Abstract: A method may include applying a protein sequence computation model to generate, based on an input protein sequence, a plurality of proposed protein sequences. A set of possible amino acid residues for each position in at least a portion of an output protein sequence may be identified based on the plurality of proposed protein sequences. A first protein structure having the output protein sequence may be generated by applying a protein structure computation model to select, for each position in at least the portion of the output protein sequence, an amino acid residue from a corresponding set of possible amino acid residues. The protein structure computation model may further determine the conformation of the amino acid residues selected for inclusion in the output protein sequence. In some cases, the first protein structure may be grafted onto a second protein structure to form a third protein structure.

Abstract: A system comprising one or more computing devices implements a vehicle information extraction service. The vehicle information extraction service enables customers to maintain a model of a fleet of vehicles and collect vehicle information from heterogenous vehicles included in the fleet, wherein the vehicles are configured with different in-vehicle communication configurations. The vehicle information extraction service automatically generates scheme packets for data collection to be sent to the heterogenous vehicles, wherein are formatted in accordance with the different respective in-vehicle communication configurations of the heterogenous vehicles, without the customer of the vehicle information extraction service having to account for these differences.

Abstract: A computer system for validating trays loaded with products receives at least one image of products in at least one tray of a plurality of trays in an imaging area. A type of the products in the at least one tray is determined based upon the at least one image. The type of products in the at least one tray is compared to at least one order. A confirmation or error is indicated based upon the comparison. In some examples, the products are bakery products of different types loaded in plastic, stackable bakery trays. In one example method, a plurality of stacks of loaded bakery trays are imaged from a front or rear of the trays. In another example method, the plurality of stacks are imaged from overhead as the trays are loaded onto the stacks.

Abstract: Suture passer systems for tissue suspension and tissue compression, and more particularly for tongue suspension, are described. The system can include at least a first elongate tubular body or shaft, a needle having a lateral bias carried by the elongate body, and a retrieval element operably connected to the elongate tubular body. The needle can have a substantially straight configuration when located within the elongate tubular body, and be configured to exit an opening at or near a distal end of the elongate tubular body and assume a laterally biased or curved shape to form a path through tissue. The needle is configured to carry a suture. The retrieval element can be configured to retrieve the suture carried by the needle after the needle has formed a curved or otherwise angled path through tissue. The system can also include one or more bone anchors to secure the suture loops. Methods of placing one or more suture loops into tissue, such as the base of the tongue, are also described.

Abstract: A knife comprising a handle and a blade assembly. The blade assembly includes a blade, a tang, and blade assembly connection structure. The handle includes a receiver configured to receive the tang, and includes handle connection structure. The blade assembly connection structure and handle connection structure are arranged to releasably lock the blade assembly in an installed position on the handle with the tang in the tang receiver.

Abstract: A transport assembly with an upper part including a plurality of sleeves, each sleeve extending along a sleeve axis between a top opening and a bottom opening, wherein the plurality of sleeves are arranged with their respective axes in parallel to one another, and a lower part including a plate with a plurality of apertures that each extend through the plate. The upper part and the lower part can be coupled such that each bottom opening is arranged adjacent to one of the plurality of apertures, and the upper part and the lower part can be moved relative to one another between a closed configuration in which a perimeter of each bottom opening intersects a perimeter of a corresponding aperture at two or more points, and an open configuration in which the perimeter of each bottom opening is aligned with or is enclosed by the perimeter of a corresponding aperture.

Abstract: The present disclosure provides methods and compositions related to the modification of immune effector cells to increase therapeutic efficacy. In some embodiments, immune effector cells modified to reduce expression of one or more endogenous target genes, or to reduce one or more functions of an endogenous protein to enhance effector functions of the immune cells are provided. In some embodiments, immune effector cells further modified by introduction of transgenes conferring antigen specificity, such as exogenous T cell receptors (TCRs) or chimeric antigen receptors (CARs) are provided. Methods of treating a cell proliferative disorder, such as a cancer, using the modified immune effector cells described herein are also provided.

Abstract: A connected ecosystem for a laboratory environment comprises an electronic lab notebook, and instrumented biosafety cabinet, and one or more sensing vessels containing cell cultures. The electronic lab notebook interfaces with the instrumented biosafety cabinet to provide instructions, guidance, and monitoring of a user during the set up of the experimental protocol and to receive commands from the user via one of several input modalities. After the experimental protocol has been set up in the instrumented biosafety cabinet, cell cultures may be moved to an incubator where the connected ecosystem may provide automatic monitoring of the cultures. The automatic monitoring is provided by sensors integrated into cell culture vessels and supplemented by images of the cell cultures captured by a camera. The user may be informed of deviations from expected results detected based on the automatic monitoring.

Abstract: A utility vehicle includes an exhaust assembly fluidly coupled to an engine. Depending on various parameters, such as the size and/or performance of the vehicle, the exhaust assembly is required to meet certain emissions regulations. Such emissions regulations may be met by increasing the temperature within the exhaust assembly, however, at particularly high temperatures, a catalyst of the exhaust assembly may be damaged. Therefore, the exhaust assembly includes various options for cooling portions thereof to remove heat from the assembly.

Abstract: A drive train for a vehicle includes an internal combustion engine (VM) coaxial to the first axis (A1), at least one first electric machine (EM1) and one second electric machine (EM2), and a transmission arrangement (G) connectable to an output (Ab). The first electric machine (EM1) has larger dimensions than the second electric machine (EM2). The second electric machine (EM2) is connectable at least to the internal combustion engine (VM), and the first electric machine (EM1) is connectable at least to the transmission arrangement (G). The first electric machine (EM1) and the second electric machine (EM2) are coaxial to the first axis (A1). The first electric machine (EM1) and the second electric machine (EM2) are radially nested, or the first electric machine (EM1), when viewed axially, is associated with the internal combustion engine and the second electric machine (2), when viewed axially, is associated with the output.

Abstract: A method of forming a composite part from a mufti-ply prepreg composite charge comprises reducing pressure inside a bladder, located in a chamber that is at atmospheric pressure, below the atmospheric pressure. The method also comprises placing the multi-ply prepreg composite charge, having a first shape, in the chamber and reducing pressure inside the chamber below the atmospheric pressure. The method additionally comprises, while maintaining pressure inside the chamber below the atmospheric pressure, expanding the bladder within the chamber by increasing pressure inside the bladder to the atmospheric pressure, so that the multi-ply prepreg composite charge is compressed between the bladder and a forming tool, which is located inside the chamber, and the multi-ply prepreg composite charge is configured by the forming tool to a second shape, different from the first shape. The method also comprises curing the multi-ply prepreg composite charge, having the second shape.

Abstract: The present invention relates generally to a closure system for use in surgical procedures.

Abstract: Systems, computer-implemented methods, and computer program products to facilitate evaluation of quantum circuit optimization routines and knowledge base generation are provided. According to an embodiment, a system can comprise a processor that executes computer executable components stored in memory. The computer executable components can comprise a compilation component that concurrently executes different quantum circuit optimization sequences on multiple copies of a quantum circuit. The computer executable components can further comprise an identification component that identifies at least one of the different quantum circuit optimization sequences that generates an output quantum circuit comprising defined criteria.

Abstract: A method receives an input file. The input file includes a plurality of entries where different entries are associated with a different characteristic. A selection of a guide for an entry is determined where a guide includes guidelines for formatting content in an entry in the plurality of entries. The method performs analyzing an image from the entry to generate image variations. Then, the method analyzes the image and the image variations to place text items from the entry in the image and the image variations where the text items in the image and the image variations are formatted based on the guidelines in the guide for the entry. A plurality of design variants is generated for the entry based on the image and the image variations that include text items.

Abstract: A security enclosure, components thereof, and associated methods. In one embodiment, the security enclosure is sized and shaped to hold a firearm, and the security enclosure can be used with a monitor and an associated magnet. The security enclosure system includes first and second enclosure portions movable with respect to one another to open and close the system. The first enclosure portion includes a first holder, the second enclosure portion includes a second holder, and at least one of the first or second holders holds the security monitor in an interior when the enclosure is closed. The other of the at least one of the first or second holders holds the magnet in the interior when the enclosure is closed. The first and second holders are adjacent to each other when the enclosure is closed and are spaced apart from each other when the enclosure is open.

Abstract: Various embodiments herein relate to machinery for forming smoking articles of cannabis compositions. In at least one embodiment, there is provided a system for alcohol-based lubrication for pre-roll machinery comprising: a reservoir tank for retaining lubricant fluid; a tube conduit having a first end fluidically coupled to the reservoir tank and an open second end; and a modified pre-roll member having a fluid-receiving opening coupled to the second tube end, the modified pre-roll member further comprising a bottom contact surface including one or more fluid exit openings coupled to the fluid-receiving opening.

Abstract: A first compute server of a plurality of compute servers of a distributed cloud computing network receives an inference request. The first compute server determines that the received inference request triggers execution of code at the distributed cloud computing network, where the code is related to an artificial intelligence (AI) application that interacts with the inference request and causes input of the inference request to be run through an AI model. If the AI model is not loaded at the first compute server but is loaded at a second compute server, the inference request is routed to the second compute server for performing the inference operation.

Abstract: An electric machine with a low profile retention assembly for retention of a stator core is disclosed. A first housing houses the stator core. The first housing has an axial end face with a circumferentially extending, shaped profile having recessed portions that project axially inward alternating with non-recessed portions. A portion of the stator core extends axially out from the recessed portions. A core retention spring is disposed circumferentially at the axial end face of the first housing. The core retention spring has direct contact with the portion of the stator core that extends axially out from the recessed portions of the first housing and the shaped profile of the housing. The core retention spring pushes against the portion of the stator core that extends that extends axially out from the first housing, imparting one or more of an axial load and radial load into the stator core.

Abstract: Methods and systems for automatically predicting the probability of regulatory compliance approval based on data contained in a data structure. A data structure can be configured to include data collated and collected from one or more regulators (e.g., regulatory agencies) and one or more value chain participants. Such data is inclusive of data indicative of actual approval-request results of applications for regulatory approval by one or more regulators and variable weights assigned to different data elements. A prediction can be then made as to the probability that an application for regulatory approval by a value chain participant will be approved by a regulator based on the data collated and collected and contained in the data structure. This approach predicts the probability that an application for regulatory approval by a value chain participant will be approved and also predicts what is missing for a regulatory approval application.