Patents by Inventor Michael A. R. Freeman
Michael A. R. Freeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10254285Abstract: The invention provides methods for isolating large oncosomes and determining cancer metastasis based on the presence of large oncosomes and contents of the large oncosomes in a subject in need thereof. Also provided herein are methods for treating cancer metastasis by specifically targeting contents of the large oncosomes.Type: GrantFiled: October 14, 2015Date of Patent: April 9, 2019Assignee: Cedars-Sinai Medical CenterInventors: Dolores Di Vizio, Michael R. Freeman, Matteo Morello, Valentina R. Minciacchi
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Publication number: 20160061842Abstract: The invention provides methods for isolating large oncosomes and determining cancer metastasis based on the presence of large oncosomes and contents of the large oncosomes in a subject in need thereof. Also provided herein are methods for treating cancer metastasis by specifically targeting contents of the large oncosomes.Type: ApplicationFiled: October 14, 2015Publication date: March 3, 2016Applicant: Cedars-Sinai Medical CenterInventors: Dolores Di Vizio, Michael R. Freeman, Matteo Morello, Valentina R. Minciacchi
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Publication number: 20150037814Abstract: Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions.Type: ApplicationFiled: March 6, 2014Publication date: February 5, 2015Applicant: Children's Medical Center CorporationInventors: Marsha A. Moses, Michael R. Freeman, Dmitri Wiederschain
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Publication number: 20140178893Abstract: Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions.Type: ApplicationFiled: July 16, 2013Publication date: June 26, 2014Inventors: Marsha A. Moses, Michael R. Freeman, Dmitri Wiederschain
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Publication number: 20140056807Abstract: The invention provides methods for isolating large oncosomes and determining cancer metastasis based on the presence of large oncosomes in a subject in need thereof.Type: ApplicationFiled: August 23, 2013Publication date: February 27, 2014Applicant: Cedars-Sinai Medical CenterInventors: Dolores Di Vizio, Michael R. Freeman, Matteo Morello
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Publication number: 20090208448Abstract: Cholesterol-uptake-blocking drugs inhibit angiogenesis and are useful to inhibit diseases perpetuated by angiogenesis. Cholesterol reduction with the use of the drugs increases the intratumoral level of thrombospondin-1, an angiogenesis inhibitor. Ezetimibe (Zetia®), a specific cholesterol-uptake blocking drug, also retards the growth of human tumors, most preferably in combination with low-cholesterol diet. The pharmacologic reduction in serum cholesterol retards prostate cancer growth by inhibiting tumor angiogenesis to combat the growth of prostatic tumors which are directly accelerated by hypercholesterolemia.Type: ApplicationFiled: February 12, 2009Publication date: August 20, 2009Inventors: Keith R. Solomon, Kristine Pelton, Carl P. Schaffner, Michael R. Freeman
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Patent number: 7449453Abstract: A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe (SCH 58235) and/or its phenolic glucuronide, or at least one ezetimibe analog, e.g., SCH 48461 and SCH 58053, to a patient wherein the patient is either at risk of developing a cholesterol-associated tumor or already exhibits a cholesterol-associated tumor. Formulations of ezetimibe are also provided for the prevention or treatment of a cholesterol-associated tumor further comprising at least one other anticancer agent.Type: GrantFiled: July 13, 2006Date of Patent: November 11, 2008Assignees: Karykion Inc., Children's Medical Center CorporationInventors: Carl P. Schaffner, Keith R. Solomon, Michael R. Freeman
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Patent number: 6933292Abstract: A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe (SCH 58235) and/or its phenolic glucuronide, or at least one ezetimibe analog, e.g., SCH 48461 and SCH 58053, to a patient wherein the patient is either at risk of developing a cholesterol-associated tumor or already exhibits a cholesterol-associated tumor. Formulations of ezetimibe are also provided for the prevention or treatment of a cholesterol-associated tumor further comprising at least one other anticancer agent.Type: GrantFiled: July 30, 2003Date of Patent: August 23, 2005Assignee: Children's Medical Center CorporationInventors: Carl P. Schaffner, Keith R. Solomon, Michael R. Freeman
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Patent number: 6811995Abstract: The present invention relates to non-invasive methods for facilitating the diagnosis of a subject as having cancer. The described methods involve detecting the presence of a matrix metalloproteinase in urine samples obtained from a patient and correlating the presence or absence of the matrix metalloproteinase with the presence or absence of cancer. Methods for monitoring the prognosis of a patient by detection of matrix metalloproteinase are also provided.Type: GrantFiled: December 22, 1999Date of Patent: November 2, 2004Assignee: Children's Medical Center CorporationInventors: Marsha A. Moses, Michael R. Freeman, Dmitri Wiederschain
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Publication number: 20040116358Abstract: A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption inhibitor, preferably ezetimibe (SCH 58235) and/or its phenolic glucuronide, or at least one ezetimibe analog, e.g., SCH 48461 and SCH 58053, to a patient wherein the patient is either at risk of developing a cholesterol-associated tumor or already exhibits a cholesterol-associated tumor. Formulations of ezetimibe are also provided for the prevention or treatment of a cholesterol-associated tumor further comprising at least one other anticancer agent.Type: ApplicationFiled: July 30, 2003Publication date: June 17, 2004Inventors: Carl P. Schaffner, Keith R. Solomon, Michael R. Freeman
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Publication number: 20030215900Abstract: Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions.Type: ApplicationFiled: April 16, 2003Publication date: November 20, 2003Inventors: Marsha A. Moses, Michael R. Freeman, Dmitri Wiederschain
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Patent number: 6037138Abstract: Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions.Type: GrantFiled: April 25, 1997Date of Patent: March 14, 2000Assignee: The Children's Medical Center Corp.Inventors: Marsha A. Moses, Michael R. Freeman, Dmitri Wiederschain
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Patent number: 5567612Abstract: Methods and artificial matrices for the growth and implantation of urological structures and surfaces are disclosed in which urothelial cells are grown in culture on biodegradable, biocompatible, fibrous matrices formed of polymers, such as polyglycolic acid, polylactic acid, or other polymers which degrade over time. The cells can be cultured in vitro until an adequate cell volume and density has developed for the cells to survive and proliferate in vivo. Alternatively, when adequate cell numbers for implantation are available, the cells can be attached to the matrix and implanted directly, without proliferation in vitro. The implants approximate the desired urological structure to be replaced or repaired, such as the kidney, urether, bladder, urethra, and the like. Implantation is followed by remodeling through cell growth and proliferation in vivo.Type: GrantFiled: July 27, 1993Date of Patent: October 22, 1996Assignees: Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Joseph P. Vacanti, Michael R. Freeman
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Patent number: 5219362Abstract: A knee prosthesis comprises (i) a femoral component having a medial condyle and a lateral condyle and (ii) a tibial component. The rolling surface of the medial condyle is part-spherical and the tibial component has a complementary part-spherical depression in its upper surface to receive the medial condyle. The bearing surface of the lateral condyle includes a posterior part which has a curvature in a substantially sagittal plane about a first point on a transverse axis that passes through the center of curvature of the rolling surface of the medial condyle and an anterior part which has a curvature in the same plane about a point that lies on a second transverse axis parallel to, and anterior to, the first transverse axis. The tibial component has an arcuate groove to receive the lateral condyle and to permit, in flexion of the knee after implantation, limited anterior/posterior movement of the lateral side of the tibia relative to the femur.Type: GrantFiled: February 6, 1992Date of Patent: June 15, 1993Assignee: Finsbury (Instruments) LimitedInventors: Michael A. Tuke, Michael A. R. Freeman
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Patent number: 4738256Abstract: A surgical tool, for use in hip replacement operations comprises a substantially linear stem which in use seats within a preformed femur cavity. A fixed arm extends medially from an upper portion of the stem and terminates in support for a rotatable cutter. One end of the cutter is received in a seating on the stem below the fixed arm. Ancilliary equipment includes a depth locating tool, so correctly positioning the hip implant in relation to the retained femur neck.Type: GrantFiled: June 26, 1986Date of Patent: April 19, 1988Assignee: Finsbury (Instruments) LimitedInventors: Michael A. R. Freeman, Michael A. Tuke
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Patent number: 4670015Abstract: A hip implant has a stem portion with a substantially linear axis and a circular cross-section at least in the region of the bottom end thereof. A wedge-shaped portion extends medially from the stem at or near the top end of the stem. The wedge-shaped portion is surmounted by a ball.Type: GrantFiled: April 8, 1985Date of Patent: June 2, 1987Assignee: Finsbury (Instruments) LimitedInventor: Michael A. R. Freeman