Abstract: In one aspect disclosed herein are small molecule inhibitors of CD38 and their use in treating, inhibiting, decreasing, reducing, ameliorating and/or preventing graft versus host disease, ischemia reperfusion injury, graft rejection, inflammatory injury to a graft or a graft recipient. Additionally, disclosed herein are methods of inhibiting CD38 pathway and activity comprising contacting a cell expressing CD38 or administering to a subject in need of CD38 inhibition, any of the small molecule CD38 inhibitors disclosed herein.

Abstract: Compression devices for joining tissue and methods for using and fabricating the same.

Abstract: A computer-implemented method for effectively delivering notifications in data storage environments includes, receiving, by a storage controller from a host system, a request to register the host system with the storage controller to receive notifications. These notifications may be associated with a selected type of event detected by the storage controller. In certain embodiments, the selected type of event is a space-related condition associated with a particular storage resource controlled by the storage controller. The computer-implemented method registers the host system with the storage controller. In response to detecting an event of the selected type on the storage controller, the computer-implemented method transmits a notification from the storage controller to the host system to provide notice of the event. A corresponding system and computer program product are also disclosed.

Abstract: A resin including up to 99.99 weight percent (wt. %) of a first polyolefin grafted with a functional group selected from an ethylenically unsaturated carboxylic acid, a carboxylic acid anhydride, an ester functional group or a combination thereof; and 0.01 to 3.0 wt. % of a tin oxide-based catalyst, where the resin includes 0.2 wt. % to 1.5 wt. % of the functional group from the first polyolefin, the wt. % based on a total weight of the resin. The first polyolefin can be selected from a polyethylene, a polypropylene, an ethylene/alpha-olefin copolymer, a propylene/alpha-olefin copolymer and combinations thereof. The tin oxide-based catalyst can be selected from dibutyltin oxide, dioctyltin oxide and combinations thereof. The resin can be used in a multilayer structure, where a Layer A comprises the resin and a Layer B comprises a polyester, where a first major surface of Layer A is in adhering contact with the second major surface of Layer B.

Abstract: An imaging system for use in a patient is provided. The system includes an imaging probe, a rotation assembly, and a retraction assembly. The imaging probe collects image data from a patient site and includes an elongate shaft with a proximal end and a distal portion, with a lumen extending therebetween. A rotatable optical core is positioned within the elongate shaft lumen and an optical assembly is positioned in the elongate shaft distal portion. The optical assembly directs light to tissue at the patient site and collects reflected light from the tissue. The rotation assembly connects to the imaging probe and rotates the optical assembly. The retraction assembly connects to the imaging probe and retracts the optical assembly and the elongate shaft in unison.

Abstract: A system for three-dimensional printing is disclosed. The system comprises: a rotary tray configured to rotate about a vertical axis; a printing head, each having a plurality of separated nozzles; and a controller configured for controlling the inkjet printing head to dispense, during the rotation, droplets of building material in layers, such as to print a three-dimensional object on the tray.

Abstract: Techniques are disclosed for unlocking in-game content for a video game application. In one embodiment, the video game application may be operated by a user that is concurrently viewing media content. The video game application captures an audio signal from the concurrently-playing media content, performs content recognition on the captured audio signal, and determines whether to unlock one or more portions of in-game content based on the identified media content.

Abstract: An osteotomy procedure may be performed to correct a misalignment of a bone, such as a bunion deformity. In some examples, the osteotomy procedure involves making a spherical-shaped cut transecting a first metatarsal, thereby forming a first metatarsal portion having a spherical-shaped projection and a second metatarsal portion having a spherical-shaped recess. The method further involves moving the second metatarsal portion in at least two planes relative to the first metatarsal portion, thereby adjusting an anatomical alignment of the second metatarsal portion.

Abstract: Surgical instruments for interfacing with implants can include an inserter configured to dock to a unilateral portion of an implant. The inserter can include a control shaft that is configured to lock or unlock the inserter coupling with the implant. Actuation of the control shaft can occur by way of a knob that can control movement of the control shaft. The inserter can facilitate positioning of the implant relative to a surgical site and allow for application of counter-torque when imparting torque for tightening a set screw, etc. Additional instruments can also be used to manipulate the implant. For example, auxiliary instruments can be coupled to the inserter, such as a reducer instrument, to facilitate rod reduction, etc. Alternatively or in addition, a holder instrument can be used that has a threaded distal engagement feature for coupling to the implant to facilitate positioning thereof.

Abstract: An equipment mounting system for mounting equipment to a support structure is described. An equipment mounting system including: (i) a mounting plate having defined therein a plate aperture of a particular shape; (ii) a bolt having a shaft portion including a threaded portion and a non-threaded portion that is of a complementary shape that complements the particular shape of the plate aperture; and (iii) a washer having defined therein a scored aperture that includes multiple radially extending scorings. In an assembled configuration of the mounting plate, the bolt and the washer, the plate aperture of the particular shape aligns with the scoring aperture such that both of the plate aperture and the scoring aperture receive the non-threaded portion of the complementary shape, and the particular shape of the mounting plate engages with the complementary shape of the bolt to prevent rotational displacement of the bolt around the mounting plate.

Abstract: The present disclosure relates to a showerhead that outputs a pulsating or massaging spray. The showerhead may include an engine including a flow directing housing, a turbine, and a shutter to create the pulsating or intermittent spray. The flow directing housing may have a plurality of flow directing apertures defined around its perimeter, allowing for water to tangentially flow into the engine, rotating the turbine. As the turbine rotates, the shutter moves back and forth creating the pulsating spray.

Abstract: Implants, instruments, and methods for performing surgical procedures on the spine, including one or more of creating an operative corridor to the spine, delivering implants to the spine, fusing one or more segments of the spine, and fixing one or more segments of the spine.

Abstract: A mill head for replaceable attachment to a base so as to collectively form a bone mill. The mill head includes shell with: a first opening in which bone stock is introduced into the head; and a second opening through which the bone chips are discharged. A cutting device is mounted in the shell to both rotate and move laterally. Attached to the cutting device are coupling features for engaging a drive spindle able to rotate the cutting device. Also attached to the housing is an alignment feature. The alignment feature engages a complementary alignment feature associated with the drive spindle so as a result of the engagement of the alignment features, the cutting device moves within the shell so that the cutting device coupling features are positioned to engage the drive spindle.

Abstract: A system for three-dimensional printing is disclosed. The system comprises: a rotary tray configured to rotate about a vertical axis; a printing head, each having a plurality of separated nozzles; and a controller configured for controlling the inkjet printing head to dispense, during the rotation, droplets of building material in layers, such as to print a three-dimensional object on the tray.

Abstract: A manifold for collecting a tissue sample with a medical waste collection assembly. A base portion of a housing is removably engaged with a manifold receiver to provide a suction path from an inlet fitting receiving a suction line. A tray may be removably positioned within an accessory sleeve. Locating features facilitate defining a gap between a base portion of the tray and a lower barrier of the accessory sleeve. The tray may include a control surface to move the manifold between a sealing configuration, and a bleed configuration in which a second suction path is provided through the gap and below the tray. A backflow prevention valve may be disposed within the suction path between the tray and a filter element. Methods for collecting the tissue sample are also disclosed.

Abstract: A collapsible detection antenna to detect electromagnetic tags of surgical articles in an operating room includes an antenna assembly configured to detect the electromagnetic tags. The antenna assembly is configured to move between a deployed configuration and a collapsed configuration. In the deployed configuration, the antenna assembly forms an antenna loop configured to detect the electromagnetic tags. The antenna assembly has a greater detection range in the deployed configuration than in the collapsed configuration. The deployed configuration corresponds to a tuned shape of the antenna assembly sufficient to detect the electromagnetic tags in the deployed configuration.

Abstract: An apparatus to separate water droplets from an air stream. The apparatus includes an elongated tube, a reservoir, and a helix structure. The elongated tube has a first end, a second end, a longitudinal axis, an inner surface, an inlet opening at the first end of the elongated tube, the inlet opening arranged to accept the air stream tangentially relative to the longitudinal axis, and an outlet opening at the second end of the elongated tube. The reservoir is positioned at a second end of the elongated tube. The helix structure is positioned within the elongated tube and includes an upper surface, a lower surface arranged opposite the upper surface, an outer edge, and a variable pitch along a length of the elongated tube, the variable pitch providing a variable interior angle between an inner wall of the elongated tube and the upper surface of the helix structure.

Abstract: A environmental control chamber device comprising a vacuum chamber, a controller, and at least one door is described. In an embodiment, the vacuum chamber is defined at an upper face, four or more lateral faces, and a lower face. The at least one door is connected to a respective one of the four or more lateral faces. The four or more lateral faces comprise at least one opening, and the at least one door is configured to seal the at least one opening. The controller is configured to control a pressure and a temperature within the vacuum chamber. The pressure may be a vacuum pressure, and the temperature may be a cryogenic temperature. Each door comprises a peripherally-lined seal configured to maintain a pressure within the vacuum chamber, and one or more radiation shields configured to maintain the temperature within the vacuum chamber.

Abstract: An apparatus and related methods to separate liquid from a liquid/gas mixture, particularly in a low gravity environment. The apparatus includes a chamber having a capillary channel around a perimeter of the chamber, a liquid/gas inlet to the chamber, a liquid outlet from the chamber, the liquid outlet being positioned at the perimeter of the chamber to remove liquid from the capillary channel, and a gas outlet from the chamber. The gas outlet is positioned in the chamber, away from the capillary channel, to remove gas from the chamber. The chamber is structured to be readily fabricated using traditional machining techniques or additive manufacturing techniques. The chamber may be fabricated from various materials, including, for example, polymers, metals, composites, and ceramics. The chamber may function as a heat exchanger so that the apparatus can remove condensable vapors from the gas in the mixture in addition to what is already liquid.

Abstract: A manifold for a medical/surgical waste collection system. An outlet opening and a fitting are in fluid communication with a manifold volume within a housing. The fitting receives a suction line. A filter element with porous features is disposed within the housing such that a fluid communication path is established across the filter element. The porous features trap material entrained within the fluid. A material collection volume is at least partially distal to and below a bottom of the filter element. As the fluid and the material is drawn through the fluid communication path, the material collects within the material collection volume. A flow diverter may be positioned within the housing for directing the material towards the material collection volume. The material collection volume may be at least partially defined by a tissue trap removably coupled to the housing.