Abstract: The present invention relates to trigonal GLP-1/glucagon/GIP receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.

Abstract: The present invention relates to trigonal GLP-1/glucagon/GIP receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.

Abstract: The invention relates to polyphenyl polymethylene polyisocyanates having an NCO number of at least 29% comprising less than 2% by weight ureas, less than 8% by weight carbodiimides or uretonimines and less than 1000 ppm organic chlorine compounds. The polyphenyl polymethylene polyisocyanates can be prepared according to the invention by reacting (i) polyphenyl polymethylene polyamines with organic carbonates to give the corresponding polyphenyl polymethylene polycarbamates, (ii) by thermally cleaving the polyphenyl polymethylene polycarbamates to give the polyphenyl polymethylene polyisocyanates, wherein, prior to the thermal cleavage, the free amino groups or urea groups present in the carhamate crude mixture comprising the polyphenyl polymethylene polycarbamates are reacted with a derivatizing reagent to give amide groups or urethane groups.

Abstract: The present invention relates to a method of bonding two substrates of titanium aluminide alloy at a faying surface, comprising the steps of applying a braze material of a titanium alloy consisting of from 10 to 35 at. % aluminum, from 5 to 30 at. % iron and/or nickel, and optionally other alloying elements present in the substrate material in quantities (at. %) up to their content in the substrate material, the remainder being titanium, at the faying surface of the substrates, and subjecting the substrates and braze material to an elevated temperature above the melting point of the braze material and below ?-solvus temperature of the ?-titanium aluminide alloy, and joining the substrates by transient liquid phase bonding.

Abstract: The present invention relates to a method of bonding at a faying surface two substrates of ?-titanium aluminide alloy having a ?-single phase region at elevated temperatures, comprising the steps of applying a braze material of a titanium alloy consisting of from 10 to 35 at. % aluminum, from 5 to 30 at. % iron and/or nickel, and optionally other alloying elements present in the substrate material in quantities (at. %) up to their content in the substrate material, the remainder being titanium, at the faying surface of the substrates, and subjecting the substrates and braze material to an elevated temperature in the ?-single phase region of the substrate, and joining the substrate at the crack interface by transient liquid phase bonding.

Abstract: An optical arrangement, in particular a lithography system, includes: a movable component, in particular a mirror; at least one actuator for moving the component; and at least one stop having a stop face for delimiting the movement of the component. The optical arrangement further includes, on a stop or on a plurality of stops, at least two stop faces for delimiting the movement of the movable component in one and the same movement direction.

Abstract: An inductive power receiving device configured to: supply power received with a power receiving coil to a load in a first mode; determine whether a converter voltage exceeds a threshold voltage; in response to the determining the converter voltage exceeds the threshold voltage after sending a charging mode request, switch to supplying power received with the power receiving coil to the load in a second mode; and in response to determining the converter voltage coil exceeds the threshold voltage before sending the charging mode request is sent, prevent at least a portion of the power received with the power receiving coil from reaching the load. An inductive power transmitting device configured to provide an alternating current voltage to a power transmitting coil and gradually increase the voltage after receiving a charging mode request and stop gradually increasing the voltage once an inductive power receiving device changes modes.

Abstract: An integrated actuator coil and decoder module for use in decoder-based irrigation control systems, and related methods of manufacture and installation, are provided herein. In one implementation, an irrigation control device comprises a body, decoder circuitry located within the body, a coil located within the body and coupled to the decoder circuitry, the coil adapted to develop an electromagnetic flux sufficient to cause actuation of a device controlling irrigation equipment in response to signaling from the decoder circuitry. Also included is an electrical connection coupled to the decoder circuitry and adapted to couple to a control wire path of a decoder-based irrigation control system. The decoder circuitry and the coil are integrated into a single device.

Abstract: The present invention relates to a new method for enriching and/or isolating nucleic acids from microbial cells which comprises filtering a liquid sample through a nucleic acid-binding matrix which has a pore size small enough to retain microbial cells, lysing the microbial cells on the matrix to release the nucleic acids from the microbial cells, binding the nucleic acids to the matrix and subsequently eluting the DNA. The invention also relates to a method for enriching and/or isolating nucleic acids from microbial cells which are present in a liquid sample that comprises microbial cells and higher eukaryotic cells and/or tissues. The invention also provides a cartridge for carrying out the methods of the invention. Finally, the invention relates to kits for carrying out the methods of the invention.

Abstract: An optical imaging arrangement includes an optical element unit, and an actuator device connected to the optical element unit and is configured to be connected to a support structure for supporting the optical unit. The actuator device is configured to: actively adjust, in an adjustment state, a position and/or an orientation of the optical unit with respect to the support structure in N degrees of freedom; and support the optical element unit in a statically overdetermined manner in at least one of the N degrees of freedom via a plurality of active first and second actuator components such that, in a holding state following the adjustment state, the first and second actuator components cause a parasitic residual load introduced into the optical element unit in the at least one of the N degrees of freedom.

Abstract: The invention relates to an access device comprising: a base (1) for aligning the access device with the skin of a patient; a needle for puncturing the skin, the needle comprising a hub (2) and a cannula (10), and the needle being movably mounted in the base (1) such that it can move between a first, fully retracted, and a second, maximally extended, position; and a locking mechanism which engages when the needle retracts from the second position and reaches a discrete third position, inhibiting the needle from further retracting to the first position. According to the invention, the access device is actuatable to disengage the locking mechanism.

Abstract: An integrated actuator coil and decoder module for use in decoder-based irrigation control systems, and related methods of manufacture and installation, are provided herein. In one implementation, an irrigation control device comprises a body, decoder circuitry located within the body, a coil located within the body and coupled to the decoder circuitry, the coil adapted to develop an electromagnetic flux sufficient to cause actuation of a device controlling irrigation equipment in response to signaling from the decoder circuitry. Also included is an electrical connection coupled to the decoder circuitry and adapted to couple to a control wire path of a decoder-based irrigation control system. The decoder circuitry and the coil are integrated into a single device.

Abstract: An object-based data storage system includes a memory and a processor for executing machine executable instructions configured for implementing logical containers for data objects each having a global identifier. The containers are configured for storing metadata including a first parameterization value descriptive of a number of storage nodes and a second parameterization value descriptive of a classification of the data objects. The machine executable instructions are further configured for implementing a first object storage ring for addressing storage locations across the multiple storage nodes using a surjective function.

Abstract: A rear suspension for a vehicle includes a knuckle for supporting a rear wheel of the vehicle, and the knuckle defines an opening. The rear suspension system further includes two suspension devices configured to be connected to the vehicle and an upper portion of the knuckle, such that each suspension device is oriented along an upright axis when the rear suspension system is mounted on the vehicle. In addition, the rear suspension system includes a control arm having a first portion configured to be connected to the vehicle and a second portion configured to extend between the axes of the suspension devices and into the opening of the knuckle when the rear suspension system is mounted on the vehicle.

Abstract: The present invention relates to a device (2) for determining an optimal placement of a pedicle screw (4), comprising a processing unit (14), wherein the processing unit is configured to receive a model data set representing a model surface (22) of a human vertebra model (18) and a pedicle screw model (30) being optimally placed in a span of a pedicle section (28) of the model surface, wherein the processing unit is configured to receive 5 image data representing a surface image (26) of at least one human vertebra (6), GO and wherein the processing unit is configured to adapt the model data set for each of a number of the at least one human vertebra, such that an adapted model data set representing a correspondingly adapted model surface (36), which fits to the surface image of the respective human vertebra, is provided for each of the number of the at least one human vertebra, wherein each of the 10 adapted model data sets also represents a correspondingly adapted pedicle screw model (38).

Abstract: An optical imaging arrangement includes an optical element unit, and an actuator device connected to the optical element unit and is configured to be connected to a support structure for supporting the optical unit. The actuator device is configured to: actively adjust, in an adjustment state, a position and/or an orientation of the optical unit with respect to the support structure in N degrees of freedom; and support the optical element unit in a statically overdetermined manner in at least one of the N degrees of freedom via a plurality of active first and second actuator components such that, in a holding state following the adjustment state, the first and second actuator components cause a parasitic residual load introduced into the optical element unit in the at least one of the N degrees of freedom.

Abstract: An integrated irrigation valve control device has a coil adapted to develop an electromagnetic flux sufficient to cause actuation of irrigation equipment. Control circuitry is electrically coupled to the coil to control the flux at the coil. A housing covers at least a portion of the coil and at least a portion of the control circuitry.

Abstract: The present invention relates to a reactor R with apparatus D, the latter comprising a gas- and/or liquid-permeable tray B, in the edge region of which there is disposed a lateral boundary W which fully encloses the tray B and forms a volume V comprising catalytic and/or noncatalytic shaped bodies (F), wherein there is at least one braid made of precious metal and/or base metal on the upstream side opposite the tray B, and the catalytic and/or noncatalytic shaped bodies (F) are selected from (i) shaped bodies (F1) in the form of straight prisms, the footprint of which is selected from triangle, rectangle, hexagon or fragments of these polygons, and (ii) a combination of the shaped bodies (F1) with shaped bodies (F2) that are smaller than the shaped bodies (F1), wherein groups of m to n shaped bodies (F1), m and n being an integer from 3 to 30 with n>m, are framed in a metal cassette open in the upstream direction and closed in the downstream direction by a gas-permeable tray, in a virtually seamless manner

Abstract: An integrated irrigation valve control device has a coil adapted to develop an electromagnetic flux sufficient to cause actuation of irrigation equipment. Control circuitry is electrically coupled to the coil to control the flux at the coil. A housing covers at least a portion of the coil and at least a portion of the control circuitry.