Patents by Inventor Michael A. Malfatti

Michael A. Malfatti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for central reactivation of organophosphorus-based compound-inhibited acetylcholinesterase and/or inactivation of organophosphorus-based acetylcholinesterase inhibitors and related compositions methods and systems for making and using them
    Patent number: 11186548
    Abstract: Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: November 30, 2021
    Assignee: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
    Inventors: Carlos A. Valdez, Nicholas A. Be, Michael A. Malfatti, Heather Ann Enright, Brian J. Bennion, Timothy S. Carpenter, Saphon Hok, Hio Leong Lao, Tuan H. Nguyen
  • Cytotoxic Chemotherapy-Based Predictive Assays for Acute Myeloid Leukemia
    Publication number: 20200010910
    Abstract: The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient or a sample from the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.
    Type: Application
    Filed: July 10, 2019
    Publication date: January 9, 2020
    Inventors: Paul Henderson, George D. Cimino, Maike Zimmermann, Michael A. Malfatti, Kenneth W. Turteltaub, Ralph W. De Vere White, Brian Jonas, Tiffany Scharadin, Chong-Xian Pan
  • COMPOUNDS FOR CENTRAL REACTIVATION OF ORGANOPHOSPHORUS- BASED COMPOUND-INHIBITED ACETYLCHOLINESTERASE AND/OR INACTIVATION OF ORGANOPHOSPHORUS-BASED ACETYLCHOLINESTERASE INHIBITORS AND RELATED COMPOSITIONS METHODS AND SYSTEMS FOR MAKING AND USING THEM
    Publication number: 20190152920
    Abstract: Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.
    Type: Application
    Filed: November 21, 2018
    Publication date: May 23, 2019
    Inventors: Carlos A. Valdez, Nicholas A. Be, Michael A. Malfatti, Heather Ann Enright, Brian J. Bennion, Timothy S. Carpenter, Saphon Hok, Hio leong Lao, Tuan H. Nguyen