Patents by Inventor Michael A Lonetto

Michael A Lonetto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds
    Patent number: 7422749
    Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: September 9, 2008
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Michael T. Black, Martin K. Burnham, Jason C. Fedon, John E. Hodgson, David J. Knowles, Michael A. Lonetto, Richard O. Nicholas, Leslie M. Palmer, Julie M. Pratt, Raymond W. Reichard, Martin Rosenberg, Christopher M. Traini, Judith Ward, Richard L. Warren
  • Novel compounds
    Publication number: 20080076709
    Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
    Type: Application
    Filed: January 25, 2007
    Publication date: March 27, 2008
    Applicant: Affinium Pharmaceuticals, Inc.
    Inventors: Michael Black, Martin Burnham, Jason Fedon, John Hodgson, David Knowles, Michael Lonetto, Richard Nicholas, Leslie Palmer, Julie Pratt, Raymond Reichard, Martin Rosenberg, Christopher Traini, Judith Ward, Richard Warren
  • Purified polypeptides from streptococcus pneumoniae
    Publication number: 20070009546
    Abstract: The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: April 13, 2006
    Publication date: January 11, 2007
    Inventors: Michael Black, John Hodgson, David Knowles, Michael Lonetto, Richard Nicholas, Robert Stodola, Martin Burnham
  • Novel compounds
    Publication number: 20060083752
    Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
    Type: Application
    Filed: June 23, 2005
    Publication date: April 20, 2006
    Applicant: Affinium Pharmaceuticals, Inc.
    Inventors: Michael Black, Martin Burnham, Jason Fedon, John Hodgson, David Knowles, Michael Lonetto, Richard Nicholas, Leslie Palmer, Julie Pratt, Raymond Reichard, Martin Rosenberg, Christopher Traini, Judith Ward, Richard Warren
  • Novel xanthine phosphoribosyl transferase
    Publication number: 20050032161
    Abstract: The invention provides xanthine phosphoribosyl transferase polypeptides and DNA (RNA) encoding xanthine phosphoribosyl transferase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing xanthine phosphoribosyl transferase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: April 5, 2004
    Publication date: February 10, 2005
    Inventors: Michael Black, John Hodgson, David Knowles, Michael Lonetto, Richard Nicholas, Robert Stodola, Martin Burnham
  • lacR from Streptococcus pneumoniae
    Patent number: 6548273
    Abstract: The invention provides lacR polypeptides and polynucleotides encoding lacR polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing lacR polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: April 15, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Pan Fong Chan, David J. Holmes, Michael A. Lonetto, Christopher M. Traini, Magdalena Zalacain
  • Fucose kinase
    Patent number: 6511839
    Abstract: The invention provides fucose kinase promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: January 28, 2003
    Inventors: Pan Fong Chan, Sanjoy Biswas, David J. Holmes, Michael A. Lonetto, Leslie M. Palmer, Stephanie Van Horn, Richard L. Warren, Jr., Magdalena Zalacain
  • Novel human polypeptide deformylase (PDF)
    Publication number: 20020137158
    Abstract: PDF polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PDF polypeptides and polynucleotides in diagnostic assays.
    Type: Application
    Filed: May 25, 2001
    Publication date: September 26, 2002
    Inventors: Xiaotong Li, Michael A. Lonetto, Christopher D. Southan, Yuan Zhu
  • galK
    Publication number: 20020107217
    Abstract: The invention provides galK promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.
    Type: Application
    Filed: September 17, 2001
    Publication date: August 8, 2002
    Inventors: Pan Fong Chan, David J. Holmes, Michael A. Lonetto, Stephanie Van Horn, Richard L. Warren, Magdalena Zalacain
  • yacM1
    Publication number: 20020064863
    Abstract: The invention provides yacM1 polypeptides and polynucleotides encoding yacM1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing yacM1 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and materials.
    Type: Application
    Filed: June 7, 2001
    Publication date: May 30, 2002
    Inventors: Martin K. Burnham, David J. Holmes, Michael A. Lonetto, Robert D. Lunsford, Damien McDevitt, Daniel Sylvester, Stephanie Van Horn, Magdalena Zalacain
  • defl
    Publication number: 20020058796
    Abstract: The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 21, 2001
    Publication date: May 16, 2002
    Inventors: Michael A. Lonetto, David J. Holmes, Deborah D. Jaworski, Richard O. Nicholas, Min Wang, Robert K. Stodola, Anna L. Kosmatka, Richard L. Warren, David J.C. Knowles, Christopher M. Traini, John E. Hodgson
  • ama
    Publication number: 20020052472
    Abstract: The invention provides ama polypeptides and polynucleotides encoding ama polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ama polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: January 12, 2001
    Publication date: May 2, 2002
    Inventors: David T. Beattie, Robert L. Deresiewicz, Adrian M. Lowe, Michael A. Lonetto, John E. Hodgson, Richard O. Nicholas, Leslie Marie Palmer, Julie M. Pratt
  • TktA from Streptococcus pneumoniae
    Patent number: 6326167
    Abstract: The invention provides tktA polypeptides and polynucleotides encoding tktA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tktA polypeptides and polynucleotides to screen for antibacterial compounds and for the detection of Streptococcus pneumoniae.
    Type: Grant
    Filed: April 23, 1999
    Date of Patent: December 4, 2001
    Assignee: SmithKline Beecham Corp.
    Inventors: Alison F Chalker, Sauli J Haataja, David W Holden, David J Holmes, Karen A Ingraham, Gee W Lau, Andrea Marra, Michael A Lonetto, Damien McDevitt, Jennifer Ray, Jun Yu
  • Galk promoter
    Patent number: 6291230
    Abstract: The invention provides galK promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: September 18, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc,
    Inventors: Magdalena Zalacain, Pan Fong Chan, David J. Holmes, Michael A. Lonetto, Stephanie Van Horn, Richard L. Warren, Jr.
  • Ribosome recycling factor (FRR) of Staphylococcus aureus
    Patent number: 6238887
    Abstract: This invention provides frr polypeptides and polynucleotides encoding frr polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing frr polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: May 29, 2001
    Assignees: Brigham & Women's Hospital, Virus Research Institute, SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: David T Beattie, Robert L Deresiewicz, Adrian M Lowe, Michael A Lonetto, John E Hodgson, Richard O Nicholas, Leslie Marie Palmer, Julie M Pratt
  • UDP-N-acetylmuramoyl-l-alanine:D-glutamate ligase (MURD) of staphylococcus aureus
    Patent number: 6211161
    Abstract: The invention provides murD polypeptides and polynucleotides encoding murD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing murD polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: April 3, 2001
    Assignees: Brigham & Women's Hospital, Virus Research Institute, SmithKline Beecham Corporation, SmithKline Beecham plc,
    Inventors: David T Beattie, Robert L Deresiewicz, Adrian M Lowe, Richard O Nicholas, Leslie Marie Palmer, Julie M Pratt, Michael A Lonetto, John E Hodgson
  • Ama
    Patent number: 6197549
    Abstract: This invention provides ama polypeptides and polynucleotides encoding ama polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ama polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: March 6, 2001
    Assignees: Brigham & Women's Hospital, Virus Research Institute, SmithKline Beecham Corporation, SmithKline Beecham, plc
    Inventors: Richard O Nicholas, Leslie Marie Palmer, Julie M Pratt, David T. Beattie, Robert L Deresiewicz, Adrian M Lowe, Michael A Lonetto, John E Hodgson
  • Staphylococcus aureus 3-hydroxyacyl-CoA dehydrogenase
    Patent number: 6146863
    Abstract: The invention provides hcd polypeptides and polynucleotides encoding Staphylococcus aureus 3-hydroxyacyl-CoA dehydrogenase (hcd) polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing hod polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 18, 1999
    Date of Patent: November 14, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Leslie Marie Palmer, Michael A Lonetto, Richard O Nicholas, Robert L Deresiewicz, Julie M Pratt, John E Hodgson, David T Beattie, Adrian M Lowe
  • ClpL
    Patent number: 6126937
    Abstract: The invention provides clpL polypeptides, polynucleotides encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: October 3, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc, Virus Research Institute, Brigham & Women's Hospital
    Inventors: David T Beattie, Robert L Deresiewicz, Adrian M Lowe, Michael A Lonetto, John E Hodgson, Richard O Nicholas, Leslie Marie Palmer, Julie M Pratt