Abstract: Devices, systems and methods for the treatment of chronic inflammatory disorders that include an implantable microstimulator and an external charger/controller wherein the microstimulator is configured to operate using closed-loop feedback. The feedback for the microstimulator can be electrical activity of the vagus nerve and/or heart sensed by the microstimulator. The feedback can be used to modulate the stimulation duration, intensity, frequency, on-time and off-time.

Abstract: Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and/or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.

Abstract: Examples of the disclosure describe systems and methods for presenting virtual content on a wearable head device. In some embodiments, a state of a wearable head device is determined by minimizing a total error based on a reduced weight associated with a reprojection error. A view reflecting the determined state of the wearable head device is presented via a display of the wearable head device. In some embodiments, a wearable head device calculates a preintegration term based on the image data received via a sensor of the wearable head device and the inertial data received via a first IMU and a second IMU of the wearable head device. The wearable head device estimates a position of the device based on the preintegration term, and the wearable head device presents the virtual content based on the position of the device.

Abstract: The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof. The present invention is directed to monotherapy and combination treatments with anti-PVRIG antibodies and anti-PD-1 antibodies, in particular nivolumab, using stable liquid pharmaceutical formulations thereof.

Abstract: Novel peptoid oligomers are disclosed that have a formula represented by the following formula Ia or Ib: The peptoid oligomers are prepared as modulators of androgen receptor (AR), and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals, including humans, associated with unwanted or aberrant AR activity. The present peptoid oligomers are particularly valuable for the treatment of subjects with cancer.

Abstract: Systems and methods for processing intelligence of users captured through quantitative data collection are disclosed. In one embodiment, a method for processing intelligence captured through quantitative data collection may include: (1) receiving, by a data management computer program executed by a computer processor, user interaction data from an agent executed by a user electronic device; (2) determining, by the data management computer program and from the user interaction data, a path in a process being taken by a user of the user electronic device; (3) comparing, by the data management computer program, the path to an approved path; (4) identifying, by the data management computer program, a difference between the path and the approved path; (5) determining, by the data management computer program, an impact of the difference; and (6) outputting, by the data management computer program, the difference and the impact.

Abstract: Various embodiments comprise systems, methods, and apparatus for enabling dynamic configuration of devices using encumbered shared spectrum (e.g., CBSDs using CBRS) so as to operate these devices in accordance with a most preferred operator preference of a plurality of operator preferences currently available in view of current wireless operating conditions, such as impacted by overlapping/proximate incumbent or priority users of the shared spectrum, or other changes in spectrum available conditions. Various embodiments further provide for an efficient return of these devices to a most preferred operator preference or steady-state configuration.

Abstract: Apparatuses, systems, and methods are disclosed for an ultraviolet sanitation device. An apparatus includes an ultraviolet (“UV”) light emitter configured to emit UV light at a predefined wattage. The predefined wattage includes a wattage sufficient for ultraviolet germicidal irradiation. The apparatus includes a connector that corresponds to a connection port of a mobile device such that the UV light emitter is activated in response to the connector being connected to the connection port of the mobile device.

Abstract: The invention is directed to a toolless screw including a body portion which comprises a shaft portion and a screw portion which includes a shank portion and a tip portion. The shank portion includes at least two helical threads which extend off the shank either at different angles, different distances, or a combination thereof. The tip portion is positioned at an end of the shank portion and has a diameter which is less than the diameter of the shank portion and extends to a point. The body portion is integrated with a screw portion at the end of the shank portion which is opposite the end where the tip portion is positioned.

Abstract: The present application provides a method of analyzing protein binding sequence, a method of making sequencing library, and compositions for performing such methods, which employs a transposome complex.

Abstract: Disclosed herein is a haptic feedback device that includes a circuit board, a pressure sensor in operable communication with the circuit board, and a vibrator in operable communication with the circuit board. The vibrator is configured to vibrate when the pressure sensor senses pressure above a threshold pressure. The haptic feedback device includes a battery in operable communication with the circuit board. The circuit board, the vibrator, the pressure sensor and the battery are configured to be inserted into a wearable article such that when a wearer wears the wearable article the vibrator is configured to vibrate when the wearer is lying in the supine position. Further disclosed is a wearable sleep mask having a band for receiving the haptic feedback device, and a method of use thereof.

Abstract: A system and method for offer targeting is disclosed. According to one embodiment, a method for offer targeting may comprise: providing a plurality of offers and a plurality of groups, wherein each group comprises one or more accounts; maintaining an offer counter for each of the plurality of groups; and assigning the plurality of offers, in a predetermined order, to the plurality of groups by repeating the following steps: (1) assigning an offer to one or more groups, wherein the one or more groups are selected from groups that are pre-qualified for the offer based on a plurality of business rules, and the selection of the one or more groups is based at least in part on the offer counters of the one or more groups; (2) incrementing offer counters associated with the one or more groups; and (3) sorting the plurality of groups based on the incremented offer counters.

Abstract: The invention is directed to a toolless screw including a body portion which comprises a shaft portion and a screw portion which includes a shank portion and a tip portion. The shank portion includes at least two helical threads which extend off the shank either at different angles, different distances, or a combination thereof. The tip portion is positioned at an end of the shank portion and has a diameter which is less than the diameter of the shank portion and extends to a point. The body portion is integrated with a screw portion at the end of the shank portion which is opposite the end where the tip portion is positioned.

Abstract: Disclosed are systems, media, and methods for automatically and intelligently redesigning a web presence by: ingesting files of an existing web site; extracting content from the ingested files; surveying a user for user preferences; determining a style package based on the user preferences; selecting a web site skeleton from a plurality of preconfigured web site skeletons based on the user preferences, the web site skeleton having a plurality of hierarchical blocks; applying a machine learning system to rank the extracted content; populating the content into the hierarchy of blocks based on the rank; automatically generating a redesigned web site by applying the style package to the populated web site skeleton; and providing an interface allowing the user to edit the style package, the content, and the web site skeleton.

Abstract: Disclosed is a switching device for facilitating data communication between at least one initiator device and multiple target devices. The switching device includes at least one input port configured to receive data from the at least one initiator device. The at least one input port is communicatively coupled to at least one internal bus corresponding to the at least one initiator device. The switching device includes multiple output ports configured to transmit data to the multiple target devices. The multiple output ports are communicatively coupled to a multiple internal bus corresponding to the multiple target devices. The switching device includes at least one routing module communicatively coupled with each of the at least one input port and the multiple output ports. The at least one routing module is configured to route data from the at least one input port to at least one output port of the multiple output ports.

Abstract: The present application provides a method of analyzing protein binding sequence, a method of making sequencing library, and compositions for performing such methods, which employs a transposome complex.

Abstract: Novel peptoid oligomers are disclosed that have a formula represented by the following formula Ia or Ib: The peptoid oligomers are prepared as modulators of androgen receptor (AR), and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals, including humans, associated with unwanted or aberrant AR activity. The present peptoid oligomers are particularly valuable for the treatment of subjects with cancer.

Abstract: The present invention is a press molded custom foot plate, a method of making said plate, and a method of making a shoe using said press molded plate wherein said press molded foot plate is formed of a piece of press molded material that is incorporated and used as the insole of a shoe and where an outsole and uppers are attached to the press molded custom foot plate.