Patents by Inventor Michael A. Lehr
Michael A. Lehr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240019318Abstract: An electronic device may include one or more ultrasonic temperature sensors. The ultrasonic temperature sensors may be formed in openings or cavities in a housing of the electronic device. The ultrasonic temperature sensors may include ultrasonic transmitters that transmit signals at different ultrasonic frequencies and ultrasonic receivers that receive the transmitted signals. Phase differences between the received ultrasonic signals may be used to determine the speed of sound of ambient air and therefore calculate the temperature of the ambient air. The ultrasonic transmitters and receivers may include piezoelectric micromachined ultrasound transducers (PMUTs). Each transmitter and receiver may be a dedicated transmitter or receiver, or may transmit and receive ultrasonic signals. Each receiver may include an array of PMUTs that receive ultrasonic signals of different frequencies. The PMUTS may be formed on complementary metal-oxide semiconductors (CMOS).Type: ApplicationFiled: April 20, 2023Publication date: January 18, 2024Inventors: Krishna Prasad Vummidi Murali, Patrick R. Gill, Chaitanya Mudivarthi, Roberto M Ribeiro, Mohammad Waleed Shinwari, Flavius Pop, Michael A Lehr
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Patent number: 11839658Abstract: The present invention relates to conjugates of aminoglycosides and terpenoids, in particular sesquiterpenoids. Furthermore, the present invention relates to nano-assemblies formed by the inventive conjugates and to a method for producing the conjugates and/or the nano-assemblies. The present invention also relates to the inventive conjugates and nano-assemblies for use in therapy, in particular for use in the treatment of infectious diseases. Particularly preferred embodiments of the present invention relate to farnesylated aminoglycosides and nano-assemblies thereof, in which farnesol and its derivatives do not only function as carrier for the aminoglycosides but do themselves have pharmaceutical activity upon cleavage of the conjugate, in particular quorum sensing inhibitory activity.Type: GrantFiled: June 8, 2018Date of Patent: December 12, 2023Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBHInventors: Duy-Khiet Ho, Brigitta Loretz, Claus-Michael Lehr
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Patent number: 11798010Abstract: Improved systems and methods for database management using data normalization and defragmentation techniques are provided. At least one exchange processor in communication with an exchange computer system receives market data from the exchange computer system, processes the market information, and transmits the market data to a master processor. The master processor receives the market data, processes the data using at least one normalization process to generate normalized data including an intra-day file and an archival file, and stores the intra-day file and the archival file in the master database. The master processor transmits the intra-day file and the archival file to the at least one regional processor.Type: GrantFiled: August 6, 2020Date of Patent: October 24, 2023Assignee: MAYSTREET INC.Inventors: Niall Douglas, Robert Leahy, Michael Lehr
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Publication number: 20230333394Abstract: A head-mounted device or other electronic device may emit an alternating-current magnetic field. A wireless controller may have alternating-current magnetometers for monitoring the alternating-current field. The wireless controller may also have an accelerometer for measuring the orientation of the controller relative to the Earth's gravity and a direct-current magnetometer for measuring the orientation of the controller relative to the Earth's magnetic field. The alternating-current magnetometers may be three-coil magnetometers located at different locations in a controller housing. Using data from the alternating-current magnetometers, the direct-current magnetometer, the accelerometer, and/or other sensors, the wireless controller can determine the position and orientation of the wireless controller. This information can be wirelessly transmitted to the head-mounted device to control the head-mounted device.Type: ApplicationFiled: March 8, 2023Publication date: October 19, 2023Inventors: Yuhao Pan, Guangwu Duan, Jeffrey A. Griffis, John G. Elias, Krishna Prasad Vummidi Murali, Michael A. Lehr, Savas Gider, Stephen E. Dey
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Publication number: 20230285590Abstract: Polymer-cargo-complexes including cross-linked copolymers and cargo molecules bound to the copolymers by electrostatic interactions. The non-medical use thereof for transfection and to a kit including such polymer-cargo-complexes. The polymer-cargo-complexes for use in therapy, in particular for use in gene therapy or peptide/protein drug delivery. A method of preparing the polymer-cargo-complexes. A kit for preparing a polymer-cargo-complex of the invention.Type: ApplicationFiled: June 18, 2021Publication date: September 14, 2023Inventors: Sangeun LEE, Brigitta LORETZ, Claus-Michael LEHR, K.H. Anna HIRSCH
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Patent number: 11332726Abstract: The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.Type: GrantFiled: April 30, 2019Date of Patent: May 17, 2022Assignees: EBERHARD KARLS UNIVERSITÄT TÜBINGEN MEDIZINISCHE FAKULTÄT, HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBH FÜR DAS HELMHOLTZ-INSTITUT FÜR PHARMAZEUTISCHE FORSCHUNG SAARLAND (HIPS)Inventors: Michael Kormann, Lauren Mays Weddle, Claus-Michael Lehr, Brigitta Loretz, Emad Malaeksefat
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Publication number: 20220044259Abstract: Improved systems and methods for database management using data normalization and defragmentation techniques are provided. At least one exchange processor in communication with an exchange computer system receives market data from the exchange computer system, processes the market information, and transmits the market data to a master processor. The master processor receives the market data, processes the data using at least one normalization process to generate normalized data including an intra-day file and an archival file, and stores the intra-day file and the archival file in the master database. The master processor transmits the intra-day file and the archival file to the at least one regional processor.Type: ApplicationFiled: August 6, 2020Publication date: February 10, 2022Applicant: Maystreet, Inc.Inventors: Niall Douglas, Robert Leahy, Michael Lehr
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Publication number: 20200360524Abstract: The present invention relates to conjugates of aminoglycosides and terpenoids, in particular sesquiterpenoids. Furthermore, the present invention relates to nano-assemblies formed by the inventive conjugates and to a method for producing the conjugates and/or the nano-assemblies. The present invention also relates to the inventive conjugates and nano-assemblies for use in therapy, in particular for use in the treatment of infectious diseases. Particularly preferred embodiments of the present invention relate to farnesylated aminoglycosides and nano-assemblies thereof, in which farnesol and its derivatives do not only function as carrier for the aminoglycosides but do themselves have pharmaceutical activity upon cleavage of the conjugate, in particular quorum sensing inhibitory activity.Type: ApplicationFiled: June 8, 2018Publication date: November 19, 2020Applicant: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBHInventors: Duy-Khiet HO, Brigitta LORETZ, Claus-Michael LEHR
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Publication number: 20190376051Abstract: The present invention relates to a nucleotide-modified messenger RNA for the permanent correction of a genetic alteration on a DNA. The invention further relates to a nucleotide-modified messenger RNA in combination with a repair template. It also relates to a pharmaceutical composition. It finally relates to methods for the correction of a genetic alteration on a DNA.Type: ApplicationFiled: April 30, 2019Publication date: December 12, 2019Applicants: Eberhard Karls Universität Tübingen Medizinische Fakultät, Helmholtz-Zentrum für Infektionsforschung GmbH für das Helmholtz-Institut für PharmazeutischeInventors: Michael KORMANN, Lauren Mays WEDDLE, Claus-Michael LEHR, Brigitta LORETZ, Emad MALAEKSEFAT
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Patent number: 10496209Abstract: An electronic device can include a force and touch sensing system. In one embodiment, an input force sensor device of an electronic device is disclosed.Type: GrantFiled: November 14, 2017Date of Patent: December 3, 2019Assignee: Apple Inc.Inventors: Krishna Prasad Vummidi Murali, Hari Vasudevan, Michael A. Lehr, Wesley S. Smith
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Patent number: 10383950Abstract: The present invention relates to a carrier system, a carrier and a pharmaceutical composition comprising a pathogen entry protein or fragment thereof, which specifically binds to a molecule on the surface of a mammalian target cell of said pathogen and which is covalently linked to the surface of said carrier and at least one hydrophilic antipathogenic agent. It further relates to a method of manufacturing a carrier system and the carrier system or the pharmaceutical composition for the use as a medicament.Type: GrantFiled: August 14, 2015Date of Patent: August 20, 2019Assignee: HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH (DE/DE)Inventors: Claus-Michael Lehr, Hagar Ibrahim Labouta, Sarah Gordon, Arianna Castoldi, Sara Menina, Rebecca Geyer, Annika Kochut, Petra Dersch
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Publication number: 20180284936Abstract: An electronic device can include a force and touch sensing system. In one embodiment, an input force sensor device of an electronic device is disclosed.Type: ApplicationFiled: November 14, 2017Publication date: October 4, 2018Inventors: Krishna Prasad Vummidi Murali, Hari Vasudevan, Michael A. Lehr, Wesley S. Smith
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Publication number: 20170232114Abstract: The present invention relates to a carrier system, a carrier and a pharmaceutical composition comprising a pathogen entry protein or fragment thereof, which specifically binds to a molecule on the surface of a mammalian target cell of said pathogen and which is covalently linked to the surface of said carrier and at least one hydrophilic antipathogenic agent. It further relates to a method of manufacturing a carrier system and the carrier system or the pharmaceutical composition for the use as a medicament.Type: ApplicationFiled: August 14, 2015Publication date: August 17, 2017Applicant: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBHInventors: Claus-Michael LEHR, Hagar Ibrahim LABOUTA, Sarah GORDON, Arianna CASTOLDI, Sara MENINA, Rebecca GEYER, Annika KOCHUT, Petra DERSCH
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Patent number: 9671300Abstract: An electronic device may include one or more low-noise pressure sensors for measuring air pressure. The electronic device may include wireless communications circuitry for communicating with external devices also having pressure sensors. Pressure data gathered by an external device may be used as reference pressure data for the electronic device. For example, if both devices are located in the same building, both pressure sensors will detect similar pressure fluctuations due to doors opening and closing and temperature-control systems turning on and off. By subtracting the reference pressure data from the pressure data gathered by the electronic device, calibrated pressure data may be obtained and may be used to reliably detect vertical displacement changes of the electronic device. In other scenarios, the pressure data may be compared with the reference pressure data to determine whether the two devices are in the same room.Type: GrantFiled: March 16, 2015Date of Patent: June 6, 2017Assignee: Apple Inc.Inventors: Stuart K. Neubarth, Michael A. Lehr, David MacNeil, Henry H. Yang
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Publication number: 20160273986Abstract: An electronic device may include one or more low-noise pressure sensors for measuring air pressure. The electronic device may include wireless communications circuitry for communicating with external devices also having pressure sensors. Pressure data gathered by an external device may be used as reference pressure data for the electronic device. For example, if both devices are located in the same building, both pressure sensors will detect similar pressure fluctuations due to doors opening and closing and temperature-control systems turning on and off. By subtracting the reference pressure data from the pressure data gathered by the electronic device, calibrated pressure data may be obtained and may be used to reliably detect vertical displacement changes of the electronic device. In other scenarios, the pressure data may be compared with the reference pressure data to determine whether the two devices are in the same MOM.Type: ApplicationFiled: March 16, 2015Publication date: September 22, 2016Inventors: Stuart K. Neubarth, Michael A. Lehr, David MacNeil, Henry H. Yang
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Patent number: 9393218Abstract: The subject of this application is the use of film-forming polyurethanes that are used in hair care agents or mixtures of these polyurethanes with other polymers in pharmaceutical preparations for dermal or transdermal administration of active ingredients, as well as patches and pharmaceutical preparations that contain these hair care polyurethanes.Type: GrantFiled: December 22, 2006Date of Patent: July 19, 2016Assignee: EPINAMICS GMBHInventors: Ines Zurdo Schroeder, Patrick Franke, Stefan Bracht, Claus-Michael Lehr, Ulrich Schäfer
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Patent number: 9225392Abstract: A coil assembly is disclosed. The coil assembly includes a coil that is provided on a substrate. The coil includes a trace element that is wound on the substrate. The trace element includes an interior gap that extends or is present along at least a portion of the trace element. The interior gap is dimensioned to reduce a presence of eddy currents that would otherwise be generated when the coil is active to inductively transmit or receive signals.Type: GrantFiled: March 9, 2011Date of Patent: December 29, 2015Assignee: QUALCOMM IncorporatedInventors: Michael Lehr, Manjirnath Chatterjee, Dyke Shaffer, Eric Liu
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Patent number: 8712324Abstract: At least two devices are provided that can each form part of a system to inductively exchange power and data. One device is capable of inductively transmitting a power signal to a second device, and to receive feedback from the second device in order to regulate the power signal.Type: GrantFiled: June 4, 2009Date of Patent: April 29, 2014Assignee: QUALCOMM IncorporatedInventors: Mark Corbridge, Manjirnath Chatterjee, Michael Lehr, Allan Hessenflow, Stuart Neubarth, Jacob Rasco
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Publication number: 20130308256Abstract: A coil assembly is disclosed. The coil assembly includes a coil that is provided on a substrate. The coil includes a trace element that is wound on the substrate. The trace element includes an interior gap that extends or is present along at least a portion of the trace element. The interior gap is dimensioned to reduce a presence of eddy currents that would otherwise be generated when the coil is active to inductively transmit or receive signals.Type: ApplicationFiled: March 9, 2011Publication date: November 21, 2013Applicant: Hewlett-Packard Development Company, L.P.Inventors: Michael Lehr, Manjirnath Chatterjee, Dyke Shaffer, Eric Liu
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Patent number: 8437695Abstract: An inductive signal interface comprises a coil assembly including one or more inductive coils, a bridge circuit including a plurality of switches, and control circuitry. The control circuitry is configured to individually operate the plurality of switches to enable the inductive signal interface to dynamically switch between a power-transmit mode and a power receive mode.Type: GrantFiled: July 21, 2010Date of Patent: May 7, 2013Assignee: Hewlett-Packard Development Company, L.P.Inventors: Manjirnath Chatterjee, Michael Lehr, Dyke Shaffer