Abstract: Fire spikes and fire spike tips adapted to penetrate a surface and distribute a fire suppressant, such as, water, on the opposite side of the surface are provided. The fire spike tips include a cylindrical body having a first end adapted to be received by a conduit and a second end having a pointed projection adapted to penetrate the surface; an internal cavity in the cylindrical body having an open first end and a closed second end; a plurality of first orifices in the body, each of the plurality of first orifices directed in a first substantially radial direction; and a plurality of second orifices in the body, each of the plurality of second orifices directed in a second direction which at least partially intersects with the first direction of the plurality of first orifices. Kits for the fire spikes and methods of suppressing fire are also provided.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: Detection and identification of auditory events in distributed lighting networks is provided. Lighting fixtures or other devices in a distributed lighting network can incorporate an audio sensor (e.g., a microphone) through which auditory events (e.g., air leaks in compressed air systems, high noise events, shots fired, clapping, voice commands, etc.) are detected and measured. Through machine learning (e.g., a convolutional neural network), a type of auditory event can be identified, and action can be taken based on the type of the auditory event, such as to provide notification, alert nearby users, log events, provide sound cancelation, and so on. In some examples, the auditory event can be localized using multiple audio sensors. In some examples, a learning algorithm can fuse information from multiple sensor inputs, such as temperature sensors, cameras, occupancy sensors, light sensors, and so on.

Abstract: A milling machine, system, and method for implementing a return to cut operation and/or an exit cut operation controls legs of the milling machine, a rotor of the milling machine, and front and rear doors of a mixing chamber of the milling machine according to settings for each of the return to cut operation and the exit cut operation. Such control can be based on signals from one or more sensors of the milling machine configured to sense various position-related characteristics of the milling machine, and can be performed responsive to a control input at an operator control interface of the milling machine.

Abstract: An apparatus for mixing and dispensing viscous food products is described herein. The apparatus may include a pump device for drawing the viscous food product from a container and distributing over a rotating turntable. The apparatus includes a cassette device with replaceable pliable food containers connected to the pump device through a friction-fit connection. The cassette device includes a sliding roller assembly and a door, with the container installed between the sliding roller assembly and the door such that the roller assembly applies force against the door and container as the sliding roller assembly descends under gravity. The sliding roller assembly includes level indicators visible through the door that provide visual indication of the level of food product remaining within the container.

Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: Computer implemented systems and methods for providing dynamic lighting through lighting fixtures are provided herein. In one aspect, one or more characteristics of light provided from a lighting fixture or a plurality of lighting fixtures changes over time to shape the environment of an indoor space according to simulated environment illumination parameters and general illumination parameters. Dynamic lighting may improve the health or wellbeing of individuals in an indoor space, for example, by simulating an outdoor environment to reduce stress, by providing circadian entrainment to improve sleep and wakefulness, or the like. Other aspects of the present disclosure enable lighting fixtures to provide light that is synchronized with one or more other devices that simulate an environment and shape the environment of an indoor space.

Abstract: The invention provides methods of using environmentally compatible detergents in the field of recombinant protein manufacturing for inactivating viruses in a product feedstream in the manufacturing process of proteins intended for administration to a patient, such as therapeutic or diagnostic proteins. The invention further provides methods wherein the environmentally compatible detergent used in the present invention maintains product quality of the therapeutic or diagnostic protein whilst effectively inactivating viruses.

Abstract: Systems and methods for providing dynamic lighting are provided. In an exemplary aspect, one or more characteristics of light provided from a lighting device or a group of lighting devices changes over time to shape the environment of an indoor space according to dynamic lighting instructions. Dynamic lighting may improve the health or wellbeing of individuals in an indoor space, for example, by simulating an outdoor environment to reduce stress, by providing circadian entrainment to improve sleep and wakefulness, or the like. Other aspects of the present disclosure enable lighting devices to provide light that is synchronized with one or more other devices and does not significantly drift over time so that the lighting devices can provide seamless dynamic lighting experiences that shape the environment of an indoor space.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

Abstract: An apparatus for mixing and dispensing viscous food products is described herein. The apparatus may include a pump device for drawing the viscous food product from a container and distributing over a rotating turntable. The apparatus includes a cassette device with replaceable pliable food containers connected to the pump device through a friction-fit connection. The cassette device includes a sliding roller assembly and a door, with the container installed between the sliding roller assembly and the door such that the roller assembly applies force against the door and container as the sliding roller assembly descends under gravity. The sliding roller assembly includes level indicators visible through the door that provide visual indication of the level of food product remaining within the container.

Abstract: A level that is attached to the drill bit. It is on a bar that allows the level to be offset from the drill bit so that it is visible by the operator. The bar has a bearing in it that allows the bit to spin freely while holding the level in a set position. The level has a ball that centers in a ring when it is level and plumb. To use the device, after it is installed in a drill, the operator adjusts the position of the drill until the ball is in the center of the ring. Then, the drill bit is plumb and the hold will be true. The operator merely has to watch the level and adjust the drill as needed to maintain plumb to ensure a true hole.

Abstract: A modular tool apparatus includes at least one handle, at least one utility tool, at least one attachment channel, at least one pivot pin, and at least one lever. The pivot pin includes a D-shaped cross section and rotatably connected to the handle thus enabling the foldable connection between the handle and the utility tool. The lever is terminally connected to the pivot pin and allows the pivot pin to be configured in between a locked position and an unlocked position. The attachment channel laterally traverses into the utility tool as the attachment channel is rotatably engaged around the pivot pin. The utility tool is foldably attached to the handle through the attachment channel and the pivot pin, wherein the D-shaped cross section of the pivot pin and a matching profile of the attachment channel allow the utility tool to be installed or removed from the pivot pin.

Abstract: A milling machine, system, and method for implementing a return to cut operation and/or an exit cut operation controls legs of the milling machine, a rotor of the milling machine, and front and rear doors of a mixing chamber of the milling machine according to settings for each of the return to cut operation and the exit cut operation. Such control can be based on signals from one or more sensors of the milling machine configured to sense various position-related characteristics of the milling machine, and can be performed responsive to a control input at an operator control interface of the milling machine.

Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.