-assemblies. The present invention also relates to the inventive conjugates and nano-assemblies for use in therapy, in particular for use in the treatment of infectious diseases. Particularly preferred embodiments of the present invention relate to farnesylated aminoglycosides and nano-assemblies thereof, in which farnesol and its derivatives do not only function as carrier for the aminoglycosides but do themselves have pharmaceutical activity upon cleavage of the conjugate, in particular quorum sensing inhibitory activity.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: December 12, 2023
    Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Duy-Khiet Ho, Brigitta Loretz, Claus-Michael Lehr
  • Patent number: 11798010
    Abstract: Improved systems and methods for database management using data normalization and defragmentation techniques are provided. At least one exchange processor in communication with an exchange computer system receives market data from the exchange computer system, processes the market information, and transmits the market data to a master processor. The master processor receives the market data, processes the data using at least one normalization process to generate normalized data including an intra-day file and an archival file, and stores the intra-day file and the archival file in the master database. The master processor transmits the intra-day file and the archival file to the at least one regional processor.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: October 24, 2023
    Assignee: MAYSTREET INC.
    Inventors: Niall Douglas, Robert Leahy, Michael Lehr
  • Publication number: 20230333394
    Abstract: A head-mounted device or other electronic device may emit an alternating-current magnetic field. A wireless controller may have alternating-current magnetometers for monitoring the alternating-current field. The wireless controller may also have an accelerometer for measuring the orientation of the controller relative to the Earth's gravity and a direct-current magnetometer for measuring the orientation of the controller relative to the Earth's magnetic field. The alternating-current magnetometers may be three-coil magnetometers located at different locations in a controller housing. Using data from the alternating-current magnetometers, the direct-current magnetometer, the accelerometer, and/or other sensors, the wireless controller can determine the position and orientation of the wireless controller. This information can be wirelessly transmitted to the head-mounted device to control the head-mounted device.
    Type: Application
    Filed: March 8, 2023
    Publication date: October 19, 2023
    Inventors: Yuhao Pan, Guangwu Duan, Jeffrey A. Griffis, John G. Elias, Krishna Prasad Vummidi Murali, Michael A. Lehr, Savas Gider, Stephen E. Dey
  • Publication number: 20230285590
    Abstract: Polymer-cargo-complexes including cross-linked copolymers and cargo molecules bound to the copolymers by electrostatic interactions. The non-medical use thereof for transfection and to a kit including such polymer-cargo-complexes. The polymer-cargo-complexes for use in therapy, in particular for use in gene therapy or peptide/protein drug delivery. A method of preparing the polymer-cargo-complexes. A kit for preparing a polymer-cargo-complex of the invention.
    Type: Application
    Filed: June 18, 2021
    Publication date: September 14, 2023
    Inventors: Sangeun LEE, Brigitta LORETZ, Claus-Michael LEHR, K.H. Anna HIRSCH
  • Patent number: 11332726
    Abstract: The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: May 17, 2022
    Assignees: EBERHARD KARLS UNIVERSITÄT TÜBINGEN MEDIZINISCHE FAKULTÄT, HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH FÜR DAS HELMHOLTZ-INSTITUT FÜR PHARMAZEUTISCHE FORSCHUNG SAARLAND (HIPS)
    Inventors: Michael Kormann, Lauren Mays Weddle, Claus-Michael Lehr, Brigitta Loretz, Emad Malaeksefat
  • Publication number: 20220044259
    Abstract: Improved systems and methods for database management using data normalization and defragmentation techniques are provided. At least one exchange processor in communication with an exchange computer system receives market data from the exchange computer system, processes the market information, and transmits the market data to a master processor. The master processor receives the market data, processes the data using at least one normalization process to generate normalized data including an intra-day file and an archival file, and stores the intra-day file and the archival file in the master database. The master processor transmits the intra-day file and the archival file to the at least one regional processor.
    Type: Application
    Filed: August 6, 2020
    Publication date: February 10, 2022
    Applicant: Maystreet, Inc.
    Inventors: Niall Douglas, Robert Leahy, Michael Lehr
  • Publication number: 20200360524
    Abstract: The present invention relates to conjugates of aminoglycosides and terpenoids, in particular sesquiterpenoids. Furthermore, the present invention relates to nano-assemblies formed by the inventive conjugates and to a method for producing the conjugates and/or the nano-assemblies. The present invention also relates to the inventive conjugates and nano-assemblies for use in therapy, in particular for use in the treatment of infectious diseases. Particularly preferred embodiments of the present invention relate to farnesylated aminoglycosides and nano-assemblies thereof, in which farnesol and its derivatives do not only function as carrier for the aminoglycosides but do themselves have pharmaceutical activity upon cleavage of the conjugate, in particular quorum sensing inhibitory activity.
    Type: Application
    Filed: June 8, 2018
    Publication date: November 19, 2020
    Applicant: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Duy-Khiet HO, Brigitta LORETZ, Claus-Michael LEHR
  • Publication number: 20190376051
    Abstract: The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.
    Type: Application
    Filed: April 30, 2019
    Publication date: December 12, 2019
    Applicants: Eberhard Karls Universität Tübingen Medizinische Fakultät, Helmholtz-Zentrum für Infektionsforschung GmbH für das Helmholtz-Institut für Pharmazeutische
    Inventors: Michael KORMANN, Lauren Mays WEDDLE, Claus-Michael LEHR, Brigitta LORETZ, Emad MALAEKSEFAT
  • Patent number: 10496209
    Abstract: An electronic device can include a force and touch sensing system. In one embodiment, an input force sensor device of an electronic device is disclosed.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: December 3, 2019
    Assignee: Apple Inc.
    Inventors: Krishna Prasad Vummidi Murali, Hari Vasudevan, Michael A. Lehr, Wesley S. Smith
  • Patent number: 10383950
    Abstract: The present invention relates to a carrier system, a carrier and a pharmaceutical composition comprising a pathogen entry protein or fragment thereof, which specifically binds to a molecule on the surface of a mammalian target cell of said pathogen and which is covalently linked to the surface of said carrier and at least one hydrophilic antipathogenic agent. It further relates to a method of manufacturing a carrier system and the carrier system or the pharmaceutical composition for the use as a medicament.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: August 20, 2019
    Assignee: HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH (DE/DE)
    Inventors: Claus-Michael Lehr, Hagar Ibrahim Labouta, Sarah Gordon, Arianna Castoldi, Sara Menina, Rebecca Geyer, Annika Kochut, Petra Dersch
  • Publication number: 20180284936
    Abstract: An electronic device can include a force and touch sensing system. In one embodiment, an input force sensor device of an electronic device is disclosed.
    Type: Application
    Filed: November 14, 2017
    Publication date: October 4, 2018
    Inventors: Krishna Prasad Vummidi Murali, Hari Vasudevan, Michael A. Lehr, Wesley S. Smith
  • Publication number: 20170232114
    Abstract: The present invention relates to a carrier system, a carrier and a pharmaceutical composition comprising a pathogen entry protein or fragment thereof, which specifically binds to a molecule on the surface of a mammalian target cell of said pathogen and which is covalently linked to the surface of said carrier and at least one hydrophilic antipathogenic agent. It further relates to a method of manufacturing a carrier system and the carrier system or the pharmaceutical composition for the use as a medicament.
    Type: Application
    Filed: August 14, 2015
    Publication date: August 17, 2017
    Applicant: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH
    Inventors: Claus-Michael LEHR, Hagar Ibrahim LABOUTA, Sarah GORDON, Arianna CASTOLDI, Sara MENINA, Rebecca GEYER, Annika KOCHUT, Petra DERSCH
  • Patent number: 9671300
    Abstract: An electronic device may include one or more low-noise pressure sensors for measuring air pressure. The electronic device may include wireless communications circuitry for communicating with external devices also having pressure sensors. Pressure data gathered by an external device may be used as reference pressure data for the electronic device. For example, if both devices are located in the same building, both pressure sensors will detect similar pressure fluctuations due to doors opening and closing and temperature-control systems turning on and off. By subtracting the reference pressure data from the pressure data gathered by the electronic device, calibrated pressure data may be obtained and may be used to reliably detect vertical displacement changes of the electronic device. In other scenarios, the pressure data may be compared with the reference pressure data to determine whether the two devices are in the same room.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: June 6, 2017
    Assignee: Apple Inc.
    Inventors: Stuart K. Neubarth, Michael A. Lehr, David MacNeil, Henry H. Yang
  • Publication number: 20160273986
    Abstract: An electronic device may include one or more low-noise pressure sensors for measuring air pressure. The electronic device may include wireless communications circuitry for communicating with external devices also having pressure sensors. Pressure data gathered by an external device may be used as reference pressure data for the electronic device. For example, if both devices are located in the same building, both pressure sensors will detect similar pressure fluctuations due to doors opening and closing and temperature-control systems turning on and off. By subtracting the reference pressure data from the pressure data gathered by the electronic device, calibrated pressure data may be obtained and may be used to reliably detect vertical displacement changes of the electronic device. In other scenarios, the pressure data may be compared with the reference pressure data to determine whether the two devices are in the same MOM.
    Type: Application
    Filed: March 16, 2015
    Publication date: September 22, 2016
    Inventors: Stuart K. Neubarth, Michael A. Lehr, David MacNeil, Henry H. Yang
  • Patent number: 9393218
    Abstract: The subject of this application is the use of film-forming polyurethanes that are used in hair care agents or mixtures of these polyurethanes with other polymers in pharmaceutical preparations for dermal or transdermal administration of active ingredients, as well as patches and pharmaceutical preparations that contain these hair care polyurethanes.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: July 19, 2016
    Assignee: EPINAMICS GMBH
    Inventors: Ines Zurdo Schroeder, Patrick Franke, Stefan Bracht, Claus-Michael Lehr, Ulrich Schäfer
  • Patent number: 9225392
    Abstract: A coil assembly is disclosed. The coil assembly includes a coil that is provided on a substrate. The coil includes a trace element that is wound on the substrate. The trace element includes an interior gap that extends or is present along at least a portion of the trace element. The interior gap is dimensioned to reduce a presence of eddy currents that would otherwise be generated when the coil is active to inductively transmit or receive signals.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: December 29, 2015
    Assignee: QUALCOMM Incorporated
    Inventors: Michael Lehr, Manjirnath Chatterjee, Dyke Shaffer, Eric Liu
  • Patent number: 8712324
    Abstract: At least two devices are provided that can each form part of a system to inductively exchange power and data. One device is capable of inductively transmitting a power signal to a second device, and to receive feedback from the second device in order to regulate the power signal.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: April 29, 2014
    Assignee: QUALCOMM Incorporated
    Inventors: Mark Corbridge, Manjirnath Chatterjee, Michael Lehr, Allan Hessenflow, Stuart Neubarth, Jacob Rasco
  • Publication number: 20130308256
    Abstract: A coil assembly is disclosed. The coil assembly includes a coil that is provided on a substrate. The coil includes a trace element that is wound on the substrate. The trace element includes an interior gap that extends or is present along at least a portion of the trace element. The interior gap is dimensioned to reduce a presence of eddy currents that would otherwise be generated when the coil is active to inductively transmit or receive signals.
    Type: Application
    Filed: March 9, 2011
    Publication date: November 21, 2013
    Applicant: Hewlett-Packard Development Company, L.P.
    Inventors: Michael Lehr, Manjirnath Chatterjee, Dyke Shaffer, Eric Liu
  • Patent number: 8437695
    Abstract: An inductive signal interface comprises a coil assembly including one or more inductive coils, a bridge circuit including a plurality of switches, and control circuitry. The control circuitry is configured to individually operate the plurality of switches to enable the inductive signal interface to dynamically switch between a power-transmit mode and a power receive mode.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: May 7, 2013
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Manjirnath Chatterjee, Michael Lehr, Dyke Shaffer